Selectively targeting haemagglutinin antigen to chicken CD83 receptor induces faster and stronger immunity against avian influenza

Selectively targeting haemagglutinin antigen to chicken CD83 receptor induces faster and stronger immunity against avian influenza

Abstract The immunogenicity and protective efficacy of vaccines can be enhanced by the selective delivery of antigens to the antigen-presenting cells (APCs). In this study, H9N2 avian influenza virus haemagglutinin (HA) antigen, was targeted by fusing it to single-chain fragment variable (scFv) anti...

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Bibliographic Details
Main Authors: Angita Shrestha, Jean-Remy Sadeyen, Deimante Lukosaityte, Pengxiang Chang, Adrian Smith, Marielle Van Hulten, Munir Iqbal
Format: Article
Language:English
Published: Nature Portfolio 2021-07-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-021-00350-3

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