Simultaneous Effect of Aerobic Training and Resveratrol Supplementation on Interleukin-6 Serum Levels in Women With Type 2 Diabetes
Background and Aims Diabetes pathogenesis is driven by a complex network of pro-inflammatory cells and cytokines, of which interleukin-6 (IL-6) plays a key role in the chronic inflammation associated with type 2 diabetes. The use of supplements and plant extracts and exercise to treat type 2 diabete...
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| Format: | Article |
| Language: | fas |
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Shahid Beheshti University of Medical Sciences
2022-07-01
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| Series: | Ṭibb-i Tavānbakhshī |
| Subjects: | |
| Online Access: | http://medrehab.sbmu.ac.ir/article_1101309_2d1773590f7a0ebc705a4948568fd4f4.pdf?lang=en |
| _version_ | 1811336049940496384 |
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| author | Ensiyeh Yazdkhasti Farnaz Seifi-SkiShahr Mohammad Ebrahim Bahram |
| author_facet | Ensiyeh Yazdkhasti Farnaz Seifi-SkiShahr Mohammad Ebrahim Bahram |
| author_sort | Ensiyeh Yazdkhasti |
| collection | DOAJ |
| description | Background and Aims Diabetes pathogenesis is driven by a complex network of pro-inflammatory cells and cytokines, of which interleukin-6 (IL-6) plays a key role in the chronic inflammation associated with type 2 diabetes. The use of supplements and plant extracts and exercise to treat type 2 diabetes is common today. The aim of this study was to evaluate the simultaneous effect of aerobic training and resveratrol supplementation on IL-6serum levels in women with type 2 diabetes.
Methods This study was a quasi-experimental study with a pre-test-post-test design and a control group, in which 24 women with type 2 diabetes were randomly assigned to three equal groups of supplement (age 55.25±5.11 years), training+supplement (400 mg resveratrol) (age 54.62±7.22 years), and control (age 52.25±8.60 years). The subjects practiced for six weeks and every week for three days for 40-60 min and at a heart rate of 45-65. Data analysis was performed using analysis of covariance and correlated t-test at the significant level of <0.05.
Results The results showed that after the intervention, IL-6 serum levels in the aerobic training + supplement group (P=0.01) had a significant decrease compared to the supplement and control groups. Examination of intergroup changes shows that there was a significant difference in IL-6 levels between the training + supplement group and the supplement group (P=0.002, f=1.56). Also, the results of the Tukey post hoc test showed that there was a significant difference between the control group and the training + supplement group (P=0.003) and between the supplement group and the training+supplement group in IL-6 levels (P=0.031).
Conclusion Based on the findings of the present study, it seems that concomitant use of resveratrol supplementation and aerobic training can reduce the levels of IL-6 and the supplement have anti-inflammatory and protective effects in women with type 2 diabetes. |
| first_indexed | 2024-04-13T17:32:50Z |
| format | Article |
| id | doaj.art-d810c014d94a481b9fb0f326e44eedbe |
| institution | Directory Open Access Journal |
| issn | 2251-8401 2252-0414 |
| language | fas |
| last_indexed | 2024-04-13T17:32:50Z |
| publishDate | 2022-07-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
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| series | Ṭibb-i Tavānbakhshī |
| spelling | doaj.art-d810c014d94a481b9fb0f326e44eedbe2022-12-22T02:37:30ZfasShahid Beheshti University of Medical SciencesṬibb-i Tavānbakhshī2251-84012252-04142022-07-0111310.32598/SJRM.11.3.9Simultaneous Effect of Aerobic Training and Resveratrol Supplementation on Interleukin-6 Serum Levels in Women With Type 2 DiabetesEnsiyeh YazdkhastiFarnaz Seifi-SkiShahrMohammad Ebrahim BahramBackground and Aims Diabetes pathogenesis is driven by a complex network of pro-inflammatory cells and cytokines, of which interleukin-6 (IL-6) plays a key role in the chronic inflammation associated with type 2 diabetes. The use of supplements and plant extracts and exercise to treat type 2 diabetes is common today. The aim of this study was to evaluate the simultaneous effect of aerobic training and resveratrol supplementation on IL-6serum levels in women with type 2 diabetes. Methods This study was a quasi-experimental study with a pre-test-post-test design and a control group, in which 24 women with type 2 diabetes were randomly assigned to three equal groups of supplement (age 55.25±5.11 years), training+supplement (400 mg resveratrol) (age 54.62±7.22 years), and control (age 52.25±8.60 years). The subjects practiced for six weeks and every week for three days for 40-60 min and at a heart rate of 45-65. Data analysis was performed using analysis of covariance and correlated t-test at the significant level of <0.05. Results The results showed that after the intervention, IL-6 serum levels in the aerobic training + supplement group (P=0.01) had a significant decrease compared to the supplement and control groups. Examination of intergroup changes shows that there was a significant difference in IL-6 levels between the training + supplement group and the supplement group (P=0.002, f=1.56). Also, the results of the Tukey post hoc test showed that there was a significant difference between the control group and the training + supplement group (P=0.003) and between the supplement group and the training+supplement group in IL-6 levels (P=0.031). Conclusion Based on the findings of the present study, it seems that concomitant use of resveratrol supplementation and aerobic training can reduce the levels of IL-6 and the supplement have anti-inflammatory and protective effects in women with type 2 diabetes.http://medrehab.sbmu.ac.ir/article_1101309_2d1773590f7a0ebc705a4948568fd4f4.pdf?lang=enaerobic traininginterleukin-6diabetic mellitusresveratrol supplement |
| spellingShingle | Ensiyeh Yazdkhasti Farnaz Seifi-SkiShahr Mohammad Ebrahim Bahram Simultaneous Effect of Aerobic Training and Resveratrol Supplementation on Interleukin-6 Serum Levels in Women With Type 2 Diabetes Ṭibb-i Tavānbakhshī aerobic training interleukin-6 diabetic mellitus resveratrol supplement |
| title | Simultaneous Effect of Aerobic Training and Resveratrol Supplementation on Interleukin-6 Serum Levels in Women With Type 2 Diabetes |
| title_full | Simultaneous Effect of Aerobic Training and Resveratrol Supplementation on Interleukin-6 Serum Levels in Women With Type 2 Diabetes |
| title_fullStr | Simultaneous Effect of Aerobic Training and Resveratrol Supplementation on Interleukin-6 Serum Levels in Women With Type 2 Diabetes |
| title_full_unstemmed | Simultaneous Effect of Aerobic Training and Resveratrol Supplementation on Interleukin-6 Serum Levels in Women With Type 2 Diabetes |
| title_short | Simultaneous Effect of Aerobic Training and Resveratrol Supplementation on Interleukin-6 Serum Levels in Women With Type 2 Diabetes |
| title_sort | simultaneous effect of aerobic training and resveratrol supplementation on interleukin 6 serum levels in women with type 2 diabetes |
| topic | aerobic training interleukin-6 diabetic mellitus resveratrol supplement |
| url | http://medrehab.sbmu.ac.ir/article_1101309_2d1773590f7a0ebc705a4948568fd4f4.pdf?lang=en |
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