Inhibition of <i>Leishmania infantum</i> Trypanothione Reductase by New Aminopropanone Derivatives Interacting with the NADPH Binding Site

Inhibition of <i>Leishmania infantum</i> Trypanothione Reductase by New Aminopropanone Derivatives Interacting with the NADPH Binding Site

Background: As a result of the paucity of treatment, Leishmaniasis continues to provoke about 60,000 deaths every year worldwide. New molecules are needed, and drug discovery research is oriented toward targeting proteins crucial for parasite survival. Among them, trypanothione reductase (TR) is of...

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Bibliographic Details
Main Authors: Valentina Noemi Madia, Davide Ialongo, Elisa Patacchini, Cécile Exertier, Lorenzo Antonelli, Gianni Colotti, Antonella Messore, Valeria Tudino, Francesco Saccoliti, Luigi Scipione, Andrea Ilari, Roberta Costi, Roberto Di Santo
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
<i>Leishmania infantum</i>
trypanothione reductase inhibition
X-ray crystal structure
NADPH binding site
procaine derivatives
procainamide derivatives
Online Access:https://www.mdpi.com/1420-3049/28/1/338

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