Single-fiber electromyography in the orbicularis oculi muscle in patients with ocular myasthenia gravis symptoms: does abnormal jitter predict response to treatment?
Abstract Background Seronegative ocular myasthenia gravis (OMG) is diagnosed by ocular symptoms with supporting SFEMG, typically of frontalis or extensor digitorum muscles. We aimed to determine the sensitivity and specificity of orbicularis oculi SFEMG to diagnose and exclude myasthenia gravis and...
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| Format: | Article |
| Language: | English |
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BMC
2017-06-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12883-017-0891-5 |
| _version_ | 1819093186315812864 |
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| author | Goran Rakocevic Mark Moster Mary Kay Floeter |
| author_facet | Goran Rakocevic Mark Moster Mary Kay Floeter |
| author_sort | Goran Rakocevic |
| collection | DOAJ |
| description | Abstract Background Seronegative ocular myasthenia gravis (OMG) is diagnosed by ocular symptoms with supporting SFEMG, typically of frontalis or extensor digitorum muscles. We aimed to determine the sensitivity and specificity of orbicularis oculi SFEMG to diagnose and exclude myasthenia gravis and predict response to therapy. Methods Orbicularis oculi SFEMG studies were conducted in 142 consecutive patients with symptoms and/or findings of OMG and negative AChR antibody during the period of 5 years. Retrospective chart review was conducted 2 years after the SFEMG to determine whether treatments were given and responses to treatment. Results Orbicularis oculi SFEMG was abnormal in 31 patients and normal in 111 patients. Twenty-nine patients with abnormal SFEMG were treated, and 25 had a good response. Twenty-four patients with normal SFEMG received treatment; none responded to treatment or developed generalized myasthenia. Conclusion An abnormal orbicularis oculi SFEMG in patients with seronegative OMG has a high predictive value for response to therapy. Our study findings may affect the treatment decisions in practice and aid better management of myasthenic patients. |
| first_indexed | 2024-12-21T23:07:30Z |
| format | Article |
| id | doaj.art-d806c31e248747aa8b88bfae5551a18c |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-21T23:07:30Z |
| publishDate | 2017-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-d806c31e248747aa8b88bfae5551a18c2022-12-21T18:47:08ZengBMCBMC Neurology1471-23772017-06-011711310.1186/s12883-017-0891-5Single-fiber electromyography in the orbicularis oculi muscle in patients with ocular myasthenia gravis symptoms: does abnormal jitter predict response to treatment?Goran Rakocevic0Mark Moster1Mary Kay Floeter2Department of Neurology, Thomas Jefferson UniversityWills Eye Hospital, Thomas Jefferson UniversityEMG Section, National Institute of Neurological Disorders and Stroke, National Institutes of HealthAbstract Background Seronegative ocular myasthenia gravis (OMG) is diagnosed by ocular symptoms with supporting SFEMG, typically of frontalis or extensor digitorum muscles. We aimed to determine the sensitivity and specificity of orbicularis oculi SFEMG to diagnose and exclude myasthenia gravis and predict response to therapy. Methods Orbicularis oculi SFEMG studies were conducted in 142 consecutive patients with symptoms and/or findings of OMG and negative AChR antibody during the period of 5 years. Retrospective chart review was conducted 2 years after the SFEMG to determine whether treatments were given and responses to treatment. Results Orbicularis oculi SFEMG was abnormal in 31 patients and normal in 111 patients. Twenty-nine patients with abnormal SFEMG were treated, and 25 had a good response. Twenty-four patients with normal SFEMG received treatment; none responded to treatment or developed generalized myasthenia. Conclusion An abnormal orbicularis oculi SFEMG in patients with seronegative OMG has a high predictive value for response to therapy. Our study findings may affect the treatment decisions in practice and aid better management of myasthenic patients.http://link.springer.com/article/10.1186/s12883-017-0891-5PtosisDiplopiaSingle-fiber EMGNeuromuscular jitterAcetylcholine receptor antibody |
| spellingShingle | Goran Rakocevic Mark Moster Mary Kay Floeter Single-fiber electromyography in the orbicularis oculi muscle in patients with ocular myasthenia gravis symptoms: does abnormal jitter predict response to treatment? BMC Neurology Ptosis Diplopia Single-fiber EMG Neuromuscular jitter Acetylcholine receptor antibody |
| title | Single-fiber electromyography in the orbicularis oculi muscle in patients with ocular myasthenia gravis symptoms: does abnormal jitter predict response to treatment? |
| title_full | Single-fiber electromyography in the orbicularis oculi muscle in patients with ocular myasthenia gravis symptoms: does abnormal jitter predict response to treatment? |
| title_fullStr | Single-fiber electromyography in the orbicularis oculi muscle in patients with ocular myasthenia gravis symptoms: does abnormal jitter predict response to treatment? |
| title_full_unstemmed | Single-fiber electromyography in the orbicularis oculi muscle in patients with ocular myasthenia gravis symptoms: does abnormal jitter predict response to treatment? |
| title_short | Single-fiber electromyography in the orbicularis oculi muscle in patients with ocular myasthenia gravis symptoms: does abnormal jitter predict response to treatment? |
| title_sort | single fiber electromyography in the orbicularis oculi muscle in patients with ocular myasthenia gravis symptoms does abnormal jitter predict response to treatment |
| topic | Ptosis Diplopia Single-fiber EMG Neuromuscular jitter Acetylcholine receptor antibody |
| url | http://link.springer.com/article/10.1186/s12883-017-0891-5 |
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