The Role of Epac in Cancer Progression
Cancer continues to be a prime contributor to global mortality. Despite tremendous research efforts and major advances in cancer therapy, much remains to be learned about the underlying molecular mechanisms of this debilitating disease. A better understanding of the key signaling events driving the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/18/6489 |
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| author | Nadine Wehbe Hasan Slika Joelle Mesmar Suzanne A. Nasser Gianfranco Pintus Serine Baydoun Adnan Badran Firas Kobeissy Ali H. Eid Elias Baydoun |
| author_facet | Nadine Wehbe Hasan Slika Joelle Mesmar Suzanne A. Nasser Gianfranco Pintus Serine Baydoun Adnan Badran Firas Kobeissy Ali H. Eid Elias Baydoun |
| author_sort | Nadine Wehbe |
| collection | DOAJ |
| description | Cancer continues to be a prime contributor to global mortality. Despite tremendous research efforts and major advances in cancer therapy, much remains to be learned about the underlying molecular mechanisms of this debilitating disease. A better understanding of the key signaling events driving the malignant phenotype of cancer cells may help identify new pharmaco-targets. Cyclic adenosine 3′,5′-monophosphate (cAMP) modulates a plethora of biological processes, including those that are characteristic of malignant cells. Over the years, most cAMP-mediated actions were attributed to the activity of its effector protein kinase A (PKA). However, studies have revealed an important role for the exchange protein activated by cAMP (Epac) as another effector mediating the actions of cAMP. In cancer, Epac appears to have a dual role in regulating cellular processes that are essential for carcinogenesis. In addition, the development of Epac modulators offered new routes to further explore the role of this cAMP effector and its downstream pathways in cancer. In this review, the potentials of Epac as an attractive target in the fight against cancer are depicted. Additionally, the role of Epac in cancer progression, namely its effect on cancer cell proliferation, migration/metastasis, and apoptosis, with the possible interaction of reactive oxygen species (ROS) in these phenomena, is discussed with emphasis on the underlying mechanisms and pathways. |
| first_indexed | 2024-03-10T16:33:17Z |
| format | Article |
| id | doaj.art-d82d4678205f4ae09e6a40c6acc8fe10 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:33:17Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d82d4678205f4ae09e6a40c6acc8fe102023-11-20T12:40:40ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012118648910.3390/ijms21186489The Role of Epac in Cancer ProgressionNadine Wehbe0Hasan Slika1Joelle Mesmar2Suzanne A. Nasser3Gianfranco Pintus4Serine Baydoun5Adnan Badran6Firas Kobeissy7Ali H. Eid8Elias Baydoun9Department of Biology, American University of Beirut, P.O. Box 11-0236 Beirut, LebanonDepartment of Pharmacology and Therapeutics, Faculty of Medicine, American University of Beirut, P.O. Box 11-0236 Beirut, LebanonDepartment of Biology, American University of Beirut, P.O. Box 11-0236 Beirut, LebanonDepartment of Pharmacology, Beirut Arab University, P.O. Box 11-5020 Beirut, LebanonDepartment of Biomedical Sciences, University of Sharjah, P.O. Box 27272 Sharjah, UAEDepartment of Radiology, American University of Beirut, P.O. Box 11-0236 Beirut, LebanonDepartment of Basic Sciences, University of Petra, P.O. Box 961343, Amman 11196, JordanDepartment of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, P.O. Box 11-0236, Beirut, LebanonDepartment of Pharmacology and Therapeutics, Faculty of Medicine, American University of Beirut, P.O. Box 11-0236 Beirut, LebanonDepartment of Biology, American University of Beirut, P.O. Box 11-0236 Beirut, LebanonCancer continues to be a prime contributor to global mortality. Despite tremendous research efforts and major advances in cancer therapy, much remains to be learned about the underlying molecular mechanisms of this debilitating disease. A better understanding of the key signaling events driving the malignant phenotype of cancer cells may help identify new pharmaco-targets. Cyclic adenosine 3′,5′-monophosphate (cAMP) modulates a plethora of biological processes, including those that are characteristic of malignant cells. Over the years, most cAMP-mediated actions were attributed to the activity of its effector protein kinase A (PKA). However, studies have revealed an important role for the exchange protein activated by cAMP (Epac) as another effector mediating the actions of cAMP. In cancer, Epac appears to have a dual role in regulating cellular processes that are essential for carcinogenesis. In addition, the development of Epac modulators offered new routes to further explore the role of this cAMP effector and its downstream pathways in cancer. In this review, the potentials of Epac as an attractive target in the fight against cancer are depicted. Additionally, the role of Epac in cancer progression, namely its effect on cancer cell proliferation, migration/metastasis, and apoptosis, with the possible interaction of reactive oxygen species (ROS) in these phenomena, is discussed with emphasis on the underlying mechanisms and pathways.https://www.mdpi.com/1422-0067/21/18/6489Epaccancerreactive oxygen species (ROS)cAMPPKA |
| spellingShingle | Nadine Wehbe Hasan Slika Joelle Mesmar Suzanne A. Nasser Gianfranco Pintus Serine Baydoun Adnan Badran Firas Kobeissy Ali H. Eid Elias Baydoun The Role of Epac in Cancer Progression International Journal of Molecular Sciences Epac cancer reactive oxygen species (ROS) cAMP PKA |
| title | The Role of Epac in Cancer Progression |
| title_full | The Role of Epac in Cancer Progression |
| title_fullStr | The Role of Epac in Cancer Progression |
| title_full_unstemmed | The Role of Epac in Cancer Progression |
| title_short | The Role of Epac in Cancer Progression |
| title_sort | role of epac in cancer progression |
| topic | Epac cancer reactive oxygen species (ROS) cAMP PKA |
| url | https://www.mdpi.com/1422-0067/21/18/6489 |
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