Postoperative pain management in non-traumatic emergency general surgery: WSES-GAIS-SIAARTI-AAST guidelines

Abstract Background Non-traumatic emergency general surgery involves a heterogeneous population that may present with several underlying diseases. Timeous emergency surgical treatment should be supplemented with high-quality perioperative care, ideally performed by multidisciplinary teams trained to...

Full description

Bibliographic Details
Main Authors: Federico Coccolini, Francesco Corradi, Massimo Sartelli, Raul Coimbra, Igor A. Kryvoruchko, Ari Leppaniemi, Krstina Doklestic, Elena Bignami, Giandomenico Biancofiore, Miklosh Bala, Ceresoli Marco, Dimitris Damaskos, Walt L. Biffl, Paola Fugazzola, Domenico Santonastaso, Vanni Agnoletti, Catia Sbarbaro, Mirco Nacoti, Timothy C. Hardcastle, Diego Mariani, Belinda De Simone, Matti Tolonen, Chad Ball, Mauro Podda, Isidoro Di Carlo, Salomone Di Saverio, Pradeep Navsaria, Luigi Bonavina, Fikri Abu-Zidan, Kjetil Soreide, Gustavo P. Fraga, Vanessa Henriques Carvalho, Sergio Faria Batista, Andreas Hecker, Alessandro Cucchetti, Giorgio Ercolani, Dario Tartaglia, Joseph M. Galante, Imtiaz Wani, Hayato Kurihara, Edward Tan, Andrey Litvin, Rita Maria Melotti, Gabriele Sganga, Tamara Zoro, Alessandro Isirdi, Nicola De’Angelis, Dieter G. Weber, Adrien M. Hodonou, Richard tenBroek, Dario Parini, Jim Khan, Giovanni Sbrana, Carlo Coniglio, Antonino Giarratano, Angelo Gratarola, Claudia Zaghi, Oreste Romeo, Michael Kelly, Francesco Forfori, Massimo Chiarugi, Ernest E. Moore, Fausto Catena, Manu L. N. G. Malbrain
Format: Article
Language:English
Published: BMC 2022-09-01
Series:World Journal of Emergency Surgery
Subjects:
Online Access:https://doi.org/10.1186/s13017-022-00455-7
_version_ 1798001642074800128
author Federico Coccolini
Francesco Corradi
Massimo Sartelli
Raul Coimbra
Igor A. Kryvoruchko
Ari Leppaniemi
Krstina Doklestic
Elena Bignami
Giandomenico Biancofiore
Miklosh Bala
Ceresoli Marco
Dimitris Damaskos
Walt L. Biffl
Paola Fugazzola
Domenico Santonastaso
Vanni Agnoletti
Catia Sbarbaro
Mirco Nacoti
Timothy C. Hardcastle
Diego Mariani
Belinda De Simone
Matti Tolonen
Chad Ball
Mauro Podda
Isidoro Di Carlo
Salomone Di Saverio
Pradeep Navsaria
Luigi Bonavina
Fikri Abu-Zidan
Kjetil Soreide
Gustavo P. Fraga
Vanessa Henriques Carvalho
Sergio Faria Batista
Andreas Hecker
Alessandro Cucchetti
Giorgio Ercolani
Dario Tartaglia
Joseph M. Galante
Imtiaz Wani
Hayato Kurihara
Edward Tan
Andrey Litvin
Rita Maria Melotti
Gabriele Sganga
Tamara Zoro
Alessandro Isirdi
Nicola De’Angelis
Dieter G. Weber
Adrien M. Hodonou
Richard tenBroek
Dario Parini
Jim Khan
Giovanni Sbrana
Carlo Coniglio
Antonino Giarratano
Angelo Gratarola
Claudia Zaghi
Oreste Romeo
Michael Kelly
Francesco Forfori
Massimo Chiarugi
Ernest E. Moore
Fausto Catena
Manu L. N. G. Malbrain
author_facet Federico Coccolini
Francesco Corradi
Massimo Sartelli
Raul Coimbra
Igor A. Kryvoruchko
Ari Leppaniemi
