Burden of upper gastrointestinal cancers in the east of Golestan province (Golestan cohort study)
Abstract Background Cancers, especially Upper Gastrointestinal Cancers (UGCs), pose a substantial burden on society, particularly in developing nations. Golestan province, Iran, is known for its high UGC rates globally. Aims This study delves into the disease burden of UGCs in the eastern part of Go...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-03-01
|
| Series: | Cancer Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cnr2.2001 |
| _version_ | 1797236891166179328 |
|---|---|
| author | Mohammad‐Ali Jahani Raziyeh Esmaeili Mahdi Abbasi Hossein‐Ali Nikbakht Habibollah Azarbakhsh Gholamreza Roshandel Sahar Delavari Layla Shojaie Ghahraman Mahmoudi |
| author_facet | Mohammad‐Ali Jahani Raziyeh Esmaeili Mahdi Abbasi Hossein‐Ali Nikbakht Habibollah Azarbakhsh Gholamreza Roshandel Sahar Delavari Layla Shojaie Ghahraman Mahmoudi |
| author_sort | Mohammad‐Ali Jahani |
| collection | DOAJ |
| description | Abstract Background Cancers, especially Upper Gastrointestinal Cancers (UGCs), pose a substantial burden on society, particularly in developing nations. Golestan province, Iran, is known for its high UGC rates globally. Aims This study delves into the disease burden of UGCs in the eastern part of Golestan province. Methods and Results This study was conducted using the results of the Golestan cohort study. 2711 patients participating in this cohort, who visited Atrak Clinic during 2001–2020, participated in this study. After excluding patients with incomplete records, 2481 patients were included in the study. To compute the metrics of years of life lost (YLL), years of life lived with disability (YLD), and disability‐adjusted life years (DALY), we utilized the World Health Organization's standard life table, stratified by age and gender. The majority of UGC patients in our study were married (81.8%), had limited formal education (82.6%), and were predominantly male (61.1%). A substantial proportion resided in suburban areas (85.8%), and over half of the patients (52%) reported a history of drug addiction. The mean age at diagnosis for men was 65.76 years with a standard deviation of 11.34, while for women, it was 64.38 years with a standard deviation of 11.66. Regarding disease impact, YLL, YLD, and DALY for men were 21 240, 1956, and 23 196 (307.8 per 100 000), respectively. For women, these figures were 15 609 for YLL, 1367 for YLD, and 16 976 (223.1 per 100 000) for DALY. Conclusion After the increasing trend of the burden of UGCs in Golestan province in the early years of the study, this rate has been decreasing in recent years. Effective strategies necessitate collaborative efforts across various sectors to alleviate this burden, focusing on preventive measures, timely diagnosis, and well‐coordinated therapeutic interventions. |
| first_indexed | 2024-04-24T17:11:03Z |
| format | Article |
| id | doaj.art-d7fd2f9747e8498984345c41e51d0f29 |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-04-24T17:11:03Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-d7fd2f9747e8498984345c41e51d0f292024-03-28T12:30:35ZengWileyCancer Reports2573-83482024-03-0173n/an/a10.1002/cnr2.2001Burden of upper gastrointestinal cancers in the east of Golestan province (Golestan cohort study)Mohammad‐Ali Jahani0Raziyeh Esmaeili1Mahdi Abbasi2Hossein‐Ali Nikbakht3Habibollah Azarbakhsh4Gholamreza Roshandel5Sahar Delavari6Layla Shojaie7Ghahraman Mahmoudi8Social Determinants of Health Research Center Health Research Institute, Babol University of Medical Sciences Babol IranHealth Services Management Golestan University of Medical Sciences Gorgan IranDepartment of Health Economics and Management School of Public Health, Tehran University of Medical Sciences Tehran IranSocial Determinants of Health Research Center Health Research Institute, Babol University of Medical Sciences Babol IranStudent Research Committee Shiraz University of Medical Sciences Shiraz IranGolestan Research Center of Gastroenterology and Hepatology Golestan University of Medical Sciences Gorgan IranInstitute for the Developing Mind, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California Los Angeles California USADivision of GI/Liver, Department of Medicine Keck school of Medicine, University of Southern California Los Angeles California USAHospital administration Research Center, Sari Branch, Islamic Azad University Sari IranAbstract Background Cancers, especially Upper Gastrointestinal Cancers (UGCs), pose a substantial burden on society, particularly in developing nations. Golestan province, Iran, is known for its high UGC rates globally. Aims This study delves into the disease burden of UGCs in the eastern part of Golestan province. Methods and Results This study was conducted using the results of the Golestan cohort study. 