Allosteric Inhibitors of Zika Virus NS2B-NS3 Protease Targeting Protease in “Super-Open” Conformation

Allosteric Inhibitors of Zika Virus NS2B-NS3 Protease Targeting Protease in “Super-Open” Conformation

The Zika virus (ZIKV), a member of the Flaviviridae family, is considered a major health threat causing multiple cases of microcephaly in newborns and Guillain-Barré syndrome in adults. In this study, we targeted a transient, deep, and hydrophobic pocket of the “super-open” conformation of ZIKV NS2B...

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Bibliographic Details
Main Authors: Ittipat Meewan, Sergey A. Shiryaev, Julius Kattoula, Chun-Teng Huang, Vivian Lin, Chiao-Han Chuang, Alexey V. Terskikh, Ruben Abagyan
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Viruses
Subjects:
Zika virus protease inhibitors
allosteric inhibitors
Zika virus NS2B-NS3 protease
super-open conformation
Online Access:https://www.mdpi.com/1999-4915/15/5/1106

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