Krstina Doklestic
Elena Bignami
Giandomenico Biancofiore
Miklosh Bala
Ceresoli Marco
Dimitris Damaskos
Walt L. Biffl
Paola Fugazzola
Domenico Santonastaso
Vanni Agnoletti
Catia Sbarbaro
Mirco Nacoti
Timothy C. Hardcastle
Diego Mariani
Belinda De Simone
Matti Tolonen
Chad Ball
Mauro Podda
Isidoro Di Carlo
Salomone Di Saverio
Pradeep Navsaria
Luigi Bonavina
Fikri Abu-Zidan
Kjetil Soreide
Gustavo P. Fraga
Vanessa Henriques Carvalho
Sergio Faria Batista
Andreas Hecker
Alessandro Cucchetti
Giorgio Ercolani
Dario Tartaglia
Joseph M. Galante
Imtiaz Wani
Hayato Kurihara
Edward Tan
Andrey Litvin
Rita Maria Melotti
Gabriele Sganga
Tamara Zoro
Alessandro Isirdi
Nicola De’Angelis
Dieter G. Weber
Adrien M. Hodonou
Richard tenBroek
Dario Parini
Jim Khan
Giovanni Sbrana
Carlo Coniglio
Antonino Giarratano
Angelo Gratarola
Claudia Zaghi
Oreste Romeo
Michael Kelly
Francesco Forfori
Massimo Chiarugi
Ernest E. Moore
Fausto Catena
Manu L. N. G. Malbrain
author_sort Federico Coccolini
collection DOAJ
description Abstract Background Non-traumatic emergency general surgery involves a heterogeneous population that may present with several underlying diseases. Timeous emergency surgical treatment should be supplemented with high-quality perioperative care, ideally performed by multidisciplinary teams trained to identify and handle complex postoperative courses. Uncontrolled or poorly controlled acute postoperative pain may result in significant complications. While pain management after elective surgery has been standardized in perioperative pathways, the traditional perioperative treatment of patients undergoing emergency surgery is often a haphazard practice. The present recommended pain management guidelines are for pain management after non-traumatic emergency surgical intervention. It is meant to provide clinicians a list of indications to prescribe the optimal analgesics even in the absence of a multidisciplinary pain team. Material and methods An international expert panel discussed the different issues in subsequent rounds. Four international recognized scientific societies: World Society of Emergency Surgery (WSES), Global Alliance for Infection in Surgery (GAIS), Italian Society of Anesthesia, Analgesia Intensive Care (SIAARTI), and American Association for the Surgery of Trauma (AAST), endorsed the project and approved the final manuscript. Conclusion Dealing with acute postoperative pain in the emergency abdominal surgery setting is complex, requires special attention, and should be multidisciplinary. Several tools are available, and their combination is mandatory whenever is possible. Analgesic approach to the various situations and conditions should be patient based and tailored according to procedure, pathology, age, response, and available expertise. A better understanding of the patho-mechanisms of postoperative pain for short- and long-term outcomes is necessary to improve prophylactic and treatment strategies.
