The Effect of Different Head Movement Paradigms on Vestibulo-Ocular Reflex Gain and Saccadic Eye Responses in the Suppression Head Impulse Test in Healthy Adult Volunteers
Objective: This study aimed to identify differences in vestibulo-ocular reflex gain (VOR gain) and saccadic response in the suppression head impulse paradigm (SHIMP) between predictable and less predictable head movements, in a group of healthy subjects. It was hypothesized that higher prediction co...
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.729081/full |
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| author | Dmitrii Starkov Dmitrii Starkov Bernd Vermorken T. S. Van Dooren Lisa Van Stiphout Miranda Janssen Miranda Janssen Maksim Pleshkov Maksim Pleshkov Nils Guinand Nils Guinand Angelica Pérez Fornos Vincent Van Rompaey Vincent Van Rompaey Herman Kingma Herman Kingma Raymond Van de Berg Raymond Van de Berg |
| author_facet | Dmitrii Starkov Dmitrii Starkov Bernd Vermorken T. S. Van Dooren Lisa Van Stiphout Miranda Janssen Miranda Janssen Maksim Pleshkov Maksim Pleshkov Nils Guinand Nils Guinand Angelica Pérez Fornos Vincent Van Rompaey Vincent Van Rompaey Herman Kingma Herman Kingma Raymond Van de Berg Raymond Van de Berg |
| author_sort | Dmitrii Starkov |
| collection | DOAJ |
| description | Objective: This study aimed to identify differences in vestibulo-ocular reflex gain (VOR gain) and saccadic response in the suppression head impulse paradigm (SHIMP) between predictable and less predictable head movements, in a group of healthy subjects. It was hypothesized that higher prediction could lead to a lower VOR gain, a shorter saccadic latency, and higher grouping of saccades.Methods: Sixty-two healthy subjects were tested using the video head impulse test and SHIMPs in four conditions: active and passive head movements for both inward and outward directions. VOR gain, latency of the first saccade, and the level of saccade grouping (PR-score) were compared among conditions. Inward and active head movements were considered to be more predictable than outward and passive head movements.Results: After validation, results of 57 tested subjects were analyzed. Mean VOR gain was significantly lower for inward passive compared with outward passive head impulses (p < 0.001), and it was higher for active compared with passive head impulses (both inward and outward) (p ≤ 0.024). Mean latency of the first saccade was significantly shorter for inward active compared with inward passive (p ≤ 0.001) and for inward passive compared with outward passive head impulses (p = 0.012). Mean PR-score was only significantly higher in active outward than in active inward head impulses (p = 0.004).Conclusion: For SHIMP, a higher predictability in head movements lowered gain only in passive impulses and shortened latencies of compensatory saccades overall. For active impulses, gain calculation was affected by short-latency compensatory saccades, hindering reliable comparison with gains of passive impulses. Predictability did not substantially influence grouping of compensatory saccades. |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-22T00:40:07Z |
| publishDate | 2021-09-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-d7ff61a54bd04fc79cb1a8c267913d522022-12-21T18:44:42ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-09-011210.3389/fneur.2021.729081729081The Effect of Different Head Movement Paradigms on Vestibulo-Ocular Reflex Gain and Saccadic Eye Responses in the Suppression Head Impulse Test in Healthy Adult VolunteersDmitrii Starkov0Dmitrii Starkov1Bernd Vermorken2T. S. Van Dooren3Lisa Van Stiphout4Miranda Janssen5Miranda Janssen6Maksim Pleshkov7Maksim Pleshkov8Nils Guinand9Nils Guinand10Angelica Pérez Fornos11Vincent Van Rompaey12Vincent Van Rompaey13Herman Kingma14Herman Kingma15Raymond Van de Berg16Raymond Van de Berg17Division of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, Maastricht, NetherlandsFaculty of Physics, Tomsk State Research University, Tomsk, RussiaDivision of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, Maastricht, NetherlandsDivision of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, Maastricht, NetherlandsDivision of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, Maastricht, NetherlandsDivision of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, Maastricht, NetherlandsDepartment of Methodology and Statistics, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, NetherlandsDivision of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, Maastricht, NetherlandsFaculty of Physics, Tomsk State Research University, Tomsk, RussiaDivision of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, Maastricht, NetherlandsService