Increasing seroprevalence of Japanese encephalitis virus in even-toed hoofed mammals (Artiodactyla species) associated with an upsurge of human cases in South Korea
ABSTRACT: Objectives: The annual incidence of Japanese encephalitis (JE) has increased markedly in South Korea since 2010. We hypothesized that this increase was associated with higher frequencies of JE virus in animals. Methods: We analyzed 5201 serum samples collected from even-toed hoofed mammal...
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| Format: | Article |
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Elsevier
2023-05-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971223000024 |
| _version_ | 1797850533271175168 |
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| author | Sangshin Park Yun Young Go Ian C. Michelow Jung-Yong Yeh |
| author_facet | Sangshin Park Yun Young Go Ian C. Michelow Jung-Yong Yeh |
| author_sort | Sangshin Park |
| collection | DOAJ |
| description | ABSTRACT: Objectives: The annual incidence of Japanese encephalitis (JE) has increased markedly in South Korea since 2010. We hypothesized that this increase was associated with higher frequencies of JE virus in animals. Methods: We analyzed 5201 serum samples collected from even-toed hoofed mammals (Artiodactyla species) across South Korea from 2008 to 2012 using a stratified two-stage probability approach. Results: The highest annual incidence of human JE cases and deaths occurred in 2010. Cases increased from six (no deaths) in 2008-2009 to 26 cases (seven deaths) in 2010. The JE virus seroprevalence in deer and elk fawns increased from 2.4% in 2008 to 24.1% in 2009, and in wild boars, it increased from 19.3% to 55.0% in the same period, which preceded the surge of human cases. Furthermore, the seroprevalence in calves increased from 15.3% in 2008 to 35.8% in 2010, and that in lambs and goat kids, increased from 8.5% in 2009 to 26.2% in 2010, which coincided with the surge in humans. Conclusion: Our findings show that the increased incidence of human JE in South Korea was temporally associated with an increasing seroprevalence in the Artiodactyla species. Surveillance of sentinel animals may be useful to predict the emergence of JE in humans. |
| first_indexed | 2024-04-09T19:01:34Z |
| format | Article |
| id | doaj.art-d80cafe32d9047acb363183a34a8e5d5 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-09T19:01:34Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-d80cafe32d9047acb363183a34a8e5d52023-04-08T05:10:38ZengElsevierInternational Journal of Infectious Diseases1201-97122023-05-01130101107Increasing seroprevalence of Japanese encephalitis virus in even-toed hoofed mammals (Artiodactyla species) associated with an upsurge of human cases in South KoreaSangshin Park0Yun Young Go1Ian C. Michelow2Jung-Yong Yeh3Graduate School of Urban Public Health & Department of Urban Big Data Convergence, University of Seoul, Seoul, South Korea; Department of Pathology and Laboratory Medicine, Brown University Medical School, Providence, USADepartment of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine, City University of Hong Kong, Hong Kong SAR, ChinaDepartment of Pediatrics, Division of Infectious Diseases and Immunology, Connecticut Children's Medical Center, Hartford, USA; Department of Pediatrics, University of Connecticut School of Medicine, Farmington, USADepartment of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, South Korea; Research Institute for New Drug Development, Incheon National University, Incheon, South Korea; Convergence Research Center for Insect Vectors, Incheon National University, Incheon, South Korea; KU Center for Animal Blood Medical Science, College of Veterinary Medicine, Konkuk University, Seoul, South Korea; Corresponding author.ABSTRACT: Objectives: The annual incidence of Japanese encephalitis (JE) has increased markedly in South Korea since 2010. We hypothesized that this increase was associated with higher frequencies of JE virus in animals. Methods: We analyzed 5201 serum samples collected from even-toed hoofed mammals (Artiodactyla species) across South Korea from 2008 to 2012 using a stratified two-stage probability approach. Results: The highest annual incidence of human JE cases and deaths occurred in 2010. Cases increased from six (no deaths) in 2008-2009 to 26 cases (seven deaths) in 2010. The JE virus seroprevalence in deer and elk fawns increased from 2.4% in 2008 to 24.1% in 2009, and in wild boars, it increased from 19.3% to 55.0% in the same period, which preceded the surge of human cases. Furthermore, the seroprevalence in calves increased from 15.3% in 2008 to 35.8% in 2010, and that in lambs and goat kids, increased from 8.5% in 2009 to 26.2% in 2010, which coincided with the surge in humans. Conclusion: Our findings show that the increased incidence of human JE in South Korea was temporally associated with an increasing seroprevalence in the Artiodactyla species. Surveillance of sentinel animals may be useful to predict the emergence of JE in humans.http://www.sciencedirect.com/science/article/pii/S1201971223000024ArtiodactylaEven-toed hoofed mammalJapanese encephalitis virusEmerging infectious diseaseOne HealthSouth Korea |
| spellingShingle | Sangshin Park Yun Young Go Ian C. Michelow Jung-Yong Yeh Increasing seroprevalence of Japanese encephalitis virus in even-toed hoofed mammals (Artiodactyla species) associated with an upsurge of human cases in South Korea International Journal of Infectious Diseases Artiodactyla Even-toed hoofed mammal Japanese encephalitis virus Emerging infectious disease One Health South Korea |
| title | Increasing seroprevalence of Japanese encephalitis virus in even-toed hoofed mammals (Artiodactyla species) associated with an upsurge of human cases in South Korea |
| title_full | Increasing seroprevalence of Japanese encephalitis virus in even-toed hoofed mammals (Artiodactyla species) associated with an upsurge of human cases in South Korea |
| title_fullStr | Increasing seroprevalence of Japanese encephalitis virus in even-toed hoofed mammals (Artiodactyla species) associated with an upsurge of human cases in South Korea |
| title_full_unstemmed | Increasing seroprevalence of Japanese encephalitis virus in even-toed hoofed mammals (Artiodactyla species) associated with an upsurge of human cases in South Korea |
| title_short | Increasing seroprevalence of Japanese encephalitis virus in even-toed hoofed mammals (Artiodactyla species) associated with an upsurge of human cases in South Korea |
| title_sort | increasing seroprevalence of japanese encephalitis virus in even toed hoofed mammals artiodactyla species associated with an upsurge of human cases in south korea |
| topic | Artiodactyla Even-toed hoofed mammal Japanese encephalitis virus Emerging infectious disease One Health South Korea |
| url | http://www.sciencedirect.com/science/article/pii/S1201971223000024 |
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