Evaluation of hard capsule application from seaweed: Gum Arabic-Kappa carrageenan biocomposite films
At present, plant-based hard capsule such as hydroxypropyl methylcellulose (HPMC) has a high demand in drug delivery application but the production process is expensive with limited reactant supply. κ-carrageenan has been used as a gelling agent in HPMC hard capsule production. This study aims to de...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Cogent Engineering |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23311916.2020.1765682 |
| _version_ | 1797724216977522688 |
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| author | Fatmawati Adam Jurida Jamaludin Siti Hana Abu Bakar Ruwaida Abdul Rasid Zulkafli Hassan |
| author_facet | Fatmawati Adam Jurida Jamaludin Siti Hana Abu Bakar Ruwaida Abdul Rasid Zulkafli Hassan |
| author_sort | Fatmawati Adam |
| collection | DOAJ |
| description | At present, plant-based hard capsule such as hydroxypropyl methylcellulose (HPMC) has a high demand in drug delivery application but the production process is expensive with limited reactant supply. κ-carrageenan has been used as a gelling agent in HPMC hard capsule production. This study aims to develop gum Arabic (GA)-κ-carrageenan biocomposite, a potential material to produce hard capsule. The GA-κ-carrageenan biocomposite films were prepared at different κ-carrageenan weight ratios of 33% (GC33), 50% (GC50) and 67% (GC67) at constant concentration of polyethylene glycol and alginate. The control films of GA film and κ-carrageenan film were compared. The film and hard capsule formed from GC67 shows the highest tensile strength and capsule loop of 36.21 MPa and 34.11 N, respectively at 1058 mPa.s solution viscosity at 300 rpm shear rate. The hard capsule disintegrated at 7.30 min. The addition of GA is compatible to make the hard capsule surface smoother. Thus, this biocomposite has the potential to be developed for future hard capsule. |
| first_indexed | 2024-03-12T10:14:15Z |
| format | Article |
| id | doaj.art-d80f150b1bfd44998ba420b922dcc9ec |
| institution | Directory Open Access Journal |
| issn | 2331-1916 |
| language | English |
| last_indexed | 2024-03-12T10:14:15Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cogent Engineering |
| spelling | doaj.art-d80f150b1bfd44998ba420b922dcc9ec2023-09-02T10:39:30ZengTaylor & Francis GroupCogent Engineering2331-19162020-01-017110.1080/23311916.2020.17656821765682Evaluation of hard capsule application from seaweed: Gum Arabic-Kappa carrageenan biocomposite filmsFatmawati Adam0Jurida Jamaludin1Siti Hana Abu Bakar2Ruwaida Abdul Rasid3Zulkafli Hassan4University Malaysia PahangUniversity Malaysia PahangUniversity Malaysia PahangUniversity Malaysia PahangUniversity Malaysia PahangAt present, plant-based hard capsule such as hydroxypropyl methylcellulose (HPMC) has a high demand in drug delivery application but the production process is expensive with limited reactant supply. κ-carrageenan has been used as a gelling agent in HPMC hard capsule production. This study aims to develop gum Arabic (GA)-κ-carrageenan biocomposite, a potential material to produce hard capsule. The GA-κ-carrageenan biocomposite films were prepared at different κ-carrageenan weight ratios of 33% (GC33), 50% (GC50) and 67% (GC67) at constant concentration of polyethylene glycol and alginate. The control films of GA film and κ-carrageenan film were compared. The film and hard capsule formed from GC67 shows the highest tensile strength and capsule loop of 36.21 MPa and 34.11 N, respectively at 1058 mPa.s solution viscosity at 300 rpm shear rate. The hard capsule disintegrated at 7.30 min. The addition of GA is compatible to make the hard capsule surface smoother. Thus, this biocomposite has the potential to be developed for future hard capsule.http://dx.doi.org/10.1080/23311916.2020.1765682seaweedthermal stabilitytensile strengthviscositydisintegration time |
| spellingShingle | Fatmawati Adam Jurida Jamaludin Siti Hana Abu Bakar Ruwaida Abdul Rasid Zulkafli Hassan Evaluation of hard capsule application from seaweed: Gum Arabic-Kappa carrageenan biocomposite films Cogent Engineering seaweed thermal stability tensile strength viscosity disintegration time |
| title | Evaluation of hard capsule application from seaweed: Gum Arabic-Kappa carrageenan biocomposite films |
| title_full | Evaluation of hard capsule application from seaweed: Gum Arabic-Kappa carrageenan biocomposite films |
| title_fullStr | Evaluation of hard capsule application from seaweed: Gum Arabic-Kappa carrageenan biocomposite films |
| title_full_unstemmed | Evaluation of hard capsule application from seaweed: Gum Arabic-Kappa carrageenan biocomposite films |
| title_short | Evaluation of hard capsule application from seaweed: Gum Arabic-Kappa carrageenan biocomposite films |
| title_sort | evaluation of hard capsule application from seaweed gum arabic kappa carrageenan biocomposite films |
| topic | seaweed thermal stability tensile strength viscosity disintegration time |
| url | http://dx.doi.org/10.1080/23311916.2020.1765682 |
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