A New Insight on the Radioprotective Potential of Epsilon-Aminocaproic Acid
<i>Background and objectives:</i> The aim of the study was to scrutinize the ability of epsilon-aminocaproic acid (EACA) to prevent radiation-induced damage to human cells. <i>Materials and Methods:</i> Human peripheral blood mononuclear cells (PBMCs) were exposed to ionizing...
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| Format: | Article |
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MDPI AG
2020-11-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/56/12/663 |
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| author | Timur Saliev Dinara Baiskhanova Dmitriy Beznosko Dinara Begimbetova Bauyrzhan Umbayev Talgat Nurgozhin Ildar Fakhradiyev Baimakhan Tanabayev Dainius Pavalkis |
| author_facet | Timur Saliev Dinara Baiskhanova Dmitriy Beznosko Dinara Begimbetova Bauyrzhan Umbayev Talgat Nurgozhin Ildar Fakhradiyev Baimakhan Tanabayev Dainius Pavalkis |
| author_sort | Timur Saliev |
| collection | DOAJ |
| description | <i>Background and objectives:</i> The aim of the study was to scrutinize the ability of epsilon-aminocaproic acid (EACA) to prevent radiation-induced damage to human cells. <i>Materials and Methods:</i> Human peripheral blood mononuclear cells (PBMCs) were exposed to ionizing radiation at three low doses (22.62 mGy, 45.27 mGy, and 67.88 mGy) in the presence of EACA at the concentration of 50 ng/mL. <i>Results:</i> EACA was able to prevent cell death induced by low-dose X-ray radiation and suppress the formation of reactive oxygen species (ROS). EACA also demonstrated a capacity to protect DNA from radiation-induced damage. The data indicated that EACA is capable of suppression of radiation-induced apoptosis. Comparative tests of antioxidative activity of EACA and a range of free radical scavengers showed an ability of EACA to effectively inhibit the generation of ROS. <i>Conclusions:</i> This study showed that the pretreatment of PBMCs with EACA is able to protect the cells from radiation-elicited damage, including free radicals’ formation, DNA damage, and apoptosis. |
| first_indexed | 2024-03-12T09:52:43Z |
| format | Article |
| id | doaj.art-d82d9e6ce22645b7a1f44feef8de5a23 |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T09:52:43Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-d82d9e6ce22645b7a1f44feef8de5a232023-09-02T12:24:56ZengMDPI AGMedicina1010-660X2020-11-015666366310.3390/medicina56120663A New Insight on the Radioprotective Potential of Epsilon-Aminocaproic AcidTimur Saliev0Dinara Baiskhanova1Dmitriy Beznosko2Dinara Begimbetova3Bauyrzhan Umbayev4Talgat Nurgozhin5Ildar Fakhradiyev6Baimakhan Tanabayev7Dainius Pavalkis8S.D. Asfendiyarov Kazakh National Medical University, Almaty 050000, KazakhstanNational Laboratory Astana, Nazarbayev University, Nur-Sultan 010000, KazakhstanClayton State University, Morrow, GA 30260, USANational Laboratory Astana, Nazarbayev University, Nur-Sultan 010000, KazakhstanNational Laboratory Astana, Nazarbayev University, Nur-Sultan 010000, KazakhstanS.D. Asfendiyarov Kazakh National Medical University, Almaty 050000, KazakhstanS.D. Asfendiyarov Kazakh National Medical University, Almaty 050000, KazakhstanSouth-Kazakhstan Medical Academy, Shymkent 160012, KazakhstanNJSC “Astana Medical University”, Nur-sultan 010000, Kazakhstan<i>Background and objectives:</i> The aim of the study was to scrutinize the ability of epsilon-aminocaproic acid (EACA) to prevent radiation-induced damage to human cells. <i>Materials and Methods:</i> Human peripheral blood mononuclear cells (PBMCs) were exposed to ionizing radiation at three low doses (22.62 mGy, 45.27 mGy, and 67.88 mGy) in the presence of EACA at the concentration of 50 ng/mL. <i>Results:</i> EACA was able to prevent cell death induced by low-dose X-ray radiation and suppress the formation of reactive oxygen species (ROS). EACA also demonstrated a capacity to protect DNA from radiation-induced damage. The data indicated that EACA is capable of suppression of radiation-induced apoptosis. Comparative tests of antioxidative activity of EACA and a range of free radical scavengers showed an ability of EACA to effectively inhibit the generation of ROS. <i>Conclusions:</i> This study showed that the pretreatment of PBMCs with EACA is able to protect the cells from radiation-elicited damage, including free radicals’ formation, DNA damage, and apoptosis.https://www.mdpi.com/1010-660X/56/12/663radiationprotectionepsilon-aminocaproic acidDNA damagereactive oxygen speciesapoptosis |
| spellingShingle | Timur Saliev Dinara Baiskhanova Dmitriy Beznosko Dinara Begimbetova Bauyrzhan Umbayev Talgat Nurgozhin Ildar Fakhradiyev Baimakhan Tanabayev Dainius Pavalkis A New Insight on the Radioprotective Potential of Epsilon-Aminocaproic Acid Medicina radiation protection epsilon-aminocaproic acid DNA damage reactive oxygen species apoptosis |
| title | A New Insight on the Radioprotective Potential of Epsilon-Aminocaproic Acid |
| title_full | A New Insight on the Radioprotective Potential of Epsilon-Aminocaproic Acid |
| title_fullStr | A New Insight on the Radioprotective Potential of Epsilon-Aminocaproic Acid |
| title_full_unstemmed | A New Insight on the Radioprotective Potential of Epsilon-Aminocaproic Acid |
| title_short | A New Insight on the Radioprotective Potential of Epsilon-Aminocaproic Acid |
| title_sort | new insight on the radioprotective potential of epsilon aminocaproic acid |
| topic | radiation protection epsilon-aminocaproic acid DNA damage reactive oxygen species apoptosis |
| url | https://www.mdpi.com/1010-660X/56/12/663 |
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