Mitochondrial complex I subunit MT-ND1 mutations affect disease progression
Mitochondrial respiratory chain complex I is an important component of the oxidative respiratory chain, with the mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 (MT-ND1) being one of the core subunits. MT-ND1 plays a role in the assembly of complex I and its enzymatic function....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024048394 |
| _version_ | 1797230557291085824 |
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| author | Xi Lin Yanhong Zhou Lei Xue |
| author_facet | Xi Lin Yanhong Zhou Lei Xue |
| author_sort | Xi Lin |
| collection | DOAJ |
| description | Mitochondrial respiratory chain complex I is an important component of the oxidative respiratory chain, with the mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 (MT-ND1) being one of the core subunits. MT-ND1 plays a role in the assembly of complex I and its enzymatic function. MT-ND1 gene mutation affects pathophysiological processes, such as interfering with the early assembly of complex I, affecting the ubiquinone binding domain and proton channel of complex I, and affecting oxidative phosphorylation, thus leading to the occurrence of diseases. The relationship between MT-ND1 gene mutation and disease has been has received increasing research attention. Therefore, this article reviews the impact of MT-ND1 mutations on disease progression, focusing on the impact of such mutations on diseases and their possible mechanisms, as well as the application of targeting MT-ND1 gene mutations in disease diagnosis and treatment. We aim to provide a new perspective leading to a more comprehensive understanding of the relationship between MT-ND1 gene mutations and diseases. |
| first_indexed | 2024-04-24T15:30:23Z |
| format | Article |
| id | doaj.art-d8001a8c0b764713b82eb17d39a63e0e |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T15:30:23Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-d8001a8c0b764713b82eb17d39a63e0e2024-04-02T04:15:21ZengElsevierHeliyon2405-84402024-04-01107e28808Mitochondrial complex I subunit MT-ND1 mutations affect disease progressionXi Lin0Yanhong Zhou1Lei Xue2Department of Pathology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China; Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan 410078, ChinaCancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan 410078, China; Corresponding author.Department of Pathology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China; Corresponding author.Mitochondrial respiratory chain complex I is an important component of the oxidative respiratory chain, with the mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 (MT-ND1) being one of the core subunits. MT-ND1 plays a role in the assembly of complex I and its enzymatic function. MT-ND1 gene mutation affects pathophysiological processes, such as interfering with the early assembly of complex I, affecting the ubiquinone binding domain and proton channel of complex I, and affecting oxidative phosphorylation, thus leading to the occurrence of diseases. The relationship between MT-ND1 gene mutation and disease has been has received increasing research attention. Therefore, this article reviews the impact of MT-ND1 mutations on disease progression, focusing on the impact of such mutations on diseases and their possible mechanisms, as well as the application of targeting MT-ND1 gene mutations in disease diagnosis and treatment. We aim to provide a new perspective leading to a more comprehensive understanding of the relationship between MT-ND1 gene mutations and diseases.http://www.sciencedirect.com/science/article/pii/S2405844024048394Mitochondrial complex IMT-ND1MutationPathological mutationLHONType 2 diabetes |
| spellingShingle | Xi Lin Yanhong Zhou Lei Xue Mitochondrial complex I subunit MT-ND1 mutations affect disease progression Heliyon Mitochondrial complex I MT-ND1 Mutation Pathological mutation LHON Type 2 diabetes |
| title | Mitochondrial complex I subunit MT-ND1 mutations affect disease progression |
| title_full | Mitochondrial complex I subunit MT-ND1 mutations affect disease progression |
| title_fullStr | Mitochondrial complex I subunit MT-ND1 mutations affect disease progression |
| title_full_unstemmed | Mitochondrial complex I subunit MT-ND1 mutations affect disease progression |
| title_short | Mitochondrial complex I subunit MT-ND1 mutations affect disease progression |
| title_sort | mitochondrial complex i subunit mt nd1 mutations affect disease progression |
| topic | Mitochondrial complex I MT-ND1 Mutation Pathological mutation LHON Type 2 diabetes |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024048394 |
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