Novel Thiazole Derivatives Containing Imidazole and Furan Scaffold: Design, Synthesis, Molecular Docking, Antibacterial, and Antioxidant Evaluation

Novel Thiazole Derivatives Containing Imidazole and Furan Scaffold: Design, Synthesis, Molecular Docking, Antibacterial, and Antioxidant Evaluation

Carbothioamides <b>3a</b>,<b>b</b> were generated in high yield by reacting furan imidazolyl ketone <b>1</b> with <i>N</i>-arylthiosemicarbazide in EtOH with a catalytic amount of conc. HCl. The reaction of carbothioamides <b>3a</b>,<b&g...

Full description

Bibliographic Details
Main Author:	Fatimah Agili
Format:	Article
Language:	English
Published:	MDPI AG 2024-03-01
Series:	Molecules
Subjects:	thiazol imidazole furan molecular docking DNA gyrase B antibacterial
Online Access:	https://www.mdpi.com/1420-3049/29/7/1491

Similar Items

Evaluation of anti-bacterial effects of some novel thiazole and imidazole derivatives against some pathogenic bacteria
by: Behzad Ghasemi, et al.
Published: (2015-12-01)

Study of Antibacterial Effect of Novel Thiazole, Imidazole and Tetrahydropyridine Derivatives against Escherichia coli
by: Behzad Ghasemi, et al.
Published: (2016-02-01)

Study of Antibacterial Effect of Novel Thiazole, Imidazole and Tetrahydropyridine Derivatives against Escherichia coli
by: Behzad Ghasemi, et al.
Published: (2016-01-01)

Study of Antibacterial Effect of Novel Thiazole, Imidazole and Tetrahydropyridine Derivatives against Escherichia coli
by: Behzad Ghasemi, et al.
Published: (2015-12-01)

5-Chloro-6-oxo-6<i>H</i>-xantheno[4,3-<i>d</i>]thiazole-2-carbonitrile
by: Konstantinos Paraskevas, et al.
Published: (2022-11-01)

Density Functional Theory Applied to Excited State Intramolecular Proton Transfer in Imidazole-, Oxazole-, and Thiazole-Based Systems
by: Fabricio de Carvalho, et al.
Published: (2018-05-01)

Synthesis and Antimicrobial Activity of New Heteroaryl(aryl) Thiazole Derivatives Molecular Docking Studies
by: Victor Kartsev, et al.
Published: (2022-09-01)

Synthesis, antibacterial and antioxidant activities of Thiazole-based Schiff base derivatives: a combined experimental and computational study
by: Fitsum Lemilemu, et al.
Published: (2021-12-01)

Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides
by: Volodymyr Ya Horishny, et al.
Published: (2020-08-01)

The Computational Calculation and Molecular Docking of Aeroplysinin-1 As Antibacterial
by: Mirella Fonda Maahury, et al.
Published: (2021-09-01)

New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation
by: Cristina Nastasă, et al.
Published: (2015-09-01)

The anti-HIV potential of imidazole, oxazole and thiazole hybrids: A mini-review
by: Cui Deng, et al.
Published: (2022-11-01)

Synthesis, characterization and molecular docking studies of bioactive 1,3-Thiazoles as promising antibacterial and antioxidant agents
by: Abdul Ghafoor, et al.
Published: (2024-01-01)

Synthesis, antibacterial, antifungal, antioxidant, cytotoxicity and molecular docking studies of thiazole derivatives
by: Keshav B. Gangurde, et al.
Published: (2024-01-01)

Docking studies on novel analogs of quinolones against DNA gyrase of Escherichia coli
by: Cristian Davila, et al.
Published: (2018-09-01)

Synthesis and Antimicrobial Evaluation of Certain Novel Thiazoles
by: Lakshmana Rao Krishna Rao Ravindranath, et al.
Published: (2013-02-01)

Synthesis, Molecular Docking Study, and Cytotoxic Activity against MCF Cells of New Thiazole–Thiophene Scaffolds
by: Sobhi M. Gomha, et al.
Published: (2022-07-01)

(<em>E</em>)-<em>N</em>′-(4-Fluorobenzylidene)-5-methyl-2-(pyridin-3-yl)thiazole-4-carbohydrazide
by: Vinuta Kamat, et al.
Published: (2019-05-01)

Antibacterial Evaluation, In Silico Characters and Molecular Docking of Schiff Bases Derived from 5-aminopyrazoles
by: Ashraf S. Hassan, et al.
Published: (2019-08-01)

