Ciclesonide activates glucocorticoid signaling in neonatal rat lung but does not trigger adverse effects in the cortex and cerebellum

Ciclesonide activates glucocorticoid signaling in neonatal rat lung but does not trigger adverse effects in the cortex and cerebellum

Synthetic glucocorticoids (sGCs) such as dexamethasone (DEX), while used to mitigate inflammation and disease progression in premature infants with severe bronchopulmonary dysplasia (BPD), are also associated with significant adverse neurologic effects such as reductions in myelination and abnormali...

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Bibliographic Details
Main Authors: Juliann D. Jaumotte, Alexis L. Franks, Erin M. Bargerstock, Edwina Philip Kisanga, Heather L. Menden, Alexis Ghersi, Mahmoud Omar, Liping Wang, Anthony Rudine, Kelly L. Short, Neerupama Silswal, Timothy J. Cole, Venkatesh Sampath, A. Paula Monaghan-Nichols, Donald B. DeFranco
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Neurobiology of Disease
Subjects:
Ciclesonide
Dexamethasone
Bronchopulmonary dysplasia
Glucocorticoids
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121001716

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