Maternal microbiome disturbance induces deficits in the offspring’s behaviors: a systematic review and meta-analysis
ABSTRACTRecent evidence has suggested that changes in maternal gut microbiota in early life may generate neurobiological consequences associated with psychiatric-related abnormalities. However, the number of studies on humans investigating this problem is limited, and preclinical findings sometimes...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2226282 |
| _version_ | 1797236683931910144 |
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| author | Lucas Hassib Cilene Lino de Oliveira Guilherme Araujo Rouvier Alexandre Kanashiro Francisco Silveira Guimarães Frederico Rogério Ferreira |
| author_facet | Lucas Hassib Cilene Lino de Oliveira Guilherme Araujo Rouvier Alexandre Kanashiro Francisco Silveira Guimarães Frederico Rogério Ferreira |
| author_sort | Lucas Hassib |
| collection | DOAJ |
| description | ABSTRACTRecent evidence has suggested that changes in maternal gut microbiota in early life may generate neurobiological consequences associated with psychiatric-related abnormalities. However, the number of studies on humans investigating this problem is limited, and preclinical findings sometimes conflict. Therefore, we run a meta-analysis to examine whether maternal microbiota disturbance (MMD) during neurodevelopment might affect the offspring during adulthood. We found thirteen studies, from a set of 459 records selected by strategy registered on PROSPERO (#289224), to target preclinical studies that evaluated the behavioral outcomes of the rodents generated by dams submitted to perinatal enteric microbiota perturbation. The analysis revealed a significant effect size (SMD = −0.51, 95% CI = −0.79 to −0.22, p < .001, T2 = 0.54, I2 = 79.85%), indicating that MMD might provoke behavioral impairments in the adult offspring. The MMD also induces a significant effect size for the reduction of the sociability behavior (SMD = −0.63, 95% CI = −1.18 to −0.07, p = 0.011, T2 = 0.30, I2 = 76.11%) and obsessive-compulsive-like behavior (SMD = −0.68, 95% CI = −0.01 to −1.36, p = 0.009, T2 = 0.25, I2 = 62.82%) parameters. The effect size was not significant or inconclusive for memory and anxiety-like behavior, or inconclusive for schizophrenia-like and depressive-like behavior. Therefore, experimental perinatal MMD is vertically transmitted to the offspring, negatively impacting behavioral parameters related to psychiatric disorders. |
| first_indexed | 2024-03-11T14:20:48Z |
| format | Article |
| id | doaj.art-d8141a2f690645f985e8cf1afcb946e7 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-24T17:07:45Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-d8141a2f690645f985e8cf1afcb946e72024-03-28T22:38:20ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115110.1080/19490976.2023.2226282Maternal microbiome disturbance induces deficits in the offspring’s behaviors: a systematic review and meta-analysisLucas Hassib0Cilene Lino de Oliveira1Guilherme Araujo Rouvier2Alexandre Kanashiro3Francisco Silveira Guimarães4Frederico Rogério Ferreira5Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilDepartment of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, BrazilOswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilDepartment of Dermatology, Medical Sciences Center, University of Wisconsin-Madison, Madison, WI, USADepartment of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, BrazilOswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilABSTRACTRecent evidence has suggested that changes in maternal gut microbiota in early life may generate neurobiological consequences associated with psychiatric-related abnormalities. However, the number of studies on humans investigating this problem is limited, and preclinical findings sometimes conflict. Therefore, we run a meta-analysis to examine whether maternal microbiota disturbance (MMD) during neurodevelopment might affect the offspring during adulthood. We found thirteen studies, from a set of 459 records selected by strategy registered on PROSPERO (#289224), to target preclinical studies that evaluated the behavioral outcomes of the rodents generated by dams submitted to perinatal enteric microbiota perturbation. The analysis revealed a significant effect size (SMD = −0.51, 95% CI = −0.79 to −0.22, p < .001, T2 = 0.54, I2 = 79.85%), indicating that MMD might provoke behavioral impairments in the adult offspring. The MMD also induces a significant effect size for the reduction of the sociability behavior (SMD = −0.63, 95% CI = −1.18 to −0.07, p = 0.011, T2 = 0.30, I2 = 76.11%) and obsessive-compulsive-like behavior (SMD = −0.68, 95% CI = −0.01 to −1.36, p = 0.009, T2 = 0.25, I2 = 62.82%) parameters. The effect size was not significant or inconclusive for memory and anxiety-like behavior, or inconclusive for schizophrenia-like and depressive-like behavior. Therefore, experimental perinatal MMD is vertically transmitted to the offspring, negatively impacting behavioral parameters related to psychiatric disorders.https://www.tandfonline.com/doi/10.1080/19490976.2023.2226282Maternal microbiome disturbanceneurodevelopmentgut-brain axispsychiatric disordersociabilityautism spectrum disorder |
| spellingShingle | Lucas Hassib Cilene Lino de Oliveira Guilherme Araujo Rouvier Alexandre Kanashiro Francisco Silveira Guimarães Frederico Rogério Ferreira Maternal microbiome disturbance induces deficits in the offspring’s behaviors: a systematic review and meta-analysis Gut Microbes Maternal microbiome disturbance neurodevelopment gut-brain axis psychiatric disorder sociability autism spectrum disorder |
| title | Maternal microbiome disturbance induces deficits in the offspring’s behaviors: a systematic review and meta-analysis |
| title_full | Maternal microbiome disturbance induces deficits in the offspring’s behaviors: a systematic review and meta-analysis |
| title_fullStr | Maternal microbiome disturbance induces deficits in the offspring’s behaviors: a systematic review and meta-analysis |
| title_full_unstemmed | Maternal microbiome disturbance induces deficits in the offspring’s behaviors: a systematic review and meta-analysis |
| title_short | Maternal microbiome disturbance induces deficits in the offspring’s behaviors: a systematic review and meta-analysis |
| title_sort | maternal microbiome disturbance induces deficits in the offspring s behaviors a systematic review and meta analysis |
| topic | Maternal microbiome disturbance neurodevelopment gut-brain axis psychiatric disorder sociability autism spectrum disorder |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2226282 |
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