Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomography
Abstract Background To investigate macular retinal and choroidal thickness in amblyopic eyes compared to that in fellow and normal eyes using swept-source optical coherence tomography (SS-OCT). Methods This study examined 31 patients with hyperopic anisometropic amblyopia (6.9 ± 3.8 years, mean ± st...
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| Format: | Article |
| Language: | English |
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BMC
2017-09-01
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| Series: | BMC Ophthalmology |
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| Online Access: | http://link.springer.com/article/10.1186/s12886-017-0559-3 |
| _version_ | 1819016242244091904 |
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| author | Syunsuke Araki Atsushi Miki Katsutoshi Goto Tsutomu Yamashita Go Takizawa Kazuko Haruishi Yoshiaki Ieki Junichi Kiryu Kiyoshi Yaoeda |
| author_facet | Syunsuke Araki Atsushi Miki Katsutoshi Goto Tsutomu Yamashita Go Takizawa Kazuko Haruishi Yoshiaki Ieki Junichi Kiryu Kiyoshi Yaoeda |
| author_sort | Syunsuke Araki |
| collection | DOAJ |
| description | Abstract Background To investigate macular retinal and choroidal thickness in amblyopic eyes compared to that in fellow and normal eyes using swept-source optical coherence tomography (SS-OCT). Methods This study examined 31 patients with hyperopic anisometropic amblyopia (6.9 ± 3.8 years, mean ± standard deviation), 15 patients with strabismic amblyopia without anisometropia (7.9 ± 4.2 years), and 24 age-matched controls (7.8 ± 3.3 years). Retinal and choroidal thickness was measured by 3D scans using SS-OCT. A 6-mm area around the fovea was automatically analyzed using the Early Treatment Diabetic Retinopathy Study map. The thickness from SS-OCT was corrected for magnification error using individual axial length, spherical refraction, cylinder refraction, and corneal radius. Retinal thickness was divided into the macular retinal nerve fiber layer (mRNFL), ganglion cell layer + inner plexiform layer (GCL+IPL), ganglion cell complex (GCC), and the inner limiting membrane to the retinal pigment epithelium (ILM-RPE) thickness. Retinal and choroidal thickness was compared among amblyopic, fellow, and normal eyes. Results In both amblyopia groups, there was no significant difference in the mRNFL, GCL+IPL, and GCC thicknesses among the amblyopic, fellow, and control eyes. In the anisometropic amblyopia group, choroidal thickness (subfovea, center 1 mm, nasal and inferior of the inner ring, nasal of the outer ring, and center 6 mm) of amblyopic eyes were significantly greater than that of fellow and normal eyes. In contrast, none of the choroidal thicknesses were significantly different among the investigated eyes in the strabismic amblyopia group. Conclusions We found no significant difference in inner retinal thickness in patients with unilateral amblyopia. Although there were significant differences in choroidal thickness with hyperopic anisometropic amblyopia, there was no significant difference for the strabismic amblyopia. The discrepancy in choroidal thickness between the two types of amblyopia may be due to both differences in ocular size and underlying mechanism. |
| first_indexed | 2024-12-21T02:44:31Z |
| format | Article |
| id | doaj.art-d82e2206d4854123bdbd86544b1b79f9 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-21T02:44:31Z |
| publishDate | 2017-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-d82e2206d4854123bdbd86544b1b79f92022-12-21T19:18:36ZengBMCBMC Ophthalmology1471-24152017-09-0117111310.1186/s12886-017-0559-3Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomographySyunsuke Araki0Atsushi Miki1Katsutoshi Goto2Tsutomu Yamashita3Go Takizawa4Kazuko Haruishi5Yoshiaki Ieki6Junichi Kiryu7Kiyoshi Yaoeda8Department of Ophthalmology, Kawasaki Medical SchoolDepartment of Ophthalmology, Kawasaki Medical SchoolDepartment of Ophthalmology, Kawasaki Medical SchoolDepartment of Ophthalmology, Kawasaki Medical SchoolDepartment of Ophthalmology, Kawasaki Medical SchoolDepartment of Ophthalmology, Kawasaki Medical SchoolDepartment of Ophthalmology, Kawasaki Medical SchoolDepartment of Ophthalmology, Kawasaki Medical SchoolYaoeda Eye ClinicAbstract Background To investigate macular retinal and choroidal thickness in amblyopic eyes compared to that in fellow and normal eyes using swept-source optical coherence tomography (SS-OCT). Methods This study examined 31 patients with hyperopic anisometropic amblyopia (6.9 ± 3.8 years, mean ± standard deviation), 15 patients with strabismic amblyopia without anisometropia (7.9 ± 4.2 years), and 24 age-matched controls (7.8 ± 3.3 years). Retinal and choroidal thickness was measured by 3D scans using SS-OCT. A 6-mm area around the fovea was automatically analyzed using the Early Treatment Diabetic Retinopathy Study map. The thickness from SS-OCT was corrected for magnification error using individual axial length, spherical refraction, cylinder refraction, and corneal radius. Retinal thickness was divided into the macular retinal nerve fiber layer (mRNFL), ganglion cell layer + inner plexiform layer (GCL+IPL), ganglion cell complex (GCC), and the inner limiting membrane to the retinal pigment epithelium (ILM-RPE) thickness. Retinal and choroidal thickness was compared among amblyopic, fellow, and normal eyes. Results In both amblyopia groups, there was no significant difference in the mRNFL, GCL+IPL, and GCC thicknesses among the amblyopic, fellow, and control eyes. In the anisometropic amblyopia group, choroidal thickness (subfovea, center 1 mm, nasal and inferior of the inner ring, nasal of the outer ring, and center 6 mm) of amblyopic eyes were significantly greater than that of fellow and normal eyes. In contrast, none of the choroidal thicknesses were significantly different among the investigated eyes in the strabismic amblyopia group. Conclusions We found no significant difference in inner retinal thickness in patients with unilateral amblyopia. Although there were significant differences in choroidal thickness with hyperopic anisometropic amblyopia, there was no significant difference for the strabismic amblyopia. The discrepancy in choroidal thickness between the two types of amblyopia may be due to both differences in ocular size and underlying mechanism.http://link.springer.com/article/10.1186/s12886-017-0559-3AmblyopiaRetinal thicknessChoroidal thicknessOptical coherence tomography |
| spellingShingle | Syunsuke Araki Atsushi Miki Katsutoshi Goto Tsutomu Yamashita Go Takizawa Kazuko Haruishi Yoshiaki Ieki Junichi Kiryu Kiyoshi Yaoeda Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomography BMC Ophthalmology Amblyopia Retinal thickness Choroidal thickness Optical coherence tomography |
| title | Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomography |
| title_full | Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomography |
| title_fullStr | Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomography |
| title_full_unstemmed | Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomography |
| title_short | Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomography |
| title_sort | macular retinal and choroidal thickness in unilateral amblyopia using swept source optical coherence tomography |
| topic | Amblyopia Retinal thickness Choroidal thickness Optical coherence tomography |
| url | http://link.springer.com/article/10.1186/s12886-017-0559-3 |
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