Bifidobacteria shape antimicrobial T-helper cell responses during infancy and adulthood
Abstract Microbial infections early in life are challenging for the unexperienced immune system. The SARS-CoV-2 pandemic again has highlighted that neonatal, infant, child, and adult T-helper(Th)-cells respond differently to infections, and requires further understanding. This study investigates ant...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-41630-x |
| _version_ | 1797558547946405888 |
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| author | Katrin Vogel Aditya Arra Holger Lingel Dirk Bretschneider Florian Prätsch Denny Schanze Martin Zenker Silke Balk Dunja Bruder Robert Geffers Thomas Hachenberg Christoph Arens Monika C. Brunner-Weinzierl |
| author_facet | Katrin Vogel Aditya Arra Holger Lingel Dirk Bretschneider Florian Prätsch Denny Schanze Martin Zenker Silke Balk Dunja Bruder Robert Geffers Thomas Hachenberg Christoph Arens Monika C. Brunner-Weinzierl |
| author_sort | Katrin Vogel |
| collection | DOAJ |
| description | Abstract Microbial infections early in life are challenging for the unexperienced immune system. The SARS-CoV-2 pandemic again has highlighted that neonatal, infant, child, and adult T-helper(Th)-cells respond differently to infections, and requires further understanding. This study investigates anti-bacterial T-cell responses against Staphylococcus aureus aureus, Staphylococcus epidermidis and Bifidobacterium longum infantis in early stages of life and adults and shows age and pathogen-dependent mechanisms. Beside activation-induced clustering, T-cells stimulated with Staphylococci become Th1-type cells; however, this differentiation is mitigated in Bifidobacterium-stimulated T-cells. Strikingly, prestimulation of T-cells with Bifidobacterium suppresses the activation of Staphylococcus-specific T-helper cells in a cell-cell dependent manner by inducing FoxP3+CD4+ T-cells, increasing IL-10 and galectin-1 secretion and showing a CTLA-4-dependent inhibitory capacity. Furthermore Bifidobacterium dampens Th responses of severely ill COVID-19 patients likely contributing to resolution of harmful overreactions of the immune system. Targeted, age-specific interventions may enhance infection defence, and specific immune features may have potential cross-age utilization. |
| first_indexed | 2024-03-10T17:33:00Z |
| format | Article |
| id | doaj.art-d80b20045d7949eebfdb45342967d917 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:33:00Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d80b20045d7949eebfdb45342967d9172023-11-20T09:58:32ZengNature PortfolioNature Communications2041-17232023-09-0114111310.1038/s41467-023-41630-xBifidobacteria shape antimicrobial T-helper cell responses during infancy and adulthoodKatrin Vogel0Aditya Arra1Holger Lingel2Dirk Bretschneider3Florian Prätsch4Denny Schanze5Martin Zenker6Silke Balk7Dunja Bruder8Robert Geffers9Thomas Hachenberg10Christoph Arens11Monika C. Brunner-Weinzierl12Department of Experimental Paediatrics, University Hospital, Otto-von-Guericke UniversityDepartment of Experimental Paediatrics, University Hospital, Otto-von-Guericke UniversityDepartment of Experimental Paediatrics, University Hospital, Otto-von-Guericke UniversityDepartment of Paediatrics, Hospital St MarienstiftDepartment of Anaesthesiology and Intensive Care Medicine, University Hospital, Otto-von-Guericke-UniversityInstitute of Human Genetics, University Hospital, Otto-von-Guericke UniversityInstitute of Human Genetics, University Hospital, Otto-von-Guericke UniversityDepartment of Experimental Paediatrics, University Hospital, Otto-von-Guericke UniversityInfection Immunology Group, Institute of Medical Microbiology and Hospital Hygiene, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke UniversityGenome Analytics, Helmholtz Centre for Infection ResearchDepartment of Anaesthesiology and Intensive Care Medicine, University Hospital, Otto-von-Guericke-UniversityDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Otto-von-Guericke UniversityDepartment of Experimental Paediatrics, University Hospital, Otto-von-Guericke UniversityAbstract Microbial infections early in life are challenging for the unexperienced immune system. The SARS-CoV-2 pandemic again has highlighted that neonatal, infant, child, and adult T-helper(Th)-cells respond differently to infections, and requires further understanding. This study investigates anti-bacterial T-cell responses against Staphylococcus aureus aureus, Staphylococcus epidermidis and Bifidobacterium longum infantis in early stages of life and adults and shows age and pathogen-dependent mechanisms. Beside activation-induced clustering, T-cells stimulated with Staphylococci become Th1-type cells; however, this differentiation is mitigated in Bifidobacterium-stimulated T-cells. Strikingly, prestimulation of T-cells with Bifidobacterium suppresses the activation of Staphylococcus-specific T-helper cells in a cell-cell dependent manner by inducing FoxP3+CD4+ T-cells, increasing IL-10 and galectin-1 secretion and showing a CTLA-4-dependent inhibitory capacity. Furthermore Bifidobacterium dampens Th responses of severely ill COVID-19 patients likely contributing to resolution of harmful overreactions of the immune system. Targeted, age-specific interventions may enhance infection defence, and specific immune features may have potential cross-age utilization.https://doi.org/10.1038/s41467-023-41630-x |
| spellingShingle | Katrin Vogel Aditya Arra Holger Lingel Dirk Bretschneider Florian Prätsch Denny Schanze Martin Zenker Silke Balk Dunja Bruder Robert Geffers Thomas Hachenberg Christoph Arens Monika C. Brunner-Weinzierl Bifidobacteria shape antimicrobial T-helper cell responses during infancy and adulthood Nature Communications |
| title | Bifidobacteria shape antimicrobial T-helper cell responses during infancy and adulthood |
| title_full | Bifidobacteria shape antimicrobial T-helper cell responses during infancy and adulthood |
| title_fullStr | Bifidobacteria shape antimicrobial T-helper cell responses during infancy and adulthood |
| title_full_unstemmed | Bifidobacteria shape antimicrobial T-helper cell responses during infancy and adulthood |
| title_short | Bifidobacteria shape antimicrobial T-helper cell responses during infancy and adulthood |
| title_sort | bifidobacteria shape antimicrobial t helper cell responses during infancy and adulthood |
| url | https://doi.org/10.1038/s41467-023-41630-x |
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