The copper-associated protein STEAP2 correlated with glioma prognosis and immune infiltration
High-grade glioma is characterized by cell heterogeneity, gene mutations, and poor prognosis. Abnormal copper homeostasis affects the pathogenesis of glioma, but the underlying mechanisms and involved proteins are unknown. Here, we selected 90 copper-related proteins and verified their expression di...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2022.944682/full |
| _version_ | 1811214692855578624 |
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| author | Xu Wang Xu Wang Mingzhi Han Mingzhi Han Mingzhi Han Songyu Chen Yanfei Sun Yanfei Sun Ruirong Tan Bin Huang Bin Huang |
| author_facet | Xu Wang Xu Wang Mingzhi Han Mingzhi Han Mingzhi Han Songyu Chen Yanfei Sun Yanfei Sun Ruirong Tan Bin Huang Bin Huang |
| author_sort | Xu Wang |
| collection | DOAJ |
| description | High-grade glioma is characterized by cell heterogeneity, gene mutations, and poor prognosis. Abnormal copper homeostasis affects the pathogenesis of glioma, but the underlying mechanisms and involved proteins are unknown. Here, we selected 90 copper-related proteins and verified their expression differences in glioma and normal tissues in the TCGA cohort followed by GO and KEGG clustering analyses. We then developed and validated a prognostic model. Moreover, we examined the mutation burden of copper-related proteins and discussed the differences in the immune microenvironment in the high- and low-risk groups. Furthermore, we focused on STEAP2 and demonstrated that STEAP2 expression was relatively low in tumor tissues compared to normal tissues, implying a favorable prognosis. Our findings provide a foundation for future research targeting copper-related proteins and their immune microenvironment to improve prognosis and responses to immunotherapy. |
| first_indexed | 2024-04-12T06:08:49Z |
| format | Article |
| id | doaj.art-d804e0543e4c4f53bf384d77497f902a |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-12T06:08:49Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-d804e0543e4c4f53bf384d77497f902a2022-12-22T03:44:46ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022022-08-011610.3389/fncel.2022.944682944682The copper-associated protein STEAP2 correlated with glioma prognosis and immune infiltrationXu Wang0Xu Wang1Mingzhi Han2Mingzhi Han3Mingzhi Han4Songyu Chen5Yanfei Sun6Yanfei Sun7Ruirong Tan8Bin Huang9Bin Huang10Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, ChinaJinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, ChinaJinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, ChinaMedical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Neurosurgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, ChinaJinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, ChinaTranslational Chinese Medicine Key Laboratory of Sichuan Province, Sichuan Institute for Translational Chinese Medicine, Sichuan Academy of Chinese Medicine Sciences, Chengdu, ChinaDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, ChinaJinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, ChinaHigh-grade glioma is characterized by cell heterogeneity, gene mutations, and poor prognosis. Abnormal copper homeostasis affects the pathogenesis of glioma, but the underlying mechanisms and involved proteins are unknown. Here, we selected 90 copper-related proteins and verified their expression differences in glioma and normal tissues in the TCGA cohort followed by GO and KEGG clustering analyses. We then developed and validated a prognostic model. Moreover, we examined the mutation burden of copper-related proteins and discussed the differences in the immune microenvironment in the high- and low-risk groups. Furthermore, we focused on STEAP2 and demonstrated that STEAP2 expression was relatively low in tumor tissues compared to normal tissues, implying a favorable prognosis. Our findings provide a foundation for future research targeting copper-related proteins and their immune microenvironment to improve prognosis and responses to immunotherapy.https://www.frontiersin.org/articles/10.3389/fncel.2022.944682/fullgliomacopper associated proteinSTEAP2immune infiltrationtumor mutation burden (TMB) |
| spellingShingle | Xu Wang Xu Wang Mingzhi Han Mingzhi Han Mingzhi Han Songyu Chen Yanfei Sun Yanfei Sun Ruirong Tan Bin Huang Bin Huang The copper-associated protein STEAP2 correlated with glioma prognosis and immune infiltration Frontiers in Cellular Neuroscience glioma copper associated protein STEAP2 immune infiltration tumor mutation burden (TMB) |
| title | The copper-associated protein STEAP2 correlated with glioma prognosis and immune infiltration |
| title_full | The copper-associated protein STEAP2 correlated with glioma prognosis and immune infiltration |
| title_fullStr | The copper-associated protein STEAP2 correlated with glioma prognosis and immune infiltration |
| title_full_unstemmed | The copper-associated protein STEAP2 correlated with glioma prognosis and immune infiltration |
| title_short | The copper-associated protein STEAP2 correlated with glioma prognosis and immune infiltration |
| title_sort | copper associated protein steap2 correlated with glioma prognosis and immune infiltration |
| topic | glioma copper associated protein STEAP2 immune infiltration tumor mutation burden (TMB) |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2022.944682/full |
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