Phage Adsorption to Gram-Positive Bacteria
The phage life cycle is a multi-stage process initiated by the recognition and attachment of the virus to its bacterial host. This adsorption step depends on the specific interaction between bacterial structures acting as receptors and viral proteins called Receptor Binding Proteins (RBP). The adsor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/1/196 |
| _version_ | 1797436432793468928 |
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| author | Audrey Leprince Jacques Mahillon |
| author_facet | Audrey Leprince Jacques Mahillon |
| author_sort | Audrey Leprince |
| collection | DOAJ |
| description | The phage life cycle is a multi-stage process initiated by the recognition and attachment of the virus to its bacterial host. This adsorption step depends on the specific interaction between bacterial structures acting as receptors and viral proteins called Receptor Binding Proteins (RBP). The adsorption process is essential as it is the first determinant of phage host range and a sine qua non condition for the subsequent conduct of the life cycle. In phages belonging to the <i>Caudoviricetes</i> class, the capsid is attached to a tail, which is the central player in the adsorption as it comprises the RBP and accessory proteins facilitating phage binding and cell wall penetration prior to genome injection. The nature of the viral proteins involved in host adhesion not only depends on the phage morphology (i.e., myovirus, siphovirus, or podovirus) but also the targeted host. Here, we give an overview of the adsorption process and compile the available information on the type of receptors that can be recognized and the viral proteins taking part in the process, with the primary focus on phages infecting Gram-positive bacteria. |
| first_indexed | 2024-03-09T11:02:36Z |
| format | Article |
| id | doaj.art-d8217311b73a4120aacf30e00bfd880a |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T11:02:36Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-d8217311b73a4120aacf30e00bfd880a2023-12-01T01:12:37ZengMDPI AGViruses1999-49152023-01-0115119610.3390/v15010196Phage Adsorption to Gram-Positive BacteriaAudrey Leprince0Jacques Mahillon1Laboratory of Food and Environmental Microbiology, Earth and Life Institute, UCLouvain, 1348 Louvain-la-Neuve, BelgiumLaboratory of Food and Environmental Microbiology, Earth and Life Institute, UCLouvain, 1348 Louvain-la-Neuve, BelgiumThe phage life cycle is a multi-stage process initiated by the recognition and attachment of the virus to its bacterial host. This adsorption step depends on the specific interaction between bacterial structures acting as receptors and viral proteins called Receptor Binding Proteins (RBP). The adsorption process is essential as it is the first determinant of phage host range and a sine qua non condition for the subsequent conduct of the life cycle. In phages belonging to the <i>Caudoviricetes</i> class, the capsid is attached to a tail, which is the central player in the adsorption as it comprises the RBP and accessory proteins facilitating phage binding and cell wall penetration prior to genome injection. The nature of the viral proteins involved in host adhesion not only depends on the phage morphology (i.e., myovirus, siphovirus, or podovirus) but also the targeted host. Here, we give an overview of the adsorption process and compile the available information on the type of receptors that can be recognized and the viral proteins taking part in the process, with the primary focus on phages infecting Gram-positive bacteria.https://www.mdpi.com/1999-4915/15/1/196phagereceptorreceptor binding proteinadsorptiontailGram-positive host |
| spellingShingle | Audrey Leprince Jacques Mahillon Phage Adsorption to Gram-Positive Bacteria Viruses phage receptor receptor binding protein adsorption tail Gram-positive host |
| title | Phage Adsorption to Gram-Positive Bacteria |
| title_full | Phage Adsorption to Gram-Positive Bacteria |
| title_fullStr | Phage Adsorption to Gram-Positive Bacteria |
| title_full_unstemmed | Phage Adsorption to Gram-Positive Bacteria |
| title_short | Phage Adsorption to Gram-Positive Bacteria |
| title_sort | phage adsorption to gram positive bacteria |
| topic | phage receptor receptor binding protein adsorption tail Gram-positive host |
| url | https://www.mdpi.com/1999-4915/15/1/196 |
| work_keys_str_mv | AT audreyleprince phageadsorptiontogrampositivebacteria AT jacquesmahillon phageadsorptiontogrampositivebacteria |