Reticulation pattern without honeycombing on high-resolution CT is associated with the risk of disease progression in interstitial lung diseases
Abstract Background The disease course of idiopathic pulmonary fibrosis (IPF) is progressive and occasionally, other types of interstitial lung disease (ILD) may progress similarly to IPF. This study aimed to evaluate risk factors for disease progression within 24 months in patients with various ILD...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12890-022-02105-9 |
| _version_ | 1798042486038331392 |
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| author | Minna Mononen Eeva Saari Hannele Hasala Hannu-Pekka Kettunen Sanna Suoranta Hanna Nurmi Miia Kärkkäinen Tuomas Selander Jukka Randell Jari Laurikka Toomas Uibu Heikki Koskela Riitta Kaarteenaho Minna Purokivi |
| author_facet | Minna Mononen Eeva Saari Hannele Hasala Hannu-Pekka Kettunen Sanna Suoranta Hanna Nurmi Miia Kärkkäinen Tuomas Selander Jukka Randell Jari Laurikka Toomas Uibu Heikki Koskela Riitta Kaarteenaho Minna Purokivi |
| author_sort | Minna Mononen |
| collection | DOAJ |
| description | Abstract Background The disease course of idiopathic pulmonary fibrosis (IPF) is progressive and occasionally, other types of interstitial lung disease (ILD) may progress similarly to IPF. This study aimed to evaluate risk factors for disease progression within 24 months in patients with various ILDs. Methods This prospective study obtained 97 patients with a suspected ILD who underwent a transbronchial lung cryobiopsy. The extent of several high-resolution computed tomography (HRCT) patterns was assessed. Due to the inclusion criteria the study population presented a low extent of honeycombing and definite usual interstitial pneumonia (UIP) pattern on HRCT suggesting an early stage of ILD. Disease progression within 24 months despite treatment was defined as a relative decline of ≥ 10% in forced vital capacity (FVC), or a relative decline in FVC of ≥ 5% and one of the three additional criteria: (1) a decline in diffusion capacity to carbon monoxide (DLCO) ≥ 15%; (2) increased fibrosis on HRCT; (3) progressive symptoms, or progressive symptoms and increased fibrosis on HRCT. The same definition was utilized in patients with IPF and other ILDs. Risk factors for disease progression were evaluated in a multivariable logistic regression model. Results Disease progression was revealed in 52% of the patients with ILD, 51% of the patients with IPF, and 53% of the patients with other types of ILD. A high extent of reticulation on HRCT (Odds ratio [OR] 3.11, 95% Confidence interval [CI] 1.21–7.98, P = 0.019) and never smoking (OR 3.11, CI 1.12–8.63, P = 0.029) were associated with disease progression whereas platelet count (OR 2.06 per 100 units increase, CI 0.96–4.45, P = 0.065) did not quite reach statistical significance. Conclusion Higher extent of reticulation on HRCT and never smoking appeared to associate with the risk of disease progression within 24 months in ILD patients without honeycombing. Approximately half of the patients with ILD revealed disease progression, and similar proportions were observed in patients with IPF and in other types of ILD. |
| first_indexed | 2024-04-11T22:36:11Z |
| format | Article |
| id | doaj.art-d80b85f2ee114835bcb245f6a4ffa644 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-11T22:36:11Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-d80b85f2ee114835bcb245f6a4ffa6442022-12-22T03:59:13ZengBMCBMC Pulmonary Medicine1471-24662022-08-0122111110.1186/s12890-022-02105-9Reticulation pattern without honeycombing on high-resolution CT is associated with the risk of disease progression in interstitial lung diseasesMinna Mononen0Eeva Saari1Hannele Hasala2Hannu-Pekka Kettunen3Sanna Suoranta4Hanna Nurmi5Miia Kärkkäinen6Tuomas Selander7Jukka Randell8Jari Laurikka9Toomas Uibu10Heikki Koskela11Riitta Kaarteenaho12Minna Purokivi13Division of Respiratory Medicine, Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern FinlandDivision of Respiratory Medicine, Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern FinlandDepartment of Respiratory Medicine, Tampere University HospitalDepartment of Clinical Radiology, Kuopio University HospitalDepartment of Clinical Radiology, Kuopio University HospitalDivision of Respiratory Medicine, Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern FinlandAcute Services, Kuopio University HospitalScience Services