<i>Pseudomonas aeruginosa</i> and the Complement System: A Review of the Evasion Strategies
The increasing emergence of multidrug resistant isolates of <i>P. aeruginosa</i> causes major problems in hospitals worldwide. This concern is particularly significant in bloodstream infections that progress rapidly, with a high number of deaths within the first hours and without time to...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/11/3/664 |
| _version_ | 1797610029479624704 |
|---|---|
| author | Alex González-Alsina Margalida Mateu-Borrás Antonio Doménech-Sánchez Sebastián Albertí |
| author_facet | Alex González-Alsina Margalida Mateu-Borrás Antonio Doménech-Sánchez Sebastián Albertí |
| author_sort | Alex González-Alsina |
| collection | DOAJ |
| description | The increasing emergence of multidrug resistant isolates of <i>P. aeruginosa</i> causes major problems in hospitals worldwide. This concern is particularly significant in bloodstream infections that progress rapidly, with a high number of deaths within the first hours and without time to select the most appropriate treatment. In fact, despite improvements in antimicrobial therapy and hospital care, <i>P. aeruginosa</i> bacteremia remains fatal in about 30% of cases. The complement system is a main defensive mechanism in blood against this pathogen. This system can mark bacteria for phagocytosis or directly lyse it via the insertion of a membrane attack complex in the bacterial membrane. <i>P. aeruginosa</i> exploits different strategies to resist complement attack. In this review for the special issue on “bacterial pathogens associated with bacteriemia”, we present an overview of the interactions between <i>P. aeruginosa</i> and the complement components and strategies used by this pathogen to prevent recognition and killing by the complement system. A thorough understanding of these interactions will be critical in order to develop drugs to counteract bacterial evasion mechanisms. |
| first_indexed | 2024-03-11T06:09:44Z |
| format | Article |
| id | doaj.art-d8081cb5e9744308bd566852af4b05ba |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-11T06:09:44Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-d8081cb5e9744308bd566852af4b05ba2023-11-17T12:45:24ZengMDPI AGMicroorganisms2076-26072023-03-0111366410.3390/microorganisms11030664<i>Pseudomonas aeruginosa</i> and the Complement System: A Review of the Evasion StrategiesAlex González-Alsina0Margalida Mateu-Borrás1Antonio Doménech-Sánchez2Sebastián Albertí3Instituto Universitario de Investigación en Ciencias de la Salud, Universidad de las Islas Baleares, 07122 Palma de Mallorca, SpainInstituto Universitario de Investigación en Ciencias de la Salud, Universidad de las Islas Baleares, 07122 Palma de Mallorca, SpainInstituto Universitario de Investigación en Ciencias de la Salud, Universidad de las Islas Baleares, 07122 Palma de Mallorca, SpainInstituto Universitario de Investigación en Ciencias de la Salud, Universidad de las Islas Baleares, 07122 Palma de Mallorca, SpainThe increasing emergence of multidrug resistant isolates of <i>P. aeruginosa</i> causes major problems in hospitals worldwide. This concern is particularly significant in bloodstream infections that progress rapidly, with a high number of deaths within the first hours and without time to select the most appropriate treatment. In fact, despite improvements in antimicrobial therapy and hospital care, <i>P. aeruginosa</i> bacteremia remains fatal in about 30% of cases. The complement system is a main defensive mechanism in blood against this pathogen. This system can mark bacteria for phagocytosis or directly lyse it via the insertion of a membrane attack complex in the bacterial membrane. <i>P. aeruginosa</i> exploits different strategies to resist complement attack. In this review for the special issue on “bacterial pathogens associated with bacteriemia”, we present an overview of the interactions between <i>P. aeruginosa</i> and the complement components and strategies used by this pathogen to prevent recognition and killing by the complement system. A thorough understanding of these interactions will be critical in order to develop drugs to counteract bacterial evasion mechanisms.https://www.mdpi.com/2076-2607/11/3/664complement system<i>Pseudomonas aeruginosa</i>immune evasionbloodstream infection |
| spellingShingle | Alex González-Alsina Margalida Mateu-Borrás Antonio Doménech-Sánchez Sebastián Albertí <i>Pseudomonas aeruginosa</i> and the Complement System: A Review of the Evasion Strategies Microorganisms complement system <i>Pseudomonas aeruginosa</i> immune evasion bloodstream infection |
| title | <i>Pseudomonas aeruginosa</i> and the Complement System: A Review of the Evasion Strategies |
| title_full | <i>Pseudomonas aeruginosa</i> and the Complement System: A Review of the Evasion Strategies |
| title_fullStr | <i>Pseudomonas aeruginosa</i> and the Complement System: A Review of the Evasion Strategies |
| title_full_unstemmed | <i>Pseudomonas aeruginosa</i> and the Complement System: A Review of the Evasion Strategies |
| title_short | <i>Pseudomonas aeruginosa</i> and the Complement System: A Review of the Evasion Strategies |
| title_sort | i pseudomonas aeruginosa i and the complement system a review of the evasion strategies |
| topic | complement system <i>Pseudomonas aeruginosa</i> immune evasion bloodstream infection |
| url | https://www.mdpi.com/2076-2607/11/3/664 |
| work_keys_str_mv | AT alexgonzalezalsina ipseudomonasaeruginosaiandthecomplementsystemareviewoftheevasionstrategies AT margalidamateuborras ipseudomonasaeruginosaiandthecomplementsystemareviewoftheevasionstrategies AT antoniodomenechsanchez ipseudomonasaeruginosaiandthecomplementsystemareviewoftheevasionstrategies AT sebastianalberti ipseudomonasaeruginosaiandthecomplementsystemareviewoftheevasionstrategies |