IL-1 family cytokines trigger sterile inflammatory disease
Inflammation plays vital roles in protective responses against pathogens and tissue repair, however improper resolution of inflammatory networks is centrally involved in the pathogenesis of many acute and chronic diseases. Extensive advances have been made in recent years to define the inflammatory...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-10-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00315/full |
| _version_ | 1818515817491333120 |
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| author | John R Lukens Jordan M Gross Thirumala-Devi eKanneganti |
| author_facet | John R Lukens Jordan M Gross Thirumala-Devi eKanneganti |
| author_sort | John R Lukens |
| collection | DOAJ |
| description | Inflammation plays vital roles in protective responses against pathogens and tissue repair, however improper resolution of inflammatory networks is centrally involved in the pathogenesis of many acute and chronic diseases. Extensive advances have been made in recent years to define the inflammatory processes that are required for pathogen clearance, however in comparison, less is known about the regulation of inflammation in sterile settings. Over the past decade non-communicable chronic diseases that are potentiated by sterile inflammation have replaced infectious diseases as the major threat to global human health. Thus, improved understanding of the sterile inflammatory process has emerged as one of the most important areas of biomedical investigation during our time. In this review we highlight the central role that interleukin-1 (IL-1) family cytokines play in sterile inflammatory diseases. |
| first_indexed | 2024-12-11T00:33:48Z |
| format | Article |
| id | doaj.art-d8008581aaf143d2804d4094a0624839 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T00:33:48Z |
| publishDate | 2012-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d8008581aaf143d2804d4094a06248392022-12-22T01:27:15ZengFrontiers Media S.A.Frontiers in Immunology1664-32242012-10-01310.3389/fimmu.2012.0031533180IL-1 family cytokines trigger sterile inflammatory diseaseJohn R Lukens0Jordan M Gross1Thirumala-Devi eKanneganti2St. Jude Children's Research HospitalSt. Jude Children's Research HospitalSt. Jude Children's Research HospitalInflammation plays vital roles in protective responses against pathogens and tissue repair, however improper resolution of inflammatory networks is centrally involved in the pathogenesis of many acute and chronic diseases. Extensive advances have been made in recent years to define the inflammatory processes that are required for pathogen clearance, however in comparison, less is known about the regulation of inflammation in sterile settings. Over the past decade non-communicable chronic diseases that are potentiated by sterile inflammation have replaced infectious diseases as the major threat to global human health. Thus, improved understanding of the sterile inflammatory process has emerged as one of the most important areas of biomedical investigation during our time. In this review we highlight the central role that interleukin-1 (IL-1) family cytokines play in sterile inflammatory diseases.http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00315/fullArthritisAtherosclerosisMultiple SclerosisNeurodegenerative DiseasesObesityIL-1 |
| spellingShingle | John R Lukens Jordan M Gross Thirumala-Devi eKanneganti IL-1 family cytokines trigger sterile inflammatory disease Frontiers in Immunology Arthritis Atherosclerosis Multiple Sclerosis Neurodegenerative Diseases Obesity IL-1 |
| title | IL-1 family cytokines trigger sterile inflammatory disease |
| title_full | IL-1 family cytokines trigger sterile inflammatory disease |
| title_fullStr | IL-1 family cytokines trigger sterile inflammatory disease |
| title_full_unstemmed | IL-1 family cytokines trigger sterile inflammatory disease |
| title_short | IL-1 family cytokines trigger sterile inflammatory disease |
| title_sort | il 1 family cytokines trigger sterile inflammatory disease |
| topic | Arthritis Atherosclerosis Multiple Sclerosis Neurodegenerative Diseases Obesity IL-1 |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00315/full |
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