The role of zinc supplementation in humoral immune response to hepatitis B vaccination in infants: a double-blind randomized placebo-controlled trial
Background Suboptimal zinc intake may depress thymus function, lymphoproliferation, and T cell-dependent B-cell proliferation, which can impair antibody production. Zinc supplementation can improve immune function and reduce morbidity. Objective To assess the effect of zinc supplementation on infant...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2016-09-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/632 |
| _version_ | 1818994833338925056 |
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| author | K. Suarca Hendra S B. N. P. Arhana I K. G. Suandi |
| author_facet | K. Suarca Hendra S B. N. P. Arhana I K. G. Suandi |
| author_sort | K. Suarca |
| collection | DOAJ |
| description | Background Suboptimal zinc intake may depress thymus function,
lymphoproliferation, and T cell-dependent B-cell proliferation,
which can impair antibody production. Zinc supplementation can
improve immune function and reduce morbidity.
Objective To assess the effect of zinc supplementation on infants'
anti-HBs titer after hepatitis B vaccination.
Methods A double-blind randomized control trial of 66 healthy
infants in Pustu Dauh Puri, Denpasar Barat was conducted. Subjects
were followed from birth to three months of age and were placed
into two treatment groups using block randomization. One group
received zinc supplements with a standard hepatitis B vaccination
(zinc group, n=33) and the other group received placebo
supplements with standard hepatitis B vaccination (placebo group,
n=33). The serum zinc levels were measured at baseline and at
three months. The difference in levels of anti-HBs titer between the
zinc and placebo groups was the primary endpoint of this study.
Results The serum zinc levels were significantly higher in the zinc
group compared to the placebo group (P = 0.017), with a mean
difference of 18.76 miU/ml (95% CI 3.45 to 34.07). Regardless
of baseline serum zinc levels, the mean anti-HBs titers were
significantly higher in the zinc group compared to the placebo
group (P <0.0001; mean difference = 495.8 miU/mL; 95%
CI 362.32 to 629.44). Multivariate analysis showed that zinc
supplementation was the only variable that influenced anti-HBs
titer levels (P < 0.0001).
Conclusion Regardless of their initial zinc serum level, infants
receiving zinc supplements along with standard hepatitis B
vaccination have significantly higher levels of anti-HBs titers
than infants receiving hepatitis B vaccination without zinc
supplements. |
| first_indexed | 2024-12-20T21:04:14Z |
| format | Article |
| id | doaj.art-d81e10f9d7764746ba4f8ac334425bbd |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-20T21:04:14Z |
| publishDate | 2016-09-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-d81e10f9d7764746ba4f8ac334425bbd2022-12-21T19:26:38ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2016-09-014863748010.14238/pi48.6.2008.374-80503The role of zinc supplementation in humoral immune response to hepatitis B vaccination in infants: a double-blind randomized placebo-controlled trialK. SuarcaHendra SB. N. P. ArhanaI K. G. SuandiBackground Suboptimal zinc intake may depress thymus function, lymphoproliferation, and T cell-dependent B-cell proliferation, which can impair antibody production. Zinc supplementation can improve immune function and reduce morbidity. Objective To assess the effect of zinc supplementation on infants' anti-HBs titer after hepatitis B vaccination. Methods A double-blind randomized control trial of 66 healthy infants in Pustu Dauh Puri, Denpasar Barat was conducted. Subjects were followed from birth to three months of age and were placed into two treatment groups using block randomization. One group received zinc supplements with a standard hepatitis B vaccination (zinc group, n=33) and the other group received placebo supplements with standard hepatitis B vaccination (placebo group, n=33). The serum zinc levels were measured at baseline and at three months. The difference in levels of anti-HBs titer between the zinc and placebo groups was the primary endpoint of this study. Results The serum zinc levels were significantly higher in the zinc group compared to the placebo group (P = 0.017), with a mean difference of 18.76 miU/ml (95% CI 3.45 to 34.07). Regardless of baseline serum zinc levels, the mean anti-HBs titers were significantly higher in the zinc group compared to the placebo group (P <0.0001; mean difference = 495.8 miU/mL; 95% CI 362.32 to 629.44). Multivariate analysis showed that zinc supplementation was the only variable that influenced anti-HBs titer levels (P < 0.0001). Conclusion Regardless of their initial zinc serum level, infants receiving zinc supplements along with standard hepatitis B vaccination have significantly higher levels of anti-HBs titers than infants receiving hepatitis B vaccination without zinc supplements.https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/632zinc supplementationserum zinc levelhepatitis B vaccinationanti-HBs titer |
| spellingShingle | K. Suarca Hendra S B. N. P. Arhana I K. G. Suandi The role of zinc supplementation in humoral immune response to hepatitis B vaccination in infants: a double-blind randomized placebo-controlled trial Paediatrica Indonesiana zinc supplementation serum zinc level hepatitis B vaccination anti-HBs titer |
| title | The role of zinc supplementation in humoral immune response to hepatitis B vaccination in infants: a double-blind randomized placebo-controlled trial |
| title_full | The role of zinc supplementation in humoral immune response to hepatitis B vaccination in infants: a double-blind randomized placebo-controlled trial |
| title_fullStr | The role of zinc supplementation in humoral immune response to hepatitis B vaccination in infants: a double-blind randomized placebo-controlled trial |
| title_full_unstemmed | The role of zinc supplementation in humoral immune response to hepatitis B vaccination in infants: a double-blind randomized placebo-controlled trial |
| title_short | The role of zinc supplementation in humoral immune response to hepatitis B vaccination in infants: a double-blind randomized placebo-controlled trial |
| title_sort | role of zinc supplementation in humoral immune response to hepatitis b vaccination in infants a double blind randomized placebo controlled trial |
| topic | zinc supplementation serum zinc level hepatitis B vaccination anti-HBs titer |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/632 |
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