first_indexed 2024-04-11T11:39:32Z
format Article
id doaj.art-d814a297032c4be8a58c5834c6fb7995
institution Directory Open Access Journal
issn 1749-7922
language English
last_indexed 2024-04-11T11:39:32Z
publishDate 2022-09-01
publisher BMC
record_format Article
series World Journal of Emergency Surgery
spelling doaj.art-d814a297032c4be8a58c5834c6fb79952022-12-22T04:25:52ZengBMCWorld Journal of Emergency Surgery1749-79222022-09-0117111510.1186/s13017-022-00455-7Postoperative pain management in non-traumatic emergency general surgery: WSES-GAIS-SIAARTI-AAST guidelinesFederico Coccolini0Francesco Corradi1Massimo Sartelli2Raul Coimbra3Igor A. Kryvoruchko4Ari Leppaniemi5Krstina Doklestic6Elena Bignami7Giandomenico Biancofiore8Miklosh Bala9Ceresoli Marco10Dimitris Damaskos11Walt L. Biffl12Paola Fugazzola13Domenico Santonastaso14Vanni Agnoletti15Catia Sbarbaro16Mirco Nacoti17Timothy C. Hardcastle18Diego Mariani19Belinda De Simone20Matti Tolonen21Chad Ball22Mauro Podda23Isidoro Di Carlo24Salomone Di Saverio25Pradeep Navsaria26Luigi Bonavina27Fikri Abu-Zidan28Kjetil Soreide29Gustavo P. Fraga30Vanessa Henriques Carvalho31Sergio Faria Batista32Andreas Hecker33Alessandro Cucchetti34Giorgio Ercolani35Dario Tartaglia36Joseph M. Galante37Imtiaz Wani38Hayato Kurihara39Edward Tan40Andrey Litvin41Rita Maria Melotti42Gabriele Sganga43Tamara Zoro44Alessandro Isirdi45Nicola De’Angelis46Dieter G. Weber47Adrien M. Hodonou48Richard tenBroek49Dario Parini50Jim Khan51Giovanni Sbrana52Carlo Coniglio53Antonino Giarratano54Angelo Gratarola55Claudia Zaghi56Oreste Romeo57Michael Kelly58Francesco Forfori59Massimo Chiarugi60Ernest E. Moore61Fausto Catena62Manu L. N. G. Malbrain63General, Emergency and Trauma Surgery Department, Pisa University HospitalICU Department, Pisa University HospitalGeneral Surgery Department, Macerata HospitalTrauma Surgery Department, Riverside University Health System Medical CenterDepartment of Surgery No2, Kharkiv National Medical UniversityGeneral Surgery Department, Helsinki University HospitalClinic of Emergency Surgery, University Clinical Center of SerbiaICU Department, Parma University HospitalTransplant ICU Department, Pisa University HospitalTrauma and Acute Care Surgery Unit Hadassah, Hebrew University Medical CenterGeneral Surgery Department, Monza University HospitalGeneral and Emergency Surgery, Royal Infirmary of EdinburghTrauma/Acute Care Surgery, Scripps Clinic Medical GroupGeneral Surgery Department, Pavia University HospitalICU Department, Bufalini HospitalICU Department, Bufalini HospitalICU Department, Pisa University HospitalICU Department Papa Giovanni XXIII HospitalTrauma and Burn Service, Inkosi Albert Luthuli Central HospitalGeneral Surgery Department, Legnano HospitalEmergency and Colorectal Surgery, Poissy and Saint Germain en Laye HospitalsEmergency Surgery, HUS Helsinki University Hospital, Meilahti Tower HospitalTrauma and Acute Care Surgery, Foothills Medical CenterDepartment of Surgical Science, University of CagliariGeneral Surgery, Cannizzaro University HospitalGeneral Surgery Department, San Benedetto del Tronto HospitalTrauma Center, Groote Schuur Hospital, University of Cape TownGeneral Surgery Department, San Donato HospitalDepartment of Surgery, College of Medicine and Health Sciences, United Arab Emirates UniversityDepartment of Gastrointestinal Surgery, Stavanger University Hospital, University of BergenDivision of Trauma Surgery, School of Medical Sciences, University of CampinasICU Department, School of Medical Sciences, University of CampinasAnesthesia Department, School of Medical SciencesGeneral Surgery, Giessen University HospitalDepartment of Medical and Surgical Sciences – DIMEC, Alma Mater Studiorum - University of Bologna, General Surgery of the Morgagni - Pierantoni HospitalDepartment of Medical and Surgical Sciences – DIMEC, Alma Mater Studiorum - University of Bologna, General Surgery of the Morgagni - Pierantoni HospitalGeneral, Emergency and Trauma Surgery Department, Pisa University HospitalGeneral Surgery Department, UCLA Davis University HospitalGeneral Surgery Department, Government Gousiua HospitalEmergency and Trauma Surgery Department, Milano University HospitalEmergency Department, Nijmegen HospitalDepartment of Surgical Disciplines, Immanuel Kant Baltic Federal University, Regional Clinical HospitalBologna UniversityFondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro CuoreICU Department, Pisa University HospitalICU Department, Pisa University HospitalService de Chirurgie Digestive Et Hépato-Bilio-Pancréatique, Hôpital Henri Mondor, Université Paris EstDepartment of General Surgery, Royal Perth HospitalFaculty of Medicine of Parakou, University of ParakouGeneral Surgery Department, Nijmegen HospitalGeneral Surgery Department, Santa Maria Della Misericordia