Trends in the Incidence and Survival Rates of Primary Ovarian Clear Cell Carcinoma Compared to Ovarian Serous Carcinoma in Korea
ObjectiveTo compare the incidence and survival rates of primary ovarian clear cell carcinoma (OCCC) and ovarian serous carcinoma (OSC) from a nationwide collected database.MethodsWe extracted information of patients with primary OCCC and OSC from the Korea Central Cancer Registry recorded between 19...
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| Format: | Članak |
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Frontiers Media S.A.
2022-04-01
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| Serija: | Frontiers in Oncology |
| Teme: | |
| Online pristup: | https://www.frontiersin.org/articles/10.3389/fonc.2022.874037/full |
| _version_ | 1828921661418635264 |
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| author | Se Ik Kim Hyeong In Ha Kyung Jin Eoh Jiwon Lim Young-Joo Won Young-Joo Won Myong Cheol Lim Myong Cheol Lim Myong Cheol Lim |
| author_facet | Se Ik Kim Hyeong In Ha Kyung Jin Eoh Jiwon Lim Young-Joo Won Young-Joo Won Myong Cheol Lim Myong Cheol Lim Myong Cheol Lim |
| author_sort | Se Ik Kim |
| collection | DOAJ |
| description | ObjectiveTo compare the incidence and survival rates of primary ovarian clear cell carcinoma (OCCC) and ovarian serous carcinoma (OSC) from a nationwide collected database.MethodsWe extracted information of patients with primary OCCC and OSC from the Korea Central Cancer Registry recorded between 1999 and 2018, including age at diagnosis and the Surveillance, Epidemiology, and End Results summary stage. Age-standardized incidence rates (ASRs) and annual percent changes (APCs) were calculated. Baseline characteristics and overall survival (OS) were compared between the OCCC and OSC groups.ResultsOverall, the incidence rate of primary OCCC increased markedly from 1999 (ASR, 0.16/100,000) to 2018 (0.76/100,000) (APC, 7.85%; P<0.0001). Patients with OCCC were significantly younger and had early-stage disease more frequently than those with OSC. Patients diagnosed with OCCC before the age of 50 showed better OS than those diagnosed after the age of 50 (P=0.0048). The 5-year OS of the OCCC group did not differ by study period [73.5% (1999–2008) vs. 75.4% (2009–2018), P=0.3187], whereas the 5-year OS of the OSC group improved from 54.4% to 58% (P=0.0003).ConclusionsOur nationwide registry-based study demonstrated that the incidence of OCCC in Korea increased significantly from 1999 to 2018. Early-stage OCCC had a relatively good prognosis, but advanced-stage OCCC had a worse OS than advanced-stage OSC. Therefore, the development of optimal treatment strategies for OCCC is warranted. |
| first_indexed | 2024-12-13T22:06:43Z |
| format | Article |
| id | doaj.art-d8010e426d0e4ad1b39e05b51eaa7eb4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-13T22:06:43Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-d8010e426d0e4ad1b39e05b51eaa7eb42022-12-21T23:29:49ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-04-011210.3389/fonc.2022.874037874037Trends in the Incidence and Survival Rates of Primary Ovarian Clear Cell Carcinoma Compared to Ovarian Serous Carcinoma in KoreaSe Ik Kim0Hyeong In Ha1Kyung Jin Eoh2Jiwon Lim3Young-Joo Won4Young-Joo Won5Myong Cheol Lim6Myong Cheol Lim7Myong Cheol Lim8Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South KoreaDepartment of Obstetrics and Gynecology, Pusan National University Yangsan Hospital, Yangsan, South KoreaDepartment of Obstetrics and Gynecology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South KoreaDivision of Cancer Registration and Surveillance, National Cancer Center, Goyang, South KoreaDivision of Cancer Registration and Surveillance, National Cancer Center, Goyang, South KoreaDepartment of Health Administration, Yonsei University, Wonju, South KoreaCenter for Gynecologic Cancer and Center for Clinical Trial, Hospital, National Cancer Center, Goyang, South KoreaDepartment of Cancer Control and Policy, National Cancer Center Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, South KoreaRare & Pediatric Cancer Branch and Immuno-oncology Branch, Division of Rare and Refractory Cancer, Research Institute, National Cancer Center, Goyang, South KoreaObjectiveTo compare the incidence and survival rates of primary ovarian clear cell carcinoma (OCCC) and ovarian serous carcinoma (OSC) from a nationwide collected database.MethodsWe extracted information of patients with primary OCCC and OSC from the Korea Central Cancer Registry recorded between 1999 and 2018, including age at diagnosis and the Surveillance, Epidemiology, and End Results summary stage. Age-standardized incidence rates (ASRs) and annual percent changes (APCs) were calculated. Baseline characteristics and overall survival (OS) were compared between the OCCC and OSC groups.ResultsOverall, the incidence rate of primary OCCC increased markedly from 1999 (ASR, 0.16/100,000) to 2018 (0.76/100,000) (APC, 7.85%; P<0.0001). Patients with OCCC were significantly younger and had early-stage disease more frequently than those with OSC. Patients diagnosed with OCCC before the age of 50 showed better OS than those diagnosed after the age of 50 (P=0.0048). The 5-year OS of the OCCC group did not differ by study period [73.5% (1999–2008) vs. 75.4% (2009–2018), P=0.3187], whereas the 5-year OS of the OSC group improved from 54.4% to 58% (P=0.0003).ConclusionsOur nationwide registry-based study demonstrated that the incidence of OCCC in Korea increased significantly from 1999 to 2018. Early-stage OCCC had a relatively good prognosis, but advanced-stage OCCC had a worse OS than advanced-stage OSC. Therefore, the development of optimal treatment strategies for OCCC is warranted.https://www.frontiersin.org/articles/10.3389/fonc.2022.874037/fullovarian cancerhistologic subtypeclear cell carcinomaserous carcinomaincidencesurvival |
| spellingShingle | Se Ik Kim Hyeong In Ha Kyung Jin Eoh Jiwon Lim Young-Joo Won Young-Joo Won Myong Cheol Lim Myong Cheol Lim Myong Cheol Lim Trends in the Incidence and Survival Rates of Primary Ovarian Clear Cell Carcinoma Compared to Ovarian Serous Carcinoma in Korea Frontiers in Oncology ovarian cancer histologic subtype clear cell carcinoma serous carcinoma incidence survival |
| title | Trends in the Incidence and Survival Rates of Primary Ovarian Clear Cell Carcinoma Compared to Ovarian Serous Carcinoma in Korea |
| title_full | Trends in the Incidence and Survival Rates of Primary Ovarian Clear Cell Carcinoma Compared to Ovarian Serous Carcinoma in Korea |
| title_fullStr | Trends in the Incidence and Survival Rates of Primary Ovarian Clear Cell Carcinoma Compared to Ovarian Serous Carcinoma in Korea |
| title_full_unstemmed | Trends in the Incidence and Survival Rates of Primary Ovarian Clear Cell Carcinoma Compared to Ovarian Serous Carcinoma in Korea |
| title_short | Trends in the Incidence and Survival Rates of Primary Ovarian Clear Cell Carcinoma Compared to Ovarian Serous Carcinoma in Korea |
| title_sort | trends in the incidence and survival rates of primary ovarian clear cell carcinoma compared to ovarian serous carcinoma in korea |
| topic | ovarian cancer histologic subtype clear cell carcinoma serous carcinoma incidence survival |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.874037/full |
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