Interleukin 10 gene polymorphisms and frailty syndrome in elderly Mexican people: (Sadem study)
Abstract Frailty is a geriatric syndrome, characterized by a loss in functional reserve with an increase in morbidity and mortality. There are no reports that link the genetic polymorphisms between interleukin 10 (IL10) and frailty; for this reason, our objective was used to analyze the role of the...
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| Format: | Article |
| Language: | English |
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Wiley
2019-09-01
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| Series: | Molecular Genetics & Genomic Medicine |
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| Online Access: | https://doi.org/10.1002/mgg3.918 |
| _version_ | 1811218946223767552 |
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| author | Teresa Juárez‐Cedillo Gilberto Vargas‐Alarcón Nancy Martínez‐Rodríguez Enrique Juárez‐Cedillo José Manuel Fragoso Jorge Escobedo‐de‐la‐Peña |
| author_facet | Teresa Juárez‐Cedillo Gilberto Vargas‐Alarcón Nancy Martínez‐Rodríguez Enrique Juárez‐Cedillo José Manuel Fragoso Jorge Escobedo‐de‐la‐Peña |
| author_sort | Teresa Juárez‐Cedillo |
| collection | DOAJ |
| description | Abstract Frailty is a geriatric syndrome, characterized by a loss in functional reserve with an increase in morbidity and mortality. There are no reports that link the genetic polymorphisms between interleukin 10 (IL10) and frailty; for this reason, our objective was used to analyze the role of the polymorphisms of IL10 (rs1800896, rs1800871) in the susceptibility to frailty in a Mexican population. Our study included 984 participants divided into 368 nonfrail, 309 prefrail, and 307 frail. The models for the polymorphisms rs1800896 and rs1800871 were recessive models in association with frailty (OR = 2.3, CI 95% = 1.6–3.2; OR = 1.53, CI 95% = 1.0–2.6), respectively. Two risk haplotypes were identified: ACG and CCG (p < .0001), and three protective haplotypes were identified: ACA, ATG, and ATA (p < .05). This study evaluated the relationship between IL10 and the three subtypes of this geriatric syndrome (frail, prefrail, and nonfrail). These results support a greater susceptibility to frailty for the minor alleles of rs1800871 and rs1800896. In addition, we found two risk haplotypes supporting the participation of the IL10 in the susceptibility for frailty in the Mexican population. |
| first_indexed | 2024-04-12T07:17:45Z |
| format | Article |
| id | doaj.art-d80180372fca424e867cc3ea44618572 |
| institution | Directory Open Access Journal |
| issn | 2324-9269 |
| language | English |
| last_indexed | 2024-04-12T07:17:45Z |
| publishDate | 2019-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj.art-d80180372fca424e867cc3ea446185722022-12-22T03:42:26ZengWileyMolecular Genetics & Genomic Medicine2324-92692019-09-0179n/an/a10.1002/mgg3.918Interleukin 10 gene polymorphisms and frailty syndrome in elderly Mexican people: (Sadem study)Teresa Juárez‐Cedillo0Gilberto Vargas‐Alarcón1Nancy Martínez‐Rodríguez2Enrique Juárez‐Cedillo3José Manuel Fragoso4Jorge Escobedo‐de‐la‐Peña5Comisionada en la Unidad de investigación en Epidemiologia Clínica, Hospital Regional No. 1, Dr. Carlos McGregor Sánchez Navarro, Instituto Mexicano del Seguro Social Mexico City MexicoDepartamento de Biología Molecular. Instituto Nacional de Cardiología Ignacio Chávez, (SSA) Mexico City MexicoCommunity Health Research. Department Hospital Infantil de Mexico Federico Gomez; (SSA) Mexico City MexicoDepartamento de Biología Molecular. Instituto Nacional de Cardiología Ignacio Chávez, (SSA) Mexico City MexicoDepartamento de Biología Molecular. Instituto Nacional de Cardiología Ignacio Chávez, (SSA) Mexico City MexicoUnidad de investigación en Epidemiologia Clínica Hospital Regional No. 1, Dr. Carlos McGregor Sánchez Navarro, Instituto Mexicano del Seguro Social México City MéxicoAbstract Frailty is a geriatric syndrome, characterized by a loss in functional reserve with an increase in morbidity and mortality. There are no reports that link the genetic polymorphisms between interleukin 10 (IL10) and frailty; for this reason, our objective was used to analyze the role of the polymorphisms of IL10 (rs1800896, rs1800871) in the susceptibility to frailty in a Mexican population. Our study included 984 participants divided into 368 nonfrail, 309 prefrail, and 307 frail. The models for the polymorphisms rs1800896 and rs1800871 were recessive models in association with frailty (OR = 2.3, CI 95% = 1.6–3.2; OR = 1.53, CI 95% = 1.0–2.6), respectively. Two risk haplotypes were identified: ACG and CCG (p < .0001), and three protective haplotypes were identified: ACA, ATG, and ATA (p < .05). This study evaluated the relationship between IL10 and the three subtypes of this geriatric syndrome (frail, prefrail, and nonfrail). These results support a greater susceptibility to frailty for the minor alleles of rs1800871 and rs1800896. In addition, we found two risk haplotypes supporting the participation of the IL10 in the susceptibility for frailty in the Mexican population.https://doi.org/10.1002/mgg3.918frailtygeriatric syndromehaplotypesinterleukinpolymorphisms |
| spellingShingle | Teresa Juárez‐Cedillo Gilberto Vargas‐Alarcón Nancy Martínez‐Rodríguez Enrique Juárez‐Cedillo José Manuel Fragoso Jorge Escobedo‐de‐la‐Peña Interleukin 10 gene polymorphisms and frailty syndrome in elderly Mexican people: (Sadem study) Molecular Genetics & Genomic Medicine frailty geriatric syndrome haplotypes interleukin polymorphisms |
| title | Interleukin 10 gene polymorphisms and frailty syndrome in elderly Mexican people: (Sadem study) |
| title_full | Interleukin 10 gene polymorphisms and frailty syndrome in elderly Mexican people: (Sadem study) |
| title_fullStr | Interleukin 10 gene polymorphisms and frailty syndrome in elderly Mexican people: (Sadem study) |
| title_full_unstemmed | Interleukin 10 gene polymorphisms and frailty syndrome in elderly Mexican people: (Sadem study) |
| title_short | Interleukin 10 gene polymorphisms and frailty syndrome in elderly Mexican people: (Sadem study) |
| title_sort | interleukin 10 gene polymorphisms and frailty syndrome in elderly mexican people sadem study |
| topic | frailty geriatric syndrome haplotypes interleukin polymorphisms |
| url | https://doi.org/10.1002/mgg3.918 |
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