HospitalUniversity of Portsmouth, Portsmouth Hospitals University NHS Trust UKICU-HEMS Department, Arezzo HospitalICU Department, Maggiore HospitalICU Department, P. Giaccone HospitalICU Department, San Martino HospitalGeneral, Emergency and Trauma Surgery Department, Vicenza HospitalTrauma and Surgical Critical Care, East Medical Center Drive, University of Michigan Health SystemDepartment of General Surgery, Albury HospitalICU Department, Pisa University HospitalGeneral, Emergency and Trauma Surgery Department, Pisa University HospitalE. Moore Shock and Trauma CentreGeneral, Emergency and Trauma Surgery Department, Bufalini HospitalFirst Department Anaesthesiology Intensive Therapy, Medical University LublinAbstract Background Non-traumatic emergency general surgery involves a heterogeneous population that may present with several underlying diseases. Timeous emergency surgical treatment should be supplemented with high-quality perioperative care, ideally performed by multidisciplinary teams trained to identify and handle complex postoperative courses. Uncontrolled or poorly controlled acute postoperative pain may result in significant complications. While pain management after elective surgery has been standardized in perioperative pathways, the traditional perioperative treatment of patients undergoing emergency surgery is often a haphazard practice. The present recommended pain management guidelines are for pain management after non-traumatic emergency surgical intervention. It is meant to provide clinicians a list of indications to prescribe the optimal analgesics even in the absence of a multidisciplinary pain team. Material and methods An international expert panel discussed the different issues in subsequent rounds. Four international recognized scientific societies: World Society of Emergency Surgery (WSES), Global Alliance for Infection in Surgery (GAIS), Italian Society of Anesthesia, Analgesia Intensive Care (SIAARTI), and American Association for the Surgery of Trauma (AAST), endorsed the project and approved the final manuscript. Conclusion Dealing with acute postoperative pain in the emergency abdominal surgery setting is complex, requires special attention, and should be multidisciplinary. Several tools are available, and their combination is mandatory whenever is possible. Analgesic approach to the various situations and conditions should be patient based and tailored according to procedure, pathology, age, response, and available expertise. A better understanding of the patho-mechanisms of postoperative pain for short- and long-term outcomes is necessary to improve prophylactic and treatment strategies.https://doi.org/10.1186/s13017-022-00455-7MorbidityAcutePainTreatmentEmergencySurgery
spellingShingle Federico Coccolini
Francesco Corradi
Massimo Sartelli
Raul Coimbra
Igor A. Kryvoruchko
Ari Leppaniemi
Krstina Doklestic
Elena Bignami
Giandomenico Biancofiore
Miklosh Bala
Ceresoli Marco
Dimitris Damaskos
Walt L. Biffl
Paola Fugazzola
Domenico Santonastaso
Vanni Agnoletti
Catia Sbarbaro
Mirco Nacoti
Timothy C. Hardcastle
Diego Mariani
Belinda De Simone
Matti Tolonen
Chad Ball
Mauro Podda
Isidoro Di Carlo
Salomone Di Saverio
Pradeep Navsaria
Luigi Bonavina
Fikri Abu-Zidan
Kjetil Soreide
Gustavo P. Fraga
Vanessa Henriques Carvalho
Sergio Faria Batista
Andreas Hecker
Alessandro Cucchetti
Giorgio Ercolani
Dario Tartaglia
Joseph M. Galante
Imtiaz Wani
Hayato Kurihara
Edward Tan
Andrey Litvin
Rita Maria Melotti
Gabriele Sganga
Tamara Zoro
Alessandro Isirdi
Nicola De’Angelis
Dieter G. Weber
Adrien M. Hodonou
Richard tenBroek
Dario Parini
Jim Khan
Giovanni Sbrana
Carlo Coniglio
Antonino Giarratano
Angelo Gratarola
Claudia Zaghi
Oreste Romeo
Michael Kelly
Francesco Forfori
Massimo Chiarugi
Ernest E. Moore
Fausto Catena
Manu L. N. G. Malbrain
Postoperative pain management in non-traumatic emergency general surgery: WSES-GAIS-SIAARTI-AAST guidelines
World Journal of Emergency Surgery
Morbidity
Acute
Pain
Treatment
Emergency
Surgery
title Postoperative pain management in non-traumatic emergency general surgery: WSES-GAIS-SIAARTI-AAST guidelines
title_full Postoperative pain management in non-traumatic emergency general surgery: WSES-GAIS-SIAARTI-AAST guidelines
title_fullStr Postoperative pain management in non-traumatic emergency general surgery: WSES-GAIS-SIAARTI-AAST guidelines
title_full_unstemmed Postoperative pain management in non-traumatic emergency general surgery: WSES-GAIS-SIAARTI-AAST guidelines
title_short Postoperative pain management in non-traumatic emergency general surgery: WSES-GAIS-SIAARTI-AAST guidelines
title_sort postoperative pain management in non traumatic emergency general surgery wses gais siaarti aast guidelines
topic Morbidity
Acute
Pain
Treatment
Emergency
Surgery
url https://doi.org/10.1186/s13017-022-00455-7
