Bioanalytical Method Development and Validation of Veratraldehyde and Its Metabolite Veratric Acid in Rat Plasma: An Application for a Pharmacokinetic Study

Bioanalytical Method Development and Validation of Veratraldehyde and Its Metabolite Veratric Acid in Rat Plasma: An Application for a Pharmacokinetic Study

A simple, sensitive, and rapid UHPLC-MS/MS method was developed for the simultaneous determination of veratraldehyde and its metabolite veratric acid in rat plasma. Cinnamaldehyde was used as an internal standard (IS) and the one-step protein precipitation method with 0.2% formic acid in acetonitril...

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Bibliographic Details
Main Authors: Hyun Wook Huh, Hee-Yong Song, Young-Guk Na, Minki Kim, Mingu Han, Thi Mai Anh Pham, Hyeonmin Lee, Jungkyu Suh, Seok-Jong Lee, Hong-Ki Lee, Cheong-Weon Cho
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Molecules
Subjects:
veratraldehyde
veratric acid
bioanalytical method
UHPLC
triple quadrupole mass spectrometer
pharmacokinetics
Online Access:https://www.mdpi.com/1420-3049/25/12/2800

Internet

https://www.mdpi.com/1420-3049/25/12/2800

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