Health-related quality of life of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis
Idiopathic pulmonary fibrosis (IPF) is one of the most common forms of interstitial lung disease presenting in persons 50 years and older. Through a comprehensive review of available studies, we aimed to assess health-related quality of life (HRQoL) of people living with IPF and the instruments used...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2020-11-01
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| Series: | European Respiratory Review |
| Online Access: | http://err.ersjournals.com/content/29/158/200154.full |
| _version_ | 1831557439605964800 |
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| author | Ingrid A. Cox Nicolas Borchers Arriagada Barbara de Graaff Tamera J. Corte Ian Glaspole Stella Lartey E. Haydn Walters Andrew J. Palmer |
| author_facet | Ingrid A. Cox Nicolas Borchers Arriagada Barbara de Graaff Tamera J. Corte Ian Glaspole Stella Lartey E. Haydn Walters Andrew J. