Plasma Protein Profiling Reveal Osteoprotegerin as a Marker of Prognostic Impact for Colorectal Cancer
BACKGROUND: Due to difficulties in predicting recurrences in colorectal cancer stages II and III, reliable prognostic biomarkers could be a breakthrough for individualized treatment and follow-up. OBJECTIVE: To find potential prognostic protein biomarkers in colorectal cancer, using the proximity ex...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-08-01
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| Series: | Translational Oncology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523318301475 |
| _version_ | 1818066183945977856 |
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| author | Helgi Birgisson Kostas Tsimogiannis Eva Freyhult Masood Kamali-Moghaddam |
| author_facet | Helgi Birgisson Kostas Tsimogiannis Eva Freyhult Masood Kamali-Moghaddam |
| author_sort | Helgi Birgisson |
| collection | DOAJ |
| description | BACKGROUND: Due to difficulties in predicting recurrences in colorectal cancer stages II and III, reliable prognostic biomarkers could be a breakthrough for individualized treatment and follow-up. OBJECTIVE: To find potential prognostic protein biomarkers in colorectal cancer, using the proximity extension assays. METHODS: A panel of 92 oncology-related proteins was analyzed with proximity extension assays, in plasma from a cohort of 261 colorectal cancer patients with stage II-IV. The survival analyses were corrected for disease stage and age, and the recurrence analyses were corrected for disease stage. The significance threshold was adjusted for multiple comparisons. RESULTS: The plasma proteins expression levels had a greater prognostic relevance in disease stage III colorectal cancer than in disease stage II, and for overall survival than for time to recurrence. Osteoprotegerin was the only biomarker candidate in the protein panel that had a statistical significant association with overall survival (P = .00029). None of the proteins were statistically significantly associated with time to recurrence. CONCLUSIONS: Of the 92 analyzed plasma proteins, osteoprotegerin showed the strongest prognostic impact in patients with colorectal cancer, and therefore osteoprotegerin is a potential predictive marker, and it also could be a target for treatments. |
| first_indexed | 2024-12-10T15:03:45Z |
| format | Article |
| id | doaj.art-d814e3a544bd4b99bb635cfe4ae89c54 |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-12-10T15:03:45Z |
| publishDate | 2018-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-d814e3a544bd4b99bb635cfe4ae89c542022-12-22T01:44:07ZengElsevierTranslational Oncology1936-52332018-08-0111410341043Plasma Protein Profiling Reveal Osteoprotegerin as a Marker of Prognostic Impact for Colorectal CancerHelgi Birgisson0Kostas Tsimogiannis1Eva Freyhult2Masood Kamali-Moghaddam3Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; Address all correspondence to: Helgi Birgisson, MD, PhD, Department of Surgical Sciences, Colorectal Surgery, Uppsala University, Akademiska sjukhuset, ing. 70, 75185, Uppsala, Sweden.Department of Surgical Sciences, Uppsala University, Uppsala, SwedenDepartment of Medical Sciences, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala, SwedenDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, SwedenBACKGROUND: Due to difficulties in predicting recurrences in colorectal cancer stages II and III, reliable prognostic biomarkers could be a breakthrough for individualized treatment and follow-up. OBJECTIVE: To find potential prognostic protein biomarkers in colorectal cancer, using the proximity extension assays. METHODS: A panel of 92 oncology-related proteins was analyzed with proximity extension assays, in plasma from a cohort of 261 colorectal cancer patients with stage II-IV. The survival analyses were corrected for disease stage and age, and the recurrence analyses were corrected for disease stage. The significance threshold was adjusted for multiple comparisons. RESULTS: The plasma proteins expression levels had a greater prognostic relevance in disease stage III colorectal cancer than in disease stage II, and for overall survival than for time to recurrence. Osteoprotegerin was the only biomarker candidate in the protein panel that had a statistical significant association with overall survival (P = .00029). None of the proteins were statistically significantly associated with time to recurrence. CONCLUSIONS: Of the 92 analyzed plasma proteins, osteoprotegerin showed the strongest prognostic impact in patients with colorectal cancer, and therefore osteoprotegerin is a potential predictive marker, and it also could be a target for treatments.http://www.sciencedirect.com/science/article/pii/S1936523318301475 |
| spellingShingle | Helgi Birgisson Kostas Tsimogiannis Eva Freyhult Masood Kamali-Moghaddam Plasma Protein Profiling Reveal Osteoprotegerin as a Marker of Prognostic Impact for Colorectal Cancer Translational Oncology |
| title | Plasma Protein Profiling Reveal Osteoprotegerin as a Marker of Prognostic Impact for Colorectal Cancer |
| title_full | Plasma Protein Profiling Reveal Osteoprotegerin as a Marker of Prognostic Impact for Colorectal Cancer |
| title_fullStr | Plasma Protein Profiling Reveal Osteoprotegerin as a Marker of Prognostic Impact for Colorectal Cancer |
| title_full_unstemmed | Plasma Protein Profiling Reveal Osteoprotegerin as a Marker of Prognostic Impact for Colorectal Cancer |
| title_short | Plasma Protein Profiling Reveal Osteoprotegerin as a Marker of Prognostic Impact for Colorectal Cancer |
| title_sort | plasma protein profiling reveal osteoprotegerin as a marker of prognostic impact for colorectal cancer |
| url | http://www.sciencedirect.com/science/article/pii/S1936523318301475 |
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