Is Systemic Immunosuppression a Risk Factor for Oral Cancer? A Systematic Review and Meta-Analysis
Even if the relationship between immunosuppression and increased incidence of systemic cancers is well known, there is less awareness about the risk of developing oral cancer in immunosuppressed patients. The aim of this review was to evaluate the association between immunosuppression and the develo...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/12/3077 |
| _version_ | 1797595631155412992 |
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| author | Romeo Patini Massimo Cordaro Denise Marchesini Francesco Scilla Gioele Gioco Cosimo Rupe Maria Antonietta D’Agostino Carlo Lajolo |
| author_facet | Romeo Patini Massimo Cordaro Denise Marchesini Francesco Scilla Gioele Gioco Cosimo Rupe Maria Antonietta D’Agostino Carlo Lajolo |
| author_sort | Romeo Patini |
| collection | DOAJ |
| description | Even if the relationship between immunosuppression and increased incidence of systemic cancers is well known, there is less awareness about the risk of developing oral cancer in immunosuppressed patients. The aim of this review was to evaluate the association between immunosuppression and the development of oral cancer. Two authors independently and, in duplicate, conducted a systematic literature review of international journals and electronic databases (MEDLINE via OVID, Scopus, and Web of Science) from their inception to 28 April 2023. The assessment of risk of bias and overall quality of evidence was performed using the Newcastle–Ottawa Scale and GRADE system. A total of 2843 articles was identified, of which 44 met the inclusion criteria and were included in either the qualitative or quantitative analysis. The methodological quality of the included studies was generally high or moderate. The quantitative analysis of the studies revealed that immunosuppression should be considered a risk factor for the development of oral cancer, with a percentage of increased risk ranging from 0.2% to 1% (95% CI: 0.2% to 1.4%). In conclusion, the results suggest that a constant and accurate follow-up should be reserved for all immunosuppressed patients as a crucial strategy to intercept lesions that have an increased potential to evolve into oral cancer. |
| first_indexed | 2024-03-11T02:40:11Z |
| format | Article |
| id | doaj.art-d81366f3e17e403cbcacd316f9e14903 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T02:40:11Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-d81366f3e17e403cbcacd316f9e149032023-11-18T09:40:21ZengMDPI AGCancers2072-66942023-06-011512307710.3390/cancers15123077Is Systemic Immunosuppression a Risk Factor for Oral Cancer? A Systematic Review and Meta-AnalysisRomeo Patini0Massimo Cordaro1Denise Marchesini2Francesco Scilla3Gioele Gioco4Cosimo Rupe5Maria Antonietta D’Agostino6Carlo Lajolo7Department of Head, Neck and Sense Organs, School of Dentistry, Catholic University of Sacred Heart, Fondazione Policlinico Universitario “A. Gemelli”—IRCCS Rome, 00135 Rome, ItalyDepartment of Head, Neck and Sense Organs, School of Dentistry, Catholic University of Sacred Heart, Fondazione Policlinico Universitario “A. Gemelli”—IRCCS Rome, 00135 Rome, ItalyDepartment of Head, Neck and Sense Organs, School of Dentistry, Catholic University of Sacred Heart, Fondazione Policlinico Universitario “A. Gemelli”—IRCCS Rome, 00135 Rome, ItalyDepartment of Head, Neck and Sense Organs, School of Dentistry, Catholic University of Sacred Heart, Fondazione Policlinico Universitario “A. Gemelli”—IRCCS Rome, 00135 Rome, ItalyDepartment of Head, Neck and Sense Organs, School of Dentistry, Catholic University of Sacred Heart, Fondazione Policlinico Universitario “A. Gemelli”—IRCCS Rome, 00135 Rome, ItalyDepartment of Head, Neck and Sense Organs, School of Dentistry, Catholic University of Sacred Heart, Fondazione Policlinico Universitario “A. Gemelli”—IRCCS Rome, 00135 Rome, ItalyDepartment of Geriatric and Orthopedic Sciences, Catholic University of Sacred Heart, Fondazione Policlinico Universitario “A. Gemelli”—IRCCS Rome, 00135 Rome, ItalyDepartment of Head, Neck and Sense Organs, School of Dentistry, Catholic University of Sacred Heart, Fondazione Policlinico Universitario “A. Gemelli”—IRCCS Rome, 00135 Rome, ItalyEven if the relationship between immunosuppression and increased incidence of systemic cancers is well known, there is less awareness about the risk of developing oral cancer in immunosuppressed patients. The aim of this review was to evaluate the association between immunosuppression and the development of oral cancer. Two authors independently and, in duplicate, conducted a systematic literature review of international journals and electronic databases (MEDLINE via OVID, Scopus, and Web of Science) from their inception to 28 April 2023. The assessment of risk of bias and overall quality of evidence was performed using the Newcastle–Ottawa Scale and GRADE system. A total of 2843 articles was identified, of which 44 met the inclusion criteria and were included in either the qualitative or quantitative analysis. The methodological quality of the included studies was generally high or moderate. The quantitative analysis of the studies revealed that immunosuppression should be considered a risk factor for the development of oral cancer, with a percentage of increased risk ranging from 0.2% to 1% (95% CI: 0.2% to 1.4%). In conclusion, the results suggest that a constant and accurate follow-up should be reserved for all immunosuppressed patients as a crucial strategy to intercept lesions that have an increased potential to evolve into oral cancer.https://www.mdpi.com/2072-6694/15/12/3077immunosuppressionoral cancersystematic reviewmeta-analysis |
| spellingShingle | Romeo Patini Massimo Cordaro Denise Marchesini Francesco Scilla Gioele Gioco Cosimo Rupe Maria Antonietta D’Agostino Carlo Lajolo Is Systemic Immunosuppression a Risk Factor for Oral Cancer? A Systematic Review and Meta-Analysis Cancers immunosuppression oral cancer systematic review meta-analysis |
| title | Is Systemic Immunosuppression a Risk Factor for Oral Cancer? A Systematic Review and Meta-Analysis |
| title_full | Is Systemic Immunosuppression a Risk Factor for Oral Cancer? A Systematic Review and Meta-Analysis |
| title_fullStr | Is Systemic Immunosuppression a Risk Factor for Oral Cancer? A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Is Systemic Immunosuppression a Risk Factor for Oral Cancer? A Systematic Review and Meta-Analysis |
| title_short | Is Systemic Immunosuppression a Risk Factor for Oral Cancer? A Systematic Review and Meta-Analysis |
| title_sort | is systemic immunosuppression a risk factor for oral cancer a systematic review and meta analysis |
| topic | immunosuppression oral cancer systematic review meta-analysis |
| url | https://www.mdpi.com/2072-6694/15/12/3077 |
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