Spinal Cord Imaging in Amyotrophic Lateral Sclerosis: Historical Concepts—Novel Techniques
Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease with no effective disease modifying therapies at present. Spinal cord degeneration is a hallmark feature of ALS, highlighted in the earliest descriptions of the disease by Lockhart Clarke and Jean-Martin Charcot....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00350/full |
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| author | Mohamed Mounir El Mendili Mohamed Mounir El Mendili Giorgia Querin Giorgia Querin Peter Bede Peter Bede Peter Bede Pierre-François Pradat Pierre-François Pradat |
| author_facet | Mohamed Mounir El Mendili Mohamed Mounir El Mendili Giorgia Querin Giorgia Querin Peter Bede Peter Bede Peter Bede Pierre-François Pradat Pierre-François Pradat |
| author_sort | Mohamed Mounir El Mendili |
| collection | DOAJ |
| description | Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease with no effective disease modifying therapies at present. Spinal cord degeneration is a hallmark feature of ALS, highlighted in the earliest descriptions of the disease by Lockhart Clarke and Jean-Martin Charcot. The anterior horns and corticospinal tracts are invariably affected in ALS, but up to recently it has been notoriously challenging to detect and characterize spinal pathology in vivo. With recent technological advances, spinal imaging now offers unique opportunities to appraise lower motor neuron degeneration, sensory involvement, metabolic alterations, and interneuron pathology in ALS. Quantitative spinal imaging in ALS has now been used in cross-sectional and longitudinal study designs, applied to presymptomatic mutation carriers, and utilized in machine learning applications. Despite its enormous clinical and academic potential, a number of physiological, technological, and methodological challenges limit the routine use of computational spinal imaging in ALS. In this review, we provide a comprehensive overview of emerging spinal cord imaging methods and discuss their advantages, drawbacks, and biomarker potential in clinical applications, clinical trial settings, monitoring, and prognostic roles. |
| first_indexed | 2024-12-11T20:14:17Z |
| format | Article |
| id | doaj.art-d81b2994aa354e1b9462f67c46d95889 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T20:14:17Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-d81b2994aa354e1b9462f67c46d958892022-12-22T00:52:13ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-04-011010.3389/fneur.2019.00350445848Spinal Cord Imaging in Amyotrophic Lateral Sclerosis: Historical Concepts—Novel TechniquesMohamed Mounir El Mendili0Mohamed Mounir El Mendili1Giorgia Querin2Giorgia Querin3Peter Bede4Peter Bede5Peter Bede6Pierre-François Pradat7Pierre-François Pradat8Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesBiomedical Imaging Laboratory (LIB), Sorbonne University, CNRS, INSERM, Paris, FranceBiomedical Imaging Laboratory (LIB), Sorbonne University, CNRS, INSERM, Paris, FranceDepartment of Neurology, Pitié-Salpêtrière University Hospital (APHP), Paris, FranceBiomedical Imaging Laboratory (LIB), Sorbonne University, CNRS, INSERM, Paris, FranceDepartment of Neurology, Pitié-Salpêtrière University Hospital (APHP), Paris, FranceComputational Neuroimaging Group, Trinity College Dublin, Dublin, IrelandBiomedical Imaging Laboratory (LIB), Sorbonne University, CNRS, INSERM, Paris, FranceDepartment of Neurology, Pitié-Salpêtrière University Hospital (APHP), Paris, FranceAmyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease with no effective disease modifying therapies at present. Spinal cord degeneration is a hallmark feature of ALS, highlighted in the earliest descriptions of the disease by Lockhart Clarke and Jean-Martin Charcot. The anterior horns and corticospinal tracts are invariably affected in ALS, but up to recently it has been notoriously challenging to detect and characterize spinal pathology in vivo. With recent technological advances, spinal imaging now offers unique opportunities to appraise lower motor neuron degeneration, sensory involvement, metabolic alterations, and interneuron pathology in ALS. Quantitative spinal imaging in ALS has now been used in cross-sectional and longitudinal study designs, applied to presymptomatic mutation carriers, and utilized in machine learning applications. Despite its enormous clinical and academic potential, a number of physiological, technological, and methodological challenges limit the routine use of computational spinal imaging in ALS. In this review, we provide a comprehensive overview of emerging spinal cord imaging methods and discuss their advantages, drawbacks, and biomarker potential in clinical applications, clinical trial settings, monitoring, and prognostic roles.https://www.frontiersin.org/article/10.3389/fneur.2019.00350/fullALS (Amyotrophic lateral sclerosis)MRI—magnetic resonance imagingMNDspinal cordneuroimaging |
| spellingShingle | Mohamed Mounir El Mendili Mohamed Mounir El Mendili Giorgia Querin Giorgia Querin Peter Bede Peter Bede Peter Bede Pierre-François Pradat Pierre-François Pradat Spinal Cord Imaging in Amyotrophic Lateral Sclerosis: Historical Concepts—Novel Techniques Frontiers in Neurology ALS (Amyotrophic lateral sclerosis) MRI—magnetic resonance imaging MND spinal cord neuroimaging |
| title | Spinal Cord Imaging in Amyotrophic Lateral Sclerosis: Historical Concepts—Novel Techniques |
| title_full | Spinal Cord Imaging in Amyotrophic Lateral Sclerosis: Historical Concepts—Novel Techniques |
| title_fullStr | Spinal Cord Imaging in Amyotrophic Lateral Sclerosis: Historical Concepts—Novel Techniques |
| title_full_unstemmed | Spinal Cord Imaging in Amyotrophic Lateral Sclerosis: Historical Concepts—Novel Techniques |
| title_short | Spinal Cord Imaging in Amyotrophic Lateral Sclerosis: Historical Concepts—Novel Techniques |
| title_sort | spinal cord imaging in amyotrophic lateral sclerosis historical concepts novel techniques |
| topic | ALS (Amyotrophic lateral sclerosis) MRI—magnetic resonance imaging MND spinal cord neuroimaging |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.00350/full |
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