Targeting to brain tumor: Nanocarrier-based drug delivery platforms, opportunities, and challenges
Cancer is a class of disorder characterized by anomalous growth of cells escalating in an uncontrolled way. Among all the cancers, treatment of cancerous brain tumors has been a tough challenge for the research scientists. Moreover, the absence of early-stage symptoms delays its diagnosis, consequen...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=2;spage=172;epage=177;aulast=Kumar |
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| author | Ladi Alik Kumar Gurudutta Pattnaik Bhabani Sankar Satapathy S Swapna Dibyalochan Mohanty |
| author_facet | Ladi Alik Kumar Gurudutta Pattnaik Bhabani Sankar Satapathy S Swapna Dibyalochan Mohanty |
| author_sort | Ladi Alik Kumar |
| collection | DOAJ |
| description | Cancer is a class of disorder characterized by anomalous growth of cells escalating in an uncontrolled way. Among all the cancers, treatment of cancerous brain tumors has been a tough challenge for the research scientists. Moreover, the absence of early-stage symptoms delays its diagnosis, consequently worsening its severity. Conventional treatments such as surgery, radiation, and chemotherapy are still linked with several limitations. The therapeutic effect of most of the anticancer drugs is highly restricted by their inability to pass the blood–brain barrier, low solubility, limited therapeutic window, and so on. Alarming incidences of brain cases associated with low survival rate across the globe coupled with the inefficiency of current treatment strategies have forced the formulation scientists to investigate nanotechnology-based advanced therapeutic approaches to tackle the disease. Various nanoplatforms such as polymeric nanoparticles (NPs), nanoliposomes, dendrimers, carbon nanotubes, and magnetic NPs have been reported in the past years to improve the drug administration into brain tumor cells and to minimize their off-target distribution for lesser side effects and better treatment outcomes. The review presents updated information on the nanocarrier-based drug delivery systems reported in the past few years for the treatment of brain tumor along with new advancements in this field. It also throws some light on the recent challenges faced in the practical field for the successful clinical translation of such nanodrug carriers along with a discussion on the future prospects. |
| first_indexed | 2024-12-22T01:57:36Z |
| format | Article |
| id | doaj.art-d82d202384cb4156bfc7530a2ff99501 |
| institution | Directory Open Access Journal |
| issn | 0975-7406 |
| language | English |
| last_indexed | 2024-12-22T01:57:36Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-d82d202384cb4156bfc7530a2ff995012022-12-21T18:42:44ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74062021-01-0113217217710.4103/jpbs.JPBS_239_20Targeting to brain tumor: Nanocarrier-based drug delivery platforms, opportunities, and challengesLadi Alik KumarGurudutta PattnaikBhabani Sankar SatapathyS SwapnaDibyalochan MohantyCancer is a class of disorder characterized by anomalous growth of cells escalating in an uncontrolled way. Among all the cancers, treatment of cancerous brain tumors has been a tough challenge for the research scientists. Moreover, the absence of early-stage symptoms delays its diagnosis, consequently worsening its severity. Conventional treatments such as surgery, radiation, and chemotherapy are still linked with several limitations. The therapeutic effect of most of the anticancer drugs is highly restricted by their inability to pass the blood–brain barrier, low solubility, limited therapeutic window, and so on. Alarming incidences of brain cases associated with low survival rate across the globe coupled with the inefficiency of current treatment strategies have forced the formulation scientists to investigate nanotechnology-based advanced therapeutic approaches to tackle the disease. Various nanoplatforms such as polymeric nanoparticles (NPs), nanoliposomes, dendrimers, carbon nanotubes, and magnetic NPs have been reported in the past years to improve the drug administration into brain tumor cells and to minimize their off-target distribution for lesser side effects and better treatment outcomes. The review presents updated information on the nanocarrier-based drug delivery systems reported in the past few years for the treatment of brain tumor along with new advancements in this field. It also throws some light on the recent challenges faced in the practical field for the successful clinical translation of such nanodrug carriers along with a discussion on the future prospects.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=2;spage=172;epage=177;aulast=Kumarblood brain barrierbrain tumorchallengesnanocarrierstargeting |
| spellingShingle | Ladi Alik Kumar Gurudutta Pattnaik Bhabani Sankar Satapathy S Swapna Dibyalochan Mohanty Targeting to brain tumor: Nanocarrier-based drug delivery platforms, opportunities, and challenges Journal of Pharmacy and Bioallied Sciences blood brain barrier brain tumor challenges nanocarriers targeting |
| title | Targeting to brain tumor: Nanocarrier-based drug delivery platforms, opportunities, and challenges |
| title_full | Targeting to brain tumor: Nanocarrier-based drug delivery platforms, opportunities, and challenges |
| title_fullStr | Targeting to brain tumor: Nanocarrier-based drug delivery platforms, opportunities, and challenges |
| title_full_unstemmed | Targeting to brain tumor: Nanocarrier-based drug delivery platforms, opportunities, and challenges |
| title_short | Targeting to brain tumor: Nanocarrier-based drug delivery platforms, opportunities, and challenges |
| title_sort | targeting to brain tumor nanocarrier based drug delivery platforms opportunities and challenges |
| topic | blood brain barrier brain tumor challenges nanocarriers targeting |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=2;spage=172;epage=177;aulast=Kumar |
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