Ursodeoxycholic acid for the prevention of symptomatic gallstone disease after bariatric surgery: statistical analysis plan for a randomised controlled trial (UPGRADE trial)

Ursodeoxycholic acid for the prevention of symptomatic gallstone disease after bariatric surgery: statistical analysis plan for a randomised controlled trial (UPGRADE trial)

Abstract Background Approximately 8–15% of patients undergoing bariatric surgery develop symptomatic gallstone disease within 24 months after surgery. Ursodeoxycholic acid (UDCA) seems to effectively prevent the formation of gallstones detectable by ultrasound after bariatric surgery. The aim of the...

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Bibliographic Details
Main Authors: Sylke Haal, Maimoena S. S. Guman, L. Maurits de Brauw, Ruben N. van Veen, Ruben Schouten, Paul Fockens, Victor E. A. Gerdes, Marcel G. W. Dijkgraaf, Rogier P. Voermans
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Trials
Subjects:
Bariatric surgery
Symptomatic gallstone disease
Ursodeoxycholic acid
Randomised controlled trial
Statistical analysis plan
Online Access:http://link.springer.com/article/10.1186/s13063-020-04605-7

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