Center, Kuopio University HospitalCenter of Medicine and Clinical Research, Division of Respiratory Medicine, Kuopio University HospitalTampere University Heart Hospital and Finnish Cardiovascular Research Center, Tampere UniversityDepartment of Respiratory Medicine, Tampere University HospitalDivision of Respiratory Medicine, Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern FinlandResearch Unit of Internal Medicine, University of OuluCenter of Medicine and Clinical Research, Division of Respiratory Medicine, Kuopio University HospitalAbstract Background The disease course of idiopathic pulmonary fibrosis (IPF) is progressive and occasionally, other types of interstitial lung disease (ILD) may progress similarly to IPF. This study aimed to evaluate risk factors for disease progression within 24 months in patients with various ILDs. Methods This prospective study obtained 97 patients with a suspected ILD who underwent a transbronchial lung cryobiopsy. The extent of several high-resolution computed tomography (HRCT) patterns was assessed. Due to the inclusion criteria the study population presented a low extent of honeycombing and definite usual interstitial pneumonia (UIP) pattern on HRCT suggesting an early stage of ILD. Disease progression within 24 months despite treatment was defined as a relative decline of ≥ 10% in forced vital capacity (FVC), or a relative decline in FVC of ≥ 5% and one of the three additional criteria: (1) a decline in diffusion capacity to carbon monoxide (DLCO) ≥ 15%; (2) increased fibrosis on HRCT; (3) progressive symptoms, or progressive symptoms and increased fibrosis on HRCT. The same definition was utilized in patients with IPF and other ILDs. Risk factors for disease progression were evaluated in a multivariable logistic regression model. Results Disease progression was revealed in 52% of the patients with ILD, 51% of the patients with IPF, and 53% of the patients with other types of ILD. A high extent of reticulation on HRCT (Odds ratio [OR] 3.11, 95% Confidence interval [CI] 1.21–7.98, P = 0.019) and never smoking (OR 3.11, CI 1.12–8.63, P = 0.029) were associated with disease progression whereas platelet count (OR 2.06 per 100 units increase, CI 0.96–4.45, P = 0.065) did not quite reach statistical significance. Conclusion Higher extent of reticulation on HRCT and never smoking appeared to associate with the risk of disease progression within 24 months in ILD patients without honeycombing. Approximately half of the patients with ILD revealed disease progression, and similar proportions were observed in patients with IPF and in other types of ILD.https://doi.org/10.1186/s12890-022-02105-9Disease progressionInterstitial lung disease (ILD)Idiopathic pulmonary fibrosis (IPF)Radiology |
| spellingShingle | Minna Mononen Eeva Saari Hannele Hasala Hannu-Pekka Kettunen Sanna Suoranta Hanna Nurmi Miia Kärkkäinen Tuomas Selander Jukka Randell Jari Laurikka Toomas Uibu Heikki Koskela Riitta Kaarteenaho Minna Purokivi Reticulation pattern without honeycombing on high-resolution CT is associated with the risk of disease progression in interstitial lung diseases BMC Pulmonary Medicine Disease progression Interstitial lung disease (ILD) Idiopathic pulmonary fibrosis (IPF) Radiology |
| title | Reticulation pattern without honeycombing on high-resolution CT is associated with the risk of disease progression in interstitial lung diseases |
| title_full | Reticulation pattern without honeycombing on high-resolution CT is associated with the risk of disease progression in interstitial lung diseases |
| title_fullStr | Reticulation pattern without honeycombing on high-resolution CT is associated with the risk of disease progression in interstitial lung diseases |
| title_full_unstemmed | Reticulation pattern without honeycombing on high-resolution CT is associated with the risk of disease progression in interstitial lung diseases |
| title_short | Reticulation pattern without honeycombing on high-resolution CT is associated with the risk of disease progression in interstitial lung diseases |
| title_sort | reticulation pattern without honeycombing on high resolution ct is associated with the risk of disease progression in interstitial lung diseases |
| topic | Disease progression Interstitial lung disease (ILD) Idiopathic pulmonary fibrosis (IPF) Radiology |
| url | https://doi.org/10.1186/s12890-022-02105-9 |
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