Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life
Membrane proteins can be classified into two main categories—integral and peripheral membrane proteins—depending on the nature of their membrane interaction. Peripheral membrane proteins are highly unique amphipathic proteins that interact with the membrane indirectly, using electrostatic or hydroph...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Membranes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0375/11/5/346 |
| _version_ | 1797534898117935104 |
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| author | Deborah M. Boes Albert Godoy-Hernandez Duncan G. G. McMillan |
| author_facet | Deborah M. Boes Albert Godoy-Hernandez Duncan G. G. McMillan |
| author_sort | Deborah M. Boes |
| collection | DOAJ |
| description | Membrane proteins can be classified into two main categories—integral and peripheral membrane proteins—depending on the nature of their membrane interaction. Peripheral membrane proteins are highly unique amphipathic proteins that interact with the membrane indirectly, using electrostatic or hydrophobic interactions, or directly, using hydrophobic tails or GPI-anchors. The nature of this interaction not only influences the location of the protein in the cell, but also the function. In addition to their unique relationship with the cell membrane, peripheral membrane proteins often play a key role in the development of human diseases such as African sleeping sickness, cancer, and atherosclerosis. This review will discuss the membrane interaction and role of periplasmic nitrate reductase, CymA, cytochrome <i>c,</i> alkaline phosphatase, ecto-5’-nucleotidase, acetylcholinesterase, alternative oxidase, type-II NADH dehydrogenase, and dihydroorotate dehydrogenase in certain diseases. The study of these proteins will give new insights into their function and structure, and may ultimately lead to ground-breaking advances in the treatment of severe diseases. |
| first_indexed | 2024-03-10T11:36:58Z |
| format | Article |
| id | doaj.art-d81dadf7d97e46a99ea807fb52c283bd |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-10T11:36:58Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-d81dadf7d97e46a99ea807fb52c283bd2023-11-21T18:51:24ZengMDPI AGMembranes2077-03752021-05-0111534610.3390/membranes11050346Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of LifeDeborah M. Boes0Albert Godoy-Hernandez1Duncan G. G. McMillan2Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, NL-2629 HZ Delft, The NetherlandsDepartment of Biotechnology, Delft University of Technology, Van der Maasweg 9, NL-2629 HZ Delft, The NetherlandsDepartment of Biotechnology, Delft University of Technology, Van der Maasweg 9, NL-2629 HZ Delft, The NetherlandsMembrane proteins can be classified into two main categories—integral and peripheral membrane proteins—depending on the nature of their membrane interaction. Peripheral membrane proteins are highly unique amphipathic proteins that interact with the membrane indirectly, using electrostatic or hydrophobic interactions, or directly, using hydrophobic tails or GPI-anchors. The nature of this interaction not only influences the location of the protein in the cell, but also the function. In addition to their unique relationship with the cell membrane, peripheral membrane proteins often play a key role in the development of human diseases such as African sleeping sickness, cancer, and atherosclerosis. This review will discuss the membrane interaction and role of periplasmic nitrate reductase, CymA, cytochrome <i>c,</i> alkaline phosphatase, ecto-5’-nucleotidase, acetylcholinesterase, alternative oxidase, type-II NADH dehydrogenase, and dihydroorotate dehydrogenase in certain diseases. The study of these proteins will give new insights into their function and structure, and may ultimately lead to ground-breaking advances in the treatment of severe diseases.https://www.mdpi.com/2077-0375/11/5/346peripheral membrane proteinshuman diseasesGPI-anchored proteinselectrostatic interactionshydrophobic membrane anchordrug targets |
| spellingShingle | Deborah M. Boes Albert Godoy-Hernandez Duncan G. G. McMillan Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life Membranes peripheral membrane proteins human diseases GPI-anchored proteins electrostatic interactions hydrophobic membrane anchor drug targets |
| title | Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life |
| title_full | Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life |
| title_fullStr | Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life |
| title_full_unstemmed | Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life |
| title_short | Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life |
| title_sort | peripheral membrane proteins promising therapeutic targets across domains of life |
| topic | peripheral membrane proteins human diseases GPI-anchored proteins electrostatic interactions hydrophobic membrane anchor drug targets |
| url | https://www.mdpi.com/2077-0375/11/5/346 |
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