Sodium nitroprusside protects HFD induced gut dysfunction via activating AMPKα/SIRT1 signaling

Sodium nitroprusside protects HFD induced gut dysfunction via activating AMPKα/SIRT1 signaling

Abstract Background Activation of Adenosine 5′-monophosphate-activated protein kinase/Sirtuin1 (AMPK/SIRT1) exerts an effect in alleviating obesity and gut damage. Sodium nitroprusside (SNP), a nitric oxide (NO) donor, has been reported to activate AMPK. This study was to investigate the effect of S...

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Bibliographic Details
Main Authors: Xiaomei Li, Chen Li, Yuanqi Li, Cong Liu, Xue Liang, Ting Liu, Zhihua Liu
Format: Article
Language:English
Published: BMC 2021-10-01
Series:BMC Gastroenterology
Subjects:
AMPKα/SIRT1 signaling
NO
SNP
Intestinal barrier dysfunction
HFD
Gut microbiota dysbiosis
Online Access:https://doi.org/10.1186/s12876-021-01934-y

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