Targeting AXL induces tumor-intrinsic immunogenic response in tyrosine kinase inhibitor-resistant liver cancer

Targeting AXL induces tumor-intrinsic immunogenic response in tyrosine kinase inhibitor-resistant liver cancer

Abstract Hepatocellular carcinoma (HCC) is an aggressive malignancy without effective therapeutic approaches. Here, we evaluate the tumor-intrinsic mechanisms that attenuate the efficacy of immune checkpoint inhibitor (ICI) that is observed in patients with advanced HCC who progress on first-line ty...

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Bibliographic Details
Main Authors: Yunong Xie, Haofeng Wu, Yimiao He, Linglin Liu, Ianto Bosheng Huang, Lei Zhou, Cheuk-Yin Lin, Rainbow Wing-Hei Leung, Jia-Jian Loh, Terence Kin-Wah Lee, Jin Ding, Kwan Man, Stephanie Ma, Man Tong
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06493-0

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