Anti-Wrinkle Effect of BB-1000: A Double-Blind, Randomized Controlled Study
Skin aging usually results from intrinsic or extrinsic stress. Photodamage promotes skin damage and stimulates the skin, manifesting as wrinkles, dryness, roughness, and loss of elasticity. We have previously found that blackberry (<i>Rubus fruticosus</i> B) fermented by <i>Lactoba...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Cosmetics |
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| Online Access: | https://www.mdpi.com/2079-9284/9/3/50 |
| _version_ | 1797488611260628992 |
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| author | Sang-Wang Lee Hong-Sig Sin Joon Hurh Seon-Young Kim |
| author_facet | Sang-Wang Lee Hong-Sig Sin Joon Hurh Seon-Young Kim |
| author_sort | Sang-Wang Lee |
| collection | DOAJ |
| description | Skin aging usually results from intrinsic or extrinsic stress. Photodamage promotes skin damage and stimulates the skin, manifesting as wrinkles, dryness, roughness, and loss of elasticity. We have previously found that blackberry (<i>Rubus fruticosus</i> B) fermented by <i>Lactobacillus plantarum</i> JBMI F5, designated BB-1000, showed an in vitro and in vivo anti-skin-aging activity. In the present study, we have further evaluated the anti-aging effect of BB-1000 via a randomized, double-blind, and placebo-controlled clinical trial. The trial included 102 volunteers aged 35 to 59 years who have dry skin and wrinkles. Subjects took BB-1000 or a placebo orally at 800 mg/day for 12 weeks. Skin hydration and degree of wrinkles around the eyes were measured at weeks 6 and 12. Skin hydration had no significant effect in both groups at weeks 6 and 12. Otherwise, volunteers in the BB-1000 group had a significant reduction in eye wrinkle grade at week 12. These findings suggest that BB-1000 may be considered a candidate anti-aging agent for preventing skin wrinkles as a nutricosmetic agent. |
| first_indexed | 2024-03-10T00:04:44Z |
| format | Article |
| id | doaj.art-d80c14ec81c148e98bdbbe1410b6146f |
| institution | Directory Open Access Journal |
| issn | 2079-9284 |
| language | English |
| last_indexed | 2024-03-10T00:04:44Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj.art-d80c14ec81c148e98bdbbe1410b6146f2023-11-23T16:10:40ZengMDPI AGCosmetics2079-92842022-05-01935010.3390/cosmetics9030050Anti-Wrinkle Effect of BB-1000: A Double-Blind, Randomized Controlled StudySang-Wang Lee0Hong-Sig Sin1Joon Hurh2Seon-Young Kim3Chebigen Co. Ltd., Jeonju 54853, KoreaChebigen Co. Ltd., Jeonju 54853, KoreaChebigen Co. Ltd., Jeonju 54853, KoreaJeonju AgroBio-Materials Institute, Wonjangdong-gil 111-27, Jeonju 54810, KoreaSkin aging usually results from intrinsic or extrinsic stress. Photodamage promotes skin damage and stimulates the skin, manifesting as wrinkles, dryness, roughness, and loss of elasticity. We have previously found that blackberry (<i>Rubus fruticosus</i> B) fermented by <i>Lactobacillus plantarum</i> JBMI F5, designated BB-1000, showed an in vitro and in vivo anti-skin-aging activity. In the present study, we have further evaluated the anti-aging effect of BB-1000 via a randomized, double-blind, and placebo-controlled clinical trial. The trial included 102 volunteers aged 35 to 59 years who have dry skin and wrinkles. Subjects took BB-1000 or a placebo orally at 800 mg/day for 12 weeks. Skin hydration and degree of wrinkles around the eyes were measured at weeks 6 and 12. Skin hydration had no significant effect in both groups at weeks 6 and 12. Otherwise, volunteers in the BB-1000 group had a significant reduction in eye wrinkle grade at week 12. These findings suggest that BB-1000 may be considered a candidate anti-aging agent for preventing skin wrinkles as a nutricosmetic agent.https://www.mdpi.com/2079-9284/9/3/50skin agingclinical studyrandomizeddouble-blindprobiotics |
| spellingShingle | Sang-Wang Lee Hong-Sig Sin Joon Hurh Seon-Young Kim Anti-Wrinkle Effect of BB-1000: A Double-Blind, Randomized Controlled Study Cosmetics skin aging clinical study randomized double-blind probiotics |
| title | Anti-Wrinkle Effect of BB-1000: A Double-Blind, Randomized Controlled Study |
| title_full | Anti-Wrinkle Effect of BB-1000: A Double-Blind, Randomized Controlled Study |
| title_fullStr | Anti-Wrinkle Effect of BB-1000: A Double-Blind, Randomized Controlled Study |
| title_full_unstemmed | Anti-Wrinkle Effect of BB-1000: A Double-Blind, Randomized Controlled Study |
| title_short | Anti-Wrinkle Effect of BB-1000: A Double-Blind, Randomized Controlled Study |
| title_sort | anti wrinkle effect of bb 1000 a double blind randomized controlled study |
| topic | skin aging clinical study randomized double-blind probiotics |
| url | https://www.mdpi.com/2079-9284/9/3/50 |
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