Theaflavin-3, 3′-Digallate Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Ovariectomy-Induced Bone Loss in Mice

Theaflavin-3, 3′-Digallate Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Ovariectomy-Induced Bone Loss in Mice

Theaflavin-3, 3′-digallate (TF3) is extracted from black tea and has strong antioxidant capabilities. The aim of this study was to assess the influences of TF3 on osteoclastogenesis and explore the underlying mechanisms. TF3 efficiently decreased receptor activator of nuclear factor-kappa B ligand (...

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Bibliographic Details
Main Authors: Zexin Ai, Yang’ou Wu, Miao Yu, Jia Li, Shengjiao Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
theaflavin-3,3′-digallate
osteoclast
reactive oxygen species
Nrf2
osteoporosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00803/full

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