Clinical laboratory characteristics of severe patients with coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis
Objectives: To identify clinical characteristics of severe patients with COVID-19. Methods: The WHO database of publications on COVID-19 and PubMed were searched from inception to March 20, 2020 and all valuable studies were analyzed using Stata 15.0. Results: We selected forty-four studies with 13,...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
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Elsevier
2021-01-01
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Series: | Clinical Epidemiology and Global Health |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2213398420301950 |
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author | Xiang Li Zhongmou Xu Tianyi Wang Xiang Xu Haiying Li Qin Sun Xinmin Zhou Gang Chen |
author_facet | Xiang Li Zhongmou Xu Tianyi Wang Xiang Xu Haiying Li Qin Sun Xinmin Zhou Gang Chen |
author_sort | Xiang Li |
collection | DOAJ |
description | Objectives: To identify clinical characteristics of severe patients with COVID-19. Methods: The WHO database of publications on COVID-19 and PubMed were searched from inception to March 20, 2020 and all valuable studies were analyzed using Stata 15.0. Results: We selected forty-four studies with 13,497 patients. In the comparison of severe and non-severe groups, age over 50 (OR = 4.090; 95% CI = 2.422–6.907, P = 0.000) and underlying disease (OR = 3.992; 95% CI = 2.631–6.507, P = 0.000) are risk factors. Female gender (OR = 0.740; 95% CI = 0.622–0.881, P = 0.001) is a protective factor. Characteristics like dyspnea (OR = 4.914; 95% CI = 3.069–7.867, P = 0.000), lymphopenia (OR = 5.528; 95% CI = 3.484–8.772, P = 0.000), thrombocytopenia (OR = 3.623; 95% CI = 1.034–12.691, P = 0.044), elevated C-reactive protein (OR = 5.217; 95% CI = 2.459–11.070, P = 0.000) and D-dimer (OR = 3.780; 95% CI = 1.481–9.648, P = 0.005) were more frequently in severe cases. Diffuse lesions and consolidation (OR = 4.680; 95% CI = 3.183–6.881, P = 0.000) in imaging was considered reliable. Conclusions: Men older than 50 with underlying disease are susceptible to develop severe pneumonia while female gender is protective. The typical symptom of severe pneumonia was dyspnea, but high fever, headache and diarrhea were not significantly different among patients with varying degrees of severity. Lymphopenia, thrombocytopenia, elevated C-reactive protein and D-dimer occurred more frequently in severe patients and yet leukopenia is not a characteristic laboratory indicator. Diffuse lesions and consolidation are important imaging features to distinguish severe pneumonia. |
first_indexed | 2024-04-11T19:54:10Z |
format | Article |
id | doaj.art-d8089bc3302843e1850d171cfca103d9 |
institution | Directory Open Access Journal |
issn | 2213-3984 |
language | English |
last_indexed | 2024-04-11T19:54:10Z |
publishDate | 2021-01-01 |
publisher | Elsevier |
record_format | Article |
series | Clinical Epidemiology and Global Health |
spelling | doaj.art-d8089bc3302843e1850d171cfca103d92022-12-22T04:06:12ZengElsevierClinical Epidemiology and Global Health2213-39842021-01-019184190Clinical laboratory characteristics of severe patients with coronavirus disease 2019 (COVID-19): A systematic review and meta-analysisXiang Li0Zhongmou Xu1Tianyi Wang2Xiang Xu3Haiying Li4Qin Sun5Xinmin Zhou6Gang Chen7Department of Clinical Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, ChinaDepartment of Clinical Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, ChinaDepartment of Clinical Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, ChinaDepartment of Clinical Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, ChinaDepartment of Clinical Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, ChinaDepartment of Clinical Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China; Corresponding author.Department of Neurosurgery, The Affiliated Jiangyin Hospital, School of Medicine, Southeast University, Jiangyin, Jiangsu Province, China; Corresponding author.Department of Clinical Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, ChinaObjectives: To identify clinical characteristics of severe patients with COVID-19. Methods: The WHO database of publications on COVID-19 and PubMed were searched from inception to March 20, 2020 and all valuable studies were analyzed using Stata 15.0. Results: We selected forty-four studies with 13,497 patients. In the comparison of severe and non-severe groups, age over 50 (OR = 4.090; 95% CI = 2.422–6.907, P = 0.000) and underlying disease (OR = 3.992; 95% CI = 2.631–6.507, P = 0.000) are risk factors. Female gender (OR = 0.740; 95% CI = 0.622–0.881, P = 0.001) is a protective factor. Characteristics like dyspnea (OR = 4.914; 95% CI = 3.069–7.867, P = 0.000), lymphopenia (OR = 5.528; 95% CI = 3.484–8.772, P = 0.000), thrombocytopenia (OR = 3.623; 95% CI = 1.034–12.691, P = 0.044), elevated C-reactive protein (OR = 5.217; 95% CI = 2.459–11.070, P = 0.000) and D-dimer (OR = 3.780; 95% CI = 1.481–9.648, P = 0.005) were more frequently in severe cases. Diffuse lesions and consolidation (OR = 4.680; 95% CI = 3.183–6.881, P = 0.000) in imaging was considered reliable. Conclusions: Men older than 50 with underlying disease are susceptible to develop severe pneumonia while female gender is protective. The typical symptom of severe pneumonia was dyspnea, but high fever, headache and diarrhea were not significantly different among patients with varying degrees of severity. Lymphopenia, thrombocytopenia, elevated C-reactive protein and D-dimer occurred more frequently in severe patients and yet leukopenia is not a characteristic laboratory indicator. Diffuse lesions and consolidation are important imaging features to distinguish severe pneumonia.http://www.sciencedirect.com/science/article/pii/S2213398420301950SARS-CoV-2Clinical characteristicsDisease severityMeta-analysis |
spellingShingle | Xiang Li Zhongmou Xu Tianyi Wang Xiang Xu Haiying Li Qin Sun Xinmin Zhou Gang Chen Clinical laboratory characteristics of severe patients with coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis Clinical Epidemiology and Global Health SARS-CoV-2 Clinical characteristics Disease severity Meta-analysis |
title | Clinical laboratory characteristics of severe patients with coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis |
title_full | Clinical laboratory characteristics of severe patients with coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis |
title_fullStr | Clinical laboratory characteristics of severe patients with coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis |
title_full_unstemmed | Clinical laboratory characteristics of severe patients with coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis |
title_short | Clinical laboratory characteristics of severe patients with coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis |
title_sort | clinical laboratory characteristics of severe patients with coronavirus disease 2019 covid 19 a systematic review and meta analysis |
topic | SARS-CoV-2 Clinical characteristics Disease severity Meta-analysis |
url | http://www.sciencedirect.com/science/article/pii/S2213398420301950 |
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