RETRACTED ARTICLE: Artificial photoactive chlorophyll conjugated vanadium carbide nanostructure for synergistic photothermal/photodynamic therapy of cancer
Abstract Optically active nanostructures consisting of organic compounds and metallic support have shown great promise in phototherapy due to their increased light absorption capacity and high energy conversion. Herein, we conjugated chlorophyll (Chl) to vanadium carbide (V2C) nanosheets for combine...
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01331-x |
| _version_ | 1797376805034786816 |
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| author | Huiting Lu Shah Zada Songsong Tang Cheng Yaru Wei Wei Qiao Yuchun Qiqi Yang Jinya Du Pengcheng Fu Haifeng Dong Xueji Zhang |
| author_facet | Huiting Lu Shah Zada Songsong Tang Cheng Yaru Wei Wei Qiao Yuchun Qiqi Yang Jinya Du Pengcheng Fu Haifeng Dong Xueji Zhang |
| author_sort | Huiting Lu |
| collection | DOAJ |
| description | Abstract Optically active nanostructures consisting of organic compounds and metallic support have shown great promise in phototherapy due to their increased light absorption capacity and high energy conversion. Herein, we conjugated chlorophyll (Chl) to vanadium carbide (V2C) nanosheets for combined photodynamic/photothermal therapy (PDT/PTT), which reserves the advantages of each modality while minimizing the side effects to achieve an improved therapeutic effect. In this system, the Chl from Leptolyngbya JSC-1 extracts acted as an efficient light-harvest antenna in a wide NIR range and photosensitizers (PSs) for oxygen self-generation hypoxia-relief PDT. The available large surface of two-dimensional (2D) V2C showed high Chl loading efficiency, and the interaction between organic Chl and metallic V2C led to energy conversion efficiency high to 78%. Thus, the Chl/ V2C nanostructure showed advanced performance in vitro cell line killing and completely ablated tumors in vivo with 100% survival rate under a single NIR irradiation. Our results suggest that the artificial optical Chl/V2C nanostructure will benefit photocatalytic tumor eradication clinic application. Graphical Abstract |
| first_indexed | 2024-03-08T19:44:50Z |
| format | Article |
| id | doaj.art-d80007f0558d42a9b4b45fd200ed98fb |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-03-08T19:44:50Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-d80007f0558d42a9b4b45fd200ed98fb2023-12-24T12:28:26ZengBMCJournal of Nanobiotechnology1477-31552022-03-0120111310.1186/s12951-022-01331-xRETRACTED ARTICLE: Artificial photoactive chlorophyll conjugated vanadium carbide nanostructure for synergistic photothermal/photodynamic therapy of cancerHuiting Lu0Shah Zada1Songsong Tang2Cheng Yaru3Wei Wei4Qiao Yuchun5Qiqi Yang6Jinya Du7Pengcheng Fu8Haifeng Dong9Xueji Zhang10School of Chemistry and Biological Engineering, University of Science & Technology BeijingMarshall Laboratory of Biomedical Engineering, Research Center for Biosensor and Nanotheranostic, School of Biomedical Engineering, Shenzhen UniversityBeijing Key Laboratory for Bioengineering and Sensing Technology, Research Center for Bioengineering and Sensing Technology, School of Chemistry and Bioengineering, University of Science & Technology BeijingBeijing Key Laboratory for Bioengineering and Sensing Technology, Research Center for Bioengineering and Sensing Technology, School of Chemistry and Bioengineering, University of Science & Technology BeijingBeijing Key Laboratory for Bioengineering and Sensing Technology, Research Center for Bioengineering and Sensing Technology, School of Chemistry and Bioengineering, University of Science & Technology BeijingBeijing Key Laboratory for Bioengineering and Sensing Technology, Research Center for Bioengineering and Sensing Technology, School of Chemistry and Bioengineering, University of Science & Technology BeijingMarshall Laboratory of Biomedical Engineering, Research Center for Biosensor and Nanotheranostic, School of Biomedical Engineering, Shenzhen UniversityBeijing Key Laboratory for Bioengineering and Sensing Technology, Research Center for Bioengineering and Sensing Technology, School of Chemistry and Bioengineering, University of Science & Technology BeijingState Key Laboratory of Marine Resource Utilization in South China Sea Hainan UniversityMarshall Laboratory of Biomedical Engineering, Research Center for Biosensor and Nanotheranostic, School of Biomedical Engineering, Shenzhen UniversityMarshall Laboratory of Biomedical Engineering, Research Center for Biosensor and Nanotheranostic, School of Biomedical Engineering, Shenzhen UniversityAbstract Optically active nanostructures consisting of organic compounds and metallic support have shown great promise in phototherapy due to their increased light absorption capacity and high energy conversion. Herein, we conjugated chlorophyll (Chl) to vanadium carbide (V2C) nanosheets for combined photodynamic/photothermal therapy (PDT/PTT), which reserves the advantages of each modality while minimizing the side effects to achieve an improved therapeutic effect. In this system, the Chl from Leptolyngbya JSC-1 extracts acted as an efficient light-harvest antenna in a wide NIR range and photosensitizers (PSs) for oxygen self-generation hypoxia-relief PDT. The available large surface of two-dimensional (2D) V2C showed high Chl loading efficiency, and the interaction between organic Chl and metallic V2C led to energy conversion efficiency high to 78%. Thus, the Chl/ V2C nanostructure showed advanced performance in vitro cell line killing and completely ablated tumors in vivo with 100% survival rate under a single NIR irradiation. Our results suggest that the artificial optical Chl/V2C nanostructure will benefit photocatalytic tumor eradication clinic application. Graphical Abstracthttps://doi.org/10.1186/s12951-022-01331-xOptically active nanostructuresPhotothermal therapyPhotodynamic therapyChlorophyllVanadium carbide |
| spellingShingle | Huiting Lu Shah Zada Songsong Tang Cheng Yaru Wei Wei Qiao Yuchun Qiqi Yang Jinya Du Pengcheng Fu Haifeng Dong Xueji Zhang RETRACTED ARTICLE: Artificial photoactive chlorophyll conjugated vanadium carbide nanostructure for synergistic photothermal/photodynamic therapy of cancer Journal of Nanobiotechnology Optically active nanostructures Photothermal therapy Photodynamic therapy Chlorophyll Vanadium carbide |
| title | RETRACTED ARTICLE: Artificial photoactive chlorophyll conjugated vanadium carbide nanostructure for synergistic photothermal/photodynamic therapy of cancer |
| title_full | RETRACTED ARTICLE: Artificial photoactive chlorophyll conjugated vanadium carbide nanostructure for synergistic photothermal/photodynamic therapy of cancer |
| title_fullStr | RETRACTED ARTICLE: Artificial photoactive chlorophyll conjugated vanadium carbide nanostructure for synergistic photothermal/photodynamic therapy of cancer |
| title_full_unstemmed | RETRACTED ARTICLE: Artificial photoactive chlorophyll conjugated vanadium carbide nanostructure for synergistic photothermal/photodynamic therapy of cancer |
| title_short | RETRACTED ARTICLE: Artificial photoactive chlorophyll conjugated vanadium carbide nanostructure for synergistic photothermal/photodynamic therapy of cancer |
| title_sort | retracted article artificial photoactive chlorophyll conjugated vanadium carbide nanostructure for synergistic photothermal photodynamic therapy of cancer |
| topic | Optically active nanostructures Photothermal therapy Photodynamic therapy Chlorophyll Vanadium carbide |
| url | https://doi.org/10.1186/s12951-022-01331-x |
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