Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein Smoothened (Smo), a developmental regulator, oncoprotein and drug target in oncology. We present the 2.3 Å crystal structure of the extracellular cysteine rich domain (CRD) of vertebrate Smo and show that it binds...

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Bibliographic Details
Main Authors: Sigrid Nachtergaele, Daniel M Whalen, Laurel K Mydock, Zhonghua Zhao, Tomas Malinauskas, Kathiresan Krishnan, Philip W Ingham, Douglas F Covey, Christian Siebold, Rajat Rohatgi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-10-01
Series:eLife
Subjects:
Hedgehog signaling
oxysterol
smoothened
cysteine rich domain
Online Access:https://elifesciences.org/articles/01340

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