Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis
Amyloid fibrils of β2-microglobulin (β2m) can cause dialysis-related amyloidosis. Here, the authors show that a decrease in serum albumin levels in long-term dialysis deteriorates the inhibitory effects of serum milieux on supersaturation-limited amyloid formation of β2m, suggesting that macromolecu...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33247-3 |
| _version_ | 1828106098515640320 |
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| author | Kichitaro Nakajima Keiichi Yamaguchi Masahiro Noji César Aguirre Kensuke Ikenaka Hideki Mochizuki Lianjie Zhou Hirotsugu Ogi Toru Ito Ichiei Narita Fumitake Gejyo Hironobu Naiki Suguru Yamamoto Yuji Goto |
| author_facet | Kichitaro Nakajima Keiichi Yamaguchi Masahiro Noji César Aguirre Kensuke Ikenaka Hideki Mochizuki Lianjie Zhou Hirotsugu Ogi Toru Ito Ichiei Narita Fumitake Gejyo Hironobu Naiki Suguru Yamamoto Yuji Goto |
| author_sort | Kichitaro Nakajima |
| collection | DOAJ |
| description | Amyloid fibrils of β2-microglobulin (β2m) can cause dialysis-related amyloidosis. Here, the authors show that a decrease in serum albumin levels in long-term dialysis deteriorates the inhibitory effects of serum milieux on supersaturation-limited amyloid formation of β2m, suggesting that macromolecular crowding protects the onset of amyloidosis. |
| first_indexed | 2024-04-11T10:12:14Z |
| format | Article |
| id | doaj.art-d80ffdffa03b47a68ce0fdd216dda884 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T10:12:14Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d80ffdffa03b47a68ce0fdd216dda8842022-12-22T04:30:04ZengNature PortfolioNature Communications2041-17232022-10-0113111310.1038/s41467-022-33247-3Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosisKichitaro Nakajima0Keiichi Yamaguchi1Masahiro Noji2César Aguirre3Kensuke Ikenaka4Hideki Mochizuki5Lianjie Zhou6Hirotsugu Ogi7Toru Ito8Ichiei Narita9Fumitake Gejyo10Hironobu Naiki11Suguru Yamamoto12Yuji Goto13Global Center for Medical Engineering and Informatics, Osaka University, SuitaGlobal Center for Medical Engineering and Informatics, Osaka University, SuitaGraduate School of Human and Environmental Studies, Kyoto University, Yoshidahonmatsu-cho, Sakyo-kuDepartment of Neurology, Graduate School of Medicine, Osaka University, SuitaDepartment of Neurology, Graduate School of Medicine, Osaka University, SuitaDepartment of Neurology, Graduate School of Medicine, Osaka University, SuitaGraduate School of Engineering, Osaka University, SuitaGraduate School of Engineering, Osaka University, SuitaDivision of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Niigata UniversityDivision of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Niigata UniversityNiigata University of Pharmacy and Applied Life SciencesFaculty of Medical Sciences, University of FukuiDivision of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Niigata UniversityGlobal Center for Medical Engineering and Informatics, Osaka University, SuitaAmyloid fibrils of β2-microglobulin (β2m) can cause dialysis-related amyloidosis. Here, the authors show that a decrease in serum albumin levels in long-term dialysis deteriorates the inhibitory effects of serum milieux on supersaturation-limited amyloid formation of β2m, suggesting that macromolecular crowding protects the onset of amyloidosis.https://doi.org/10.1038/s41467-022-33247-3 |
| spellingShingle | Kichitaro Nakajima Keiichi Yamaguchi Masahiro Noji César Aguirre Kensuke Ikenaka Hideki Mochizuki Lianjie Zhou Hirotsugu Ogi Toru Ito Ichiei Narita Fumitake Gejyo Hironobu Naiki Suguru Yamamoto Yuji Goto Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis Nature Communications |
| title | Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis |
| title_full | Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis |
| title_fullStr | Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis |
| title_full_unstemmed | Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis |
| title_short | Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis |
| title_sort | macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis related amyloidosis |
| url | https://doi.org/10.1038/s41467-022-33247-3 |
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