of Otorhinolaryngology Head and Neck Surgery, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, SwitzerlandService of Otorhinolaryngology Head and Neck Surgery, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, SwitzerlandFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, BelgiumDivision of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, Maastricht, NetherlandsFaculty of Physics, Tomsk State Research University, Tomsk, RussiaDivision of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, Maastricht, NetherlandsFaculty of Physics, Tomsk State Research University, Tomsk, RussiaObjective: This study aimed to identify differences in vestibulo-ocular reflex gain (VOR gain) and saccadic response in the suppression head impulse paradigm (SHIMP) between predictable and less predictable head movements, in a group of healthy subjects. It was hypothesized that higher prediction could lead to a lower VOR gain, a shorter saccadic latency, and higher grouping of saccades.Methods: Sixty-two healthy subjects were tested using the video head impulse test and SHIMPs in four conditions: active and passive head movements for both inward and outward directions. VOR gain, latency of the first saccade, and the level of saccade grouping (PR-score) were compared among conditions. Inward and active head movements were considered to be more predictable than outward and passive head movements.Results: After validation, results of 57 tested subjects were analyzed. Mean VOR gain was significantly lower for inward passive compared with outward passive head impulses (p < 0.001), and it was higher for active compared with passive head impulses (both inward and outward) (p ≤ 0.024). Mean latency of the first saccade was significantly shorter for inward active compared with inward passive (p ≤ 0.001) and for inward passive compared with outward passive head impulses (p = 0.012). Mean PR-score was only significantly higher in active outward than in active inward head impulses (p = 0.004).Conclusion: For SHIMP, a higher predictability in head movements lowered gain only in passive impulses and shortened latencies of compensatory saccades overall. For active impulses, gain calculation was affected by short-latency compensatory saccades, hindering reliable comparison with gains of passive impulses. Predictability did not substantially influence grouping of compensatory saccades.https://www.frontiersin.org/articles/10.3389/fneur.2021.729081/fullvestibular ocular reflexvideo head impulse test (vHIT)suppression head impulse paradigmactive head impulsepassive head impulseinward head impulse |
| spellingShingle | Dmitrii Starkov Dmitrii Starkov Bernd Vermorken T. S. Van Dooren Lisa Van Stiphout Miranda Janssen Miranda Janssen Maksim Pleshkov Maksim Pleshkov Nils Guinand Nils Guinand Angelica Pérez Fornos Vincent Van Rompaey Vincent Van Rompaey Herman Kingma Herman Kingma Raymond Van de Berg Raymond Van de Berg The Effect of Different Head Movement Paradigms on Vestibulo-Ocular Reflex Gain and Saccadic Eye Responses in the Suppression Head Impulse Test in Healthy Adult Volunteers Frontiers in Neurology vestibular ocular reflex video head impulse test (vHIT) suppression head impulse paradigm active head impulse passive head impulse inward head impulse |
| title | The Effect of Different Head Movement Paradigms on Vestibulo-Ocular Reflex Gain and Saccadic Eye Responses in the Suppression Head Impulse Test in Healthy Adult Volunteers |
| title_full | The Effect of Different Head Movement Paradigms on Vestibulo-Ocular Reflex Gain and Saccadic Eye Responses in the Suppression Head Impulse Test in Healthy Adult Volunteers |
| title_fullStr | The Effect of Different Head Movement Paradigms on Vestibulo-Ocular Reflex Gain and Saccadic Eye Responses in the Suppression Head Impulse Test in Healthy Adult Volunteers |
| title_full_unstemmed | The Effect of Different Head Movement Paradigms on Vestibulo-Ocular Reflex Gain and Saccadic Eye Responses in the Suppression Head Impulse Test in Healthy Adult Volunteers |
| title_short | The Effect of Different Head Movement Paradigms on Vestibulo-Ocular Reflex Gain and Saccadic Eye Responses in the Suppression Head Impulse Test in Healthy Adult Volunteers |
| title_sort | effect of different head movement paradigms on vestibulo ocular reflex gain and saccadic eye responses in the suppression head impulse test in healthy adult volunteers |
| topic | vestibular ocular reflex video head impulse test (vHIT) suppression head impulse paradigm active head impulse passive head impulse inward head impulse |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.729081/full |
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