2711 patients participating in this cohort, who visited Atrak Clinic during 2001–2020, participated in this study. After excluding patients with incomplete records, 2481 patients were included in the study. To compute the metrics of years of life lost (YLL), years of life lived with disability (YLD), and disability‐adjusted life years (DALY), we utilized the World Health Organization's standard life table, stratified by age and gender. The majority of UGC patients in our study were married (81.8%), had limited formal education (82.6%), and were predominantly male (61.1%). A substantial proportion resided in suburban areas (85.8%), and over half of the patients (52%) reported a history of drug addiction. The mean age at diagnosis for men was 65.76 years with a standard deviation of 11.34, while for women, it was 64.38 years with a standard deviation of 11.66. Regarding disease impact, YLL, YLD, and DALY for men were 21 240, 1956, and 23 196 (307.8 per 100 000), respectively. For women, these figures were 15 609 for YLL, 1367 for YLD, and 16 976 (223.1 per 100 000) for DALY. Conclusion After the increasing trend of the burden of UGCs in Golestan province in the early years of the study, this rate has been decreasing in recent years. Effective strategies necessitate collaborative efforts across various sectors to alleviate this burden, focusing on preventive measures, timely diagnosis, and well‐coordinated therapeutic interventions.https://doi.org/10.1002/cnr2.2001burden of diseasedisability‐adjusted life yearsIranupper gastrointestinal cancer |
| spellingShingle | Mohammad‐Ali Jahani Raziyeh Esmaeili Mahdi Abbasi Hossein‐Ali Nikbakht Habibollah Azarbakhsh Gholamreza Roshandel Sahar Delavari Layla Shojaie Ghahraman Mahmoudi Burden of upper gastrointestinal cancers in the east of Golestan province (Golestan cohort study) Cancer Reports burden of disease disability‐adjusted life years Iran upper gastrointestinal cancer |
| title | Burden of upper gastrointestinal cancers in the east of Golestan province (Golestan cohort study) |
| title_full | Burden of upper gastrointestinal cancers in the east of Golestan province (Golestan cohort study) |
| title_fullStr | Burden of upper gastrointestinal cancers in the east of Golestan province (Golestan cohort study) |
| title_full_unstemmed | Burden of upper gastrointestinal cancers in the east of Golestan province (Golestan cohort study) |
| title_short | Burden of upper gastrointestinal cancers in the east of Golestan province (Golestan cohort study) |
| title_sort | burden of upper gastrointestinal cancers in the east of golestan province golestan cohort study |
| topic | burden of disease disability‐adjusted life years Iran upper gastrointestinal cancer |
| url | https://doi.org/10.1002/cnr2.2001 |
| work_keys_str_mv | AT mohammadalijahani burdenofuppergastrointestinalcancersintheeastofgolestanprovincegolestancohortstudy AT raziyehesmaeili burdenofuppergastrointestinalcancersintheeastofgolestanprovincegolestancohortstudy AT mahdiabbasi burdenofuppergastrointestinalcancersintheeastofgolestanprovincegolestancohortstudy AT hosseinalinikbakht burdenofuppergastrointestinalcancersintheeastofgolestanprovincegolestancohortstudy AT habibollahazarbakhsh burdenofuppergastrointestinalcancersintheeastofgolestanprovincegolestancohortstudy AT gholamrezaroshandel burdenofuppergastrointestinalcancersintheeastofgolestanprovincegolestancohortstudy AT sahardelavari burdenofuppergastrointestinalcancersintheeastofgolestanprovincegolestancohortstudy AT laylashojaie burdenofuppergastrointestinalcancersintheeastofgolestanprovincegolestancohortstudy AT ghahramanmahmoudi burdenofuppergastrointestinalcancersintheeastofgolestanprovincegolestancohortstudy |