Preterm Infants on Early Solid Foods and Iron Status in the First Year of Life—A Secondary Outcome Analysis of a Randomized Controlled Trial
Introduction of solid foods and iron status in the first year of life of preterm infants are highly discussed topics. The aim of this study was to examine whether two timepoints of introduction of standardized solid foods in preterm infants have an impact on ferritin and other hematologic parameters...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/13/2732 |
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| author | Margarita Thanhaeuser Fabian Eibensteiner Margit Kornsteiner-Krenn Melanie Gsoellpointner Sophia Brandstetter Renate Fuiko Ursula Koeller Wolfgang Huf Mercedes Huber-Dangl Christoph Binder Alexandra Thajer Bernd Jilma Angelika Berger Nadja Haiden |
| author_facet | Margarita Thanhaeuser Fabian Eibensteiner Margit Kornsteiner-Krenn Melanie Gsoellpointner Sophia Brandstetter Renate Fuiko Ursula Koeller Wolfgang Huf Mercedes Huber-Dangl Christoph Binder Alexandra Thajer Bernd Jilma Angelika Berger Nadja Haiden |
| author_sort | Margarita Thanhaeuser |
| collection | DOAJ |
| description | Introduction of solid foods and iron status in the first year of life of preterm infants are highly discussed topics. The aim of this study was to examine whether two timepoints of introduction of standardized solid foods in preterm infants have an impact on ferritin and other hematologic parameters important for iron status in the first year of life. This is a secondary outcome analysis of a prospective, randomized intervention trial in very low birth weight (VLBW) infants randomized to an early (10–12th week corrected age) or a late (16–18th week corrected age) complementary feeding group. Iron status was assessed with blood samples taken at 6 weeks, 6 months, and 12 months corrected age. In total, 177 infants were randomized (early group: <i>n</i> = 89, late group: <i>n</i> = 88). Ferritin showed no differences between study groups throughout the first year of life, as did all other parameters associated with iron status. At 12 months corrected age, the incidence of iron deficiency was significantly higher in the early feeding group. There is room for improvement of iron status in VLBW preterm infants, regular blood checks should be introduced, and current recommendations may need to be a reconsidered. |
| first_indexed | 2024-03-09T03:58:55Z |
| format | Article |
| id | doaj.art-d80280c2978d4a70bcc38dbc4b956ec1 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T03:58:55Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-d80280c2978d4a70bcc38dbc4b956ec12023-12-03T14:16:54ZengMDPI AGNutrients2072-66432022-06-011413273210.3390/nu14132732Preterm Infants on Early Solid Foods and Iron Status in the First Year of Life—A Secondary Outcome Analysis of a Randomized Controlled TrialMargarita Thanhaeuser0Fabian Eibensteiner1Margit Kornsteiner-Krenn2Melanie Gsoellpointner3Sophia Brandstetter4Renate Fuiko5Ursula Koeller6Wolfgang Huf7Mercedes Huber-Dangl8Christoph Binder9Alexandra Thajer10Bernd Jilma11Angelika Berger12Nadja Haiden13Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Laboratory Medicine, Klinik Hietzing, Wiener Gesundheitsverbund, 1130 Vienna, AustriaDepartment of Laboratory Medicine, Klinik Hietzing, Wiener Gesundheitsverbund, 1130 Vienna, AustriaDepartment of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, AustriaIntroduction of solid foods and iron status in the first year of life of preterm infants are highly discussed topics. The aim of this study was to examine whether two timepoints of introduction of standardized solid foods in preterm infants have an impact on ferritin and other hematologic parameters important for iron status in the first year of life. This is a secondary outcome analysis of a prospective, randomized intervention trial in very low birth weight (VLBW) infants randomized to an early (10–12th week corrected age) or a late (16–18th week corrected age) complementary feeding group. Iron status was assessed with blood samples taken at 6 weeks, 6 months, and 12 months corrected age. In total, 177 infants were randomized (early group: <i>n</i> = 89, late group: <i>n</i> = 88). Ferritin showed no differences between study groups throughout the first year of life, as did all other parameters associated with iron status. At 12 months corrected age, the incidence of iron deficiency was significantly higher in the early feeding group. There is room for improvement of iron status in VLBW preterm infants, regular blood checks should be introduced, and current recommendations may need to be a reconsidered.https://www.mdpi.com/2072-6643/14/13/2732preterm infantsolid foodsiron statusiron intake |
| spellingShingle | Margarita Thanhaeuser Fabian Eibensteiner Margit Kornsteiner-Krenn Melanie Gsoellpointner Sophia Brandstetter Renate Fuiko Ursula Koeller Wolfgang Huf Mercedes Huber-Dangl Christoph Binder Alexandra Thajer Bernd Jilma Angelika Berger Nadja Haiden Preterm Infants on Early Solid Foods and Iron Status in the First Year of Life—A Secondary Outcome Analysis of a Randomized Controlled Trial Nutrients preterm infant solid foods iron status iron intake |
| title | Preterm Infants on Early Solid Foods and Iron Status in the First Year of Life—A Secondary Outcome Analysis of a Randomized Controlled Trial |
| title_full | Preterm Infants on Early Solid Foods and Iron Status in the First Year of Life—A Secondary Outcome Analysis of a Randomized Controlled Trial |
| title_fullStr | Preterm Infants on Early Solid Foods and Iron Status in the First Year of Life—A Secondary Outcome Analysis of a Randomized Controlled Trial |
| title_full_unstemmed | Preterm Infants on Early Solid Foods and Iron Status in the First Year of Life—A Secondary Outcome Analysis of a Randomized Controlled Trial |
| title_short | Preterm Infants on Early Solid Foods and Iron Status in the First Year of Life—A Secondary Outcome Analysis of a Randomized Controlled Trial |
| title_sort | preterm infants on early solid foods and iron status in the first year of life a secondary outcome analysis of a randomized controlled trial |
| topic | preterm infant solid foods iron status iron intake |
| url | https://www.mdpi.com/2072-6643/14/13/2732 |
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