work_keys_str_mv AT federicococcolini postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT francescocorradi postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT massimosartelli postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT raulcoimbra postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT igorakryvoruchko postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT arileppaniemi postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT krstinadoklestic postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT elenabignami postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT giandomenicobiancofiore postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT mikloshbala postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT ceresolimarco postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT dimitrisdamaskos postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT waltlbiffl postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT paolafugazzola postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT domenicosantonastaso postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT vanniagnoletti postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT catiasbarbaro postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT mirconacoti postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT timothychardcastle postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT diegomariani postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT belindadesimone postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT mattitolonen postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT chadball postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT mauropodda postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT isidorodicarlo postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT salomonedisaverio postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT pradeepnavsaria postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT luigibonavina postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT fikriabuzidan postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT kjetilsoreide postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT gustavopfraga postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT vanessahenriquescarvalho postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT sergiofariabatista postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT andreashecker postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT alessandrocucchetti postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT giorgioercolani postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT dariotartaglia postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT josephmgalante postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT imtiazwani postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT hayatokurihara postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT edwardtan postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT andreylitvin postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT ritamariamelotti postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT gabrielesganga postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT tamarazoro postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT alessandroisirdi postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT nicoladeangelis postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT dietergweber postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT adrienmhodonou postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT richardtenbroek postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT darioparini postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT jimkhan postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT giovannisbrana postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT carloconiglio postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT antoninogiarratano postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT angelogratarola postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT claudiazaghi postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT oresteromeo postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT michaelkelly postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT francescoforfori postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT massimochiarugi postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT ernestemoore postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT faustocatena postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines
AT manulngmalbrain postoperativepainmanagementinnontraumaticemergencygeneralsurgerywsesgaissiaartiaastguidelines