Intrauterine growth and the tangential expansion of the human cerebral cortex in times of food scarcity and abundance
Abstract Tangential growth of the human cerebral cortex is driven by cell proliferation during the first and second trimester of pregnancy. Fetal growth peaks in mid-gestation. Here, we explore how genes associated with fetal growth relate to cortical growth. We find that both maternal and fetal gen...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-45409-6 |
| _version_ | 1797273989340463104 |
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| author | Daniel E. Vosberg Igor Jurisica Zdenka Pausova Tomáš Paus |
| author_facet | Daniel E. Vosberg Igor Jurisica Zdenka Pausova Tomáš Paus |
| author_sort | Daniel E. Vosberg |
| collection | DOAJ |
| description | Abstract Tangential growth of the human cerebral cortex is driven by cell proliferation during the first and second trimester of pregnancy. Fetal growth peaks in mid-gestation. Here, we explore how genes associated with fetal growth relate to cortical growth. We find that both maternal and fetal genetic variants associated with higher birthweight predict larger cortical surface area. The relative dominance of the maternal vs. fetal variants in these associations show striking variations across birth years (1943 to 1966). The birth-year patterns vary as a function of the epigenetic status near genes differentially methylated in individuals exposed (or not) to famine during the Dutch Winter of 1944/1945. Thus, it appears that the two sets of molecular processes contribute to early cortical development to a different degree in times of food scarcity or its abundance. |
| first_indexed | 2024-03-07T14:52:01Z |
| format | Article |
| id | doaj.art-d81a29eadef741f2a66e0df29083b3c2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-07T14:52:01Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d81a29eadef741f2a66e0df29083b3c22024-03-05T19:39:28ZengNature PortfolioNature Communications2041-17232024-02-011511910.1038/s41467-024-45409-6Intrauterine growth and the tangential expansion of the human cerebral cortex in times of food scarcity and abundanceDaniel E. Vosberg0Igor Jurisica1Zdenka Pausova2Tomáš Paus3Centre Hospitalier Universitaire Sainte-Justine, University of MontrealOsteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, and Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health NetworkResearch Institute of the Hospital for Sick ChildrenCentre Hospitalier Universitaire Sainte-Justine, University of MontrealAbstract Tangential growth of the human cerebral cortex is driven by cell proliferation during the first and second trimester of pregnancy. Fetal growth peaks in mid-gestation. Here, we explore how genes associated with fetal growth relate to cortical growth. We find that both maternal and fetal genetic variants associated with higher birthweight predict larger cortical surface area. The relative dominance of the maternal vs. fetal variants in these associations show striking variations across birth years (1943 to 1966). The birth-year patterns vary as a function of the epigenetic status near genes differentially methylated in individuals exposed (or not) to famine during the Dutch Winter of 1944/1945. Thus, it appears that the two sets of molecular processes contribute to early cortical development to a different degree in times of food scarcity or its abundance.https://doi.org/10.1038/s41467-024-45409-6 |
| spellingShingle | Daniel E. Vosberg Igor Jurisica Zdenka Pausova Tomáš Paus Intrauterine growth and the tangential expansion of the human cerebral cortex in times of food scarcity and abundance Nature Communications |
| title | Intrauterine growth and the tangential expansion of the human cerebral cortex in times of food scarcity and abundance |
| title_full | Intrauterine growth and the tangential expansion of the human cerebral cortex in times of food scarcity and abundance |
| title_fullStr | Intrauterine growth and the tangential expansion of the human cerebral cortex in times of food scarcity and abundance |
| title_full_unstemmed | Intrauterine growth and the tangential expansion of the human cerebral cortex in times of food scarcity and abundance |
| title_short | Intrauterine growth and the tangential expansion of the human cerebral cortex in times of food scarcity and abundance |
| title_sort | intrauterine growth and the tangential expansion of the human cerebral cortex in times of food scarcity and abundance |
| url | https://doi.org/10.1038/s41467-024-45409-6 |
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