Synthesis, molecular docking, in silico study, and evaluation of bis-thiazole-based curcumin derivatives as potential antimicrobial agents
by: Sobhi M. Gomha, et al.
Published: (2024-01-01)

Synthesis, antimicrobial and antioxidant activity of triazole, pyrazole containing thiazole derivatives and molecular docking studies on COVID-19
by: Raghavender Matta, et al.
Published: (2023-06-01)

In Silico Molecular Docking, Synthesis and Preliminary Evaluation of Antibacterial Activity of Levofloxacin Carboxamides with Certain Amino Acids
by: Sarah Abdul-Razzaq makki, et al.
Published: (2023-02-01)

Synthesis and preliminary pharmacological profile of some new 3,5-dihydro-4H-imidazol-4-one and α,β-dehydroamino acid derivatives
by: Nabard Ghafur Ahmed ,Aras N. Hamad
Published: (2023-02-01)

Spectral, DFT studies, molecular docking and antibacterial activity of Schiff base derived from furan-2-carbaldehyde and their metal (II) complexes
by: Manjuraj T, et al.
Published: (2020-06-01)

Antibacterial Evaluation of New Thiazole, Imidazolidine and Tetrahydropyrimidine Derivatives against Pathogenic Gram-Negative Bacteria
by: Hamid Beyzaei, et al.
Published: (2015-11-01)

Synthesis and Biological Evaluation of New Pyridothienopyrimidine Derivatives as Antibacterial Agents and <i>Escherichia coli</i> Topoisomerase II Inhibitors
by: Eman M. Mohi El-Deen, et al.
Published: (2020-10-01)

Experimental and Molecular Docking Studies of Cyclic Diphenyl Phosphonates as DNA Gyrase Inhibitors for Fluoroquinolone-Resistant Pathogens
by: Neveen M. Saleh, et al.
Published: (2022-01-01)

Synthesis of tetrazole hybridized with thiazole, thiophene or thiadiazole derivatives, molecular modelling and antimicrobial activity
by: Matokah M. Abualnaja, et al.
Published: (2024-03-01)

Design, synthesis, anticancer activity and docking studies of novel quinazoline-based thiazole derivatives as EGFR kinase inhibitors
by: M.S. Raghu, et al.
Published: (2023-09-01)

Syntheses, Antibacterial and Antifungal Activities of Substituted-Thiazolo-1,3,4-Thiadiazoles, 1,3,4-Oxadiazoles and 1,2,4-Thiazoles
by: Abbas Shafiee, et al.
Published: (1998-06-01)

Identification of novel antifungal agents: antimicrobial evaluation, SAR, ADME–Tox and molecular docking studies of a series of imidazole derivatives
by: Btissam Bouchal, et al.
Published: (2019-08-01)

From the DNA Gyrase Inhibitor Cyclothialidine to a New Class of Antibacterial Agents
by: Erwin Goetschi, et al.
Published: (2003-04-01)

Design, synthesis, molecular docking studies and biological evaluation of thiazole carboxamide derivatives as COX inhibitors
by: Mohammed Hawash, et al.
Published: (2023-03-01)

Novel Structural Hybrids of Pyrrole and Thiazole Moieties: Synthesis and Evaluation of Antibacterial and Antifungal Activities
by: Mohamed Salem, et al.
Published: (2021-12-01)

Thiazole ring- the antimicrobial, anti-inflammatory, and anticancer active scaffold
by: Seyedmohammad Hosseininezhad, et al.
Published: (2023-11-01)

4-(4-Bromophenyl)-thiazol-2-amine derivatives: synthesis, biological activity and molecular docking study with ADME profile
by: Deepika Sharma, et al.
Published: (2019-04-01)

s-Triazine Derivatives Functionalized with Alkylating 2-Chloroethylamine Fragments as Promising Antimicrobial Agents: Inhibition of Bacterial DNA Gyrases, Molecular Docking Studies, and Antibacterial and Antifungal Activity
by: Dawid Maliszewski, et al.
Published: (2023-09-01)

Design, synthesis and docking studies of new hydrazinyl-thiazole derivatives as anticancer and antimicrobial agents
by: Abeer M. El-Naggar, et al.
Published: (2022-07-01)

Synthesis, molecular modeling and bioactivity of new bis-thiazole, thiazole-pyrazole, and thiazole-pyridine analogues
by: Abrar Bayazeed, et al.
Published: (2023-11-01)

Studies on the Synthesis and Reactivity of Novel Benzofuran-2-yl-[3-Methyl-3-Phenylcyclobutyl] Methanones and their Antimicrobial Activity
by: Cavit Kazaz, et al.
Published: (2005-08-01)