<i>Drosophila</i> Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders
Glial cells are key players in the proper formation and maintenance of the nervous system, thus contributing to neuronal health and disease in humans. However, little is known about the molecular pathways that govern glia–neuron communications in the diseased brain. <i>Drosophila</i> pro...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/14/4859 |
| _version_ | 1797562957982334976 |
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| author | Taejoon Kim Bokyeong Song Im-Soon Lee |
| author_facet | Taejoon Kim Bokyeong Song Im-Soon Lee |
| author_sort | Taejoon Kim |
| collection | DOAJ |
| description | Glial cells are key players in the proper formation and maintenance of the nervous system, thus contributing to neuronal health and disease in humans. However, little is known about the molecular pathways that govern glia–neuron communications in the diseased brain. <i>Drosophila</i> provides a useful in vivo model to explore the conserved molecular details of glial cell biology and their contributions to brain function and disease susceptibility. Herein, we review recent studies that explore glial functions in normal neuronal development, along with <i>Drosophila</i> models that seek to identify the pathological implications of glial defects in the context of various central nervous system disorders. |
| first_indexed | 2024-03-10T18:35:58Z |
| format | Article |
| id | doaj.art-d81efebaebb64de1a5e1618290988042 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:35:58Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d81efebaebb64de1a5e16182909880422023-11-20T06:18:24ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-012114485910.3390/ijms21144859<i>Drosophila</i> Glia: Models for Human Neurodevelopmental and Neurodegenerative DisordersTaejoon Kim0Bokyeong Song1Im-Soon Lee2Department of Biological Sciences, Center for CHANS, Konkuk University, Seoul 05029, KoreaDepartment of Biological Sciences, Center for CHANS, Konkuk University, Seoul 05029, KoreaDepartment of Biological Sciences, Center for CHANS, Konkuk University, Seoul 05029, KoreaGlial cells are key players in the proper formation and maintenance of the nervous system, thus contributing to neuronal health and disease in humans. However, little is known about the molecular pathways that govern glia–neuron communications in the diseased brain. <i>Drosophila</i> provides a useful in vivo model to explore the conserved molecular details of glial cell biology and their contributions to brain function and disease susceptibility. Herein, we review recent studies that explore glial functions in normal neuronal development, along with <i>Drosophila</i> models that seek to identify the pathological implications of glial defects in the context of various central nervous system disorders.https://www.mdpi.com/1422-0067/21/14/4859gliaglial defects<i>Drosophila</i> modelsCNS disorders |
| spellingShingle | Taejoon Kim Bokyeong Song Im-Soon Lee <i>Drosophila</i> Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders International Journal of Molecular Sciences glia glial defects <i>Drosophila</i> models CNS disorders |
| title | <i>Drosophila</i> Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders |
| title_full | <i>Drosophila</i> Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders |
| title_fullStr | <i>Drosophila</i> Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders |
| title_full_unstemmed | <i>Drosophila</i> Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders |
| title_short | <i>Drosophila</i> Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders |
| title_sort | i drosophila i glia models for human neurodevelopmental and neurodegenerative disorders |
| topic | glia glial defects <i>Drosophila</i> models CNS disorders |
| url | https://www.mdpi.com/1422-0067/21/14/4859 |
| work_keys_str_mv | AT taejoonkim idrosophilaigliamodelsforhumanneurodevelopmentalandneurodegenerativedisorders AT bokyeongsong idrosophilaigliamodelsforhumanneurodevelopmentalandneurodegenerativedisorders AT imsoonlee idrosophilaigliamodelsforhumanneurodevelopmentalandneurodegenerativedisorders |