Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet
Maternal microbiota forms the first infant gut microbial inoculum, and perinatal factors (diet and use of antibiotics during pregnancy) and/or neonatal factors, like intra partum antibiotics, gestational age and mode of delivery, may influence microbial colonization. After birth, when the principal...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1236254/full |
| _version_ | 1827862556602007552 |
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| author | Clara Suárez-Martínez Clara Suárez-Martínez Marina Santaella-Pascual Marina Santaella-Pascual Genoveva Yagüe-Guirao Genoveva Yagüe-Guirao Carmen Martínez-Graciá Carmen Martínez-Graciá |
| author_facet | Clara Suárez-Martínez Clara Suárez-Martínez Marina Santaella-Pascual Marina Santaella-Pascual Genoveva Yagüe-Guirao Genoveva Yagüe-Guirao Carmen Martínez-Graciá Carmen Martínez-Graciá |
| author_sort | Clara Suárez-Martínez |
| collection | DOAJ |
| description | Maternal microbiota forms the first infant gut microbial inoculum, and perinatal factors (diet and use of antibiotics during pregnancy) and/or neonatal factors, like intra partum antibiotics, gestational age and mode of delivery, may influence microbial colonization. After birth, when the principal colonization occurs, the microbial diversity increases and converges toward a stable adult-like microbiota by the end of the first 3–5 years of life. However, during the early life, gut microbiota can be disrupted by other postnatal factors like mode of infant feeding, antibiotic usage, and various environmental factors generating a state of dysbiosis. Gut dysbiosis have been reported to increase the risk of necrotizing enterocolitis and some chronic diseases later in life, such as obesity, diabetes, cancer, allergies, and asthma. Therefore, understanding the impact of a correct maternal-to-infant microbial transfer and a good infant early colonization and maturation throughout life would reduce the risk of disease in early and late life. This paper reviews the published evidence on early-life gut microbiota development, as well as the different factors influencing its evolution before, at, and after birth, focusing on diet and nutrition during pregnancy and in the first months of life. |
| first_indexed | 2024-03-12T13:57:15Z |
| format | Article |
| id | doaj.art-d809094904cd4a9eacc297e26c8fcc44 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-12T13:57:15Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-d809094904cd4a9eacc297e26c8fcc442023-08-22T12:42:46ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-08-011410.3389/fmicb.2023.12362541236254Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on dietClara Suárez-Martínez0Clara Suárez-Martínez1Marina Santaella-Pascual2Marina Santaella-Pascual3Genoveva Yagüe-Guirao4Genoveva Yagüe-Guirao5Carmen Martínez-Graciá6Carmen Martínez-Graciá7Food Science and Nutrition Department, Veterinary Faculty, Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, Murcia, SpainBiomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, SpainFood Science and Nutrition Department, Veterinary Faculty, Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, Murcia, SpainBiomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, SpainFood Science and Nutrition Department, Veterinary Faculty, Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, Murcia, SpainMicrobiology Service, Virgen de La Arrixaca University Hospital, Murcia, SpainFood Science and Nutrition Department, Veterinary Faculty, Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, Murcia, SpainBiomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, SpainMaternal microbiota forms the first infant gut microbial inoculum, and perinatal factors (diet and use of antibiotics during pregnancy) and/or neonatal factors, like intra partum antibiotics, gestational age and mode of delivery, may influence microbial colonization. After birth, when the principal colonization occurs, the microbial diversity increases and converges toward a stable adult-like microbiota by the end of the first 3–5 years of life. However, during the early life, gut microbiota can be disrupted by other postnatal factors like mode of infant feeding, antibiotic usage, and various environmental factors generating a state of dysbiosis. Gut dysbiosis have been reported to increase the risk of necrotizing enterocolitis and some chronic diseases later in life, such as obesity, diabetes, cancer, allergies, and asthma. Therefore, understanding the impact of a correct maternal-to-infant microbial transfer and a good infant early colonization and maturation throughout life would reduce the risk of disease in early and late life. This paper reviews the published evidence on early-life gut microbiota development, as well as the different factors influencing its evolution before, at, and after birth, focusing on diet and nutrition during pregnancy and in the first months of life.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1236254/fullgut microbiotabreast-feedingdietdelivery modecolonizationpregnancy |
| spellingShingle | Clara Suárez-Martínez Clara Suárez-Martínez Marina Santaella-Pascual Marina Santaella-Pascual Genoveva Yagüe-Guirao Genoveva Yagüe-Guirao Carmen Martínez-Graciá Carmen Martínez-Graciá Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet Frontiers in Microbiology gut microbiota breast-feeding diet delivery mode colonization pregnancy |
| title | Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet |
| title_full | Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet |
| title_fullStr | Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet |
| title_full_unstemmed | Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet |
| title_short | Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet |
| title_sort | infant gut microbiota colonization influence of prenatal and postnatal factors focusing on diet |
| topic | gut microbiota breast-feeding diet delivery mode colonization pregnancy |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1236254/full |
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