The role of adipokines and ghrelin in interactions and clinical implications in childhood obesity
BACKGROUND: Childhood obesity is a growing global health concern, especially prevalent in the Arabian Peninsula, and is known to contribute to metabolic syndrome and insulin resistance. This study aimed to investigate the interplay between adipokines (leptin and adiponectin), ghrelin, and insulin ho...
| Main Authors: | , , |
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| Format: | Article |
| Sprog: | English |
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Wolters Kluwer Medknow Publications
2024-02-01
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| Serier: | Journal of Education and Health Promotion |
| Fag: | |
| Online adgang: | https://journals.lww.com/10.4103/jehp.jehp_972_23 |
| _version_ | 1827168804167221248 |
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| author | Karrar Haider Haddawi Ahmed Ghdhban Al-Ziaydi Fatima Abd Al-Kathem Al-Khalidi |
| author_facet | Karrar Haider Haddawi Ahmed Ghdhban Al-Ziaydi Fatima Abd Al-Kathem Al-Khalidi |
| author_sort | Karrar Haider Haddawi |
| collection | DOAJ |
| description | BACKGROUND:
Childhood obesity is a growing global health concern, especially prevalent in the Arabian Peninsula, and is known to contribute to metabolic syndrome and insulin resistance. This study aimed to investigate the interplay between adipokines (leptin and adiponectin), ghrelin, and insulin homeostasis in childhood obesity.
MATERIAL AND METHODS:
A case–control study was conducted in Babylon involving 120 children/adolescents (7–17 years). The participants were divided into two groups: 60 obese and 60 healthy controls. Anthropometric and biochemical measures were examined, applying World Health Organization (WHO) growth standards to categorize weight status. Data on blood lipids, glucose, adipokines, and ghrelin were collected in Babylon (Merjan Medical City), ensuring accuracy and providing insights into pediatric obesity’s metabolic and hormonal status.
RESULT:
Clinical, anthropometric, and laboratory attributes of children were evaluated, with classification as normal-weight or obese based on BMI/Z-score and Waist Circumference. The obese group exhibited elevated triglycerides and insulin levels, as well as reduced adiponectin levels (P ≤ 0.001). Leptin levels showed a positive correlation with BMI/Z-score (r = 0.352, P = 0.006). A diagnostic model demonstrated the significant diagnostic capacity of leptin (AUC > 99%) and its importance in predicting childhood obesity. Each unit increase in leptin elevated the probability of obesity by a factor of 1.197 (95% CI: 1.0507–1.3632, P = 0.0068).
CONCLUSION:
The study revealed significant differences in clinical, biochemical, and biological markers of obesity between the research groups and the control group. Leptin emerged as a significant predictor of obesity, demonstrating high diagnostic accuracy. The complex interactions among these adipokines underscore the necessity for comprehensive obesity management strategies. |
| first_indexed | 2024-04-24T19:42:27Z |
| format | Article |
| id | doaj.art-d8032e9f8ec74beea99db045baeaa65d |
| institution | Directory Open Access Journal |
| issn | 2277-9531 2319-6440 |
| language | English |
| last_indexed | 2025-03-21T02:26:00Z |
| publishDate | 2024-02-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Education and Health Promotion |
| spelling | doaj.art-d8032e9f8ec74beea99db045baeaa65d2024-08-02T14:45:30ZengWolters Kluwer Medknow PublicationsJournal of Education and Health Promotion2277-95312319-64402024-02-01131404010.4103/jehp.jehp_972_23The role of adipokines and ghrelin in interactions and clinical implications in childhood obesityKarrar Haider HaddawiAhmed Ghdhban Al-ZiaydiFatima Abd Al-Kathem Al-KhalidiBACKGROUND: Childhood obesity is a growing global health concern, especially prevalent in the Arabian Peninsula, and is known to contribute to metabolic syndrome and insulin resistance. This study aimed to investigate the interplay between adipokines (leptin and adiponectin), ghrelin, and insulin homeostasis in childhood obesity. MATERIAL AND METHODS: A case–control study was conducted in Babylon involving 120 children/adolescents (7–17 years). The participants were divided into two groups: 60 obese and 60 healthy controls. Anthropometric and biochemical measures were examined, applying World Health Organization (WHO) growth standards to categorize weight status. Data on blood lipids, glucose, adipokines, and ghrelin were collected in Babylon (Merjan Medical City), ensuring accuracy and providing insights into pediatric obesity’s metabolic and hormonal status. RESULT: Clinical, anthropometric, and laboratory attributes of children were evaluated, with classification as normal-weight or obese based on BMI/Z-score and Waist Circumference. The obese group exhibited elevated triglycerides and insulin levels, as well as reduced adiponectin levels (P ≤ 0.001). Leptin levels showed a positive correlation with BMI/Z-score (r = 0.352, P = 0.006). A diagnostic model demonstrated the significant diagnostic capacity of leptin (AUC > 99%) and its importance in predicting childhood obesity. Each unit increase in leptin elevated the probability of obesity by a factor of 1.197 (95% CI: 1.0507–1.3632, P = 0.0068). CONCLUSION: The study revealed significant differences in clinical, biochemical, and biological markers of obesity between the research groups and the control group. Leptin emerged as a significant predictor of obesity, demonstrating high diagnostic accuracy. The complex interactions among these adipokines underscore the necessity for comprehensive obesity management strategies.https://journals.lww.com/10.4103/jehp.jehp_972_23adipokinesadiponectinanthropometrychildhood obesityinsulin resistanceleptin |
| spellingShingle | Karrar Haider Haddawi Ahmed Ghdhban Al-Ziaydi Fatima Abd Al-Kathem Al-Khalidi The role of adipokines and ghrelin in interactions and clinical implications in childhood obesity Journal of Education and Health Promotion adipokines adiponectin anthropometry childhood obesity insulin resistance leptin |
| title | The role of adipokines and ghrelin in interactions and clinical implications in childhood obesity |
| title_full | The role of adipokines and ghrelin in interactions and clinical implications in childhood obesity |
| title_fullStr | The role of adipokines and ghrelin in interactions and clinical implications in childhood obesity |
| title_full_unstemmed | The role of adipokines and ghrelin in interactions and clinical implications in childhood obesity |
| title_short | The role of adipokines and ghrelin in interactions and clinical implications in childhood obesity |
| title_sort | role of adipokines and ghrelin in interactions and clinical implications in childhood obesity |
| topic | adipokines adiponectin anthropometry childhood obesity insulin resistance leptin |
| url | https://journals.lww.com/10.4103/jehp.jehp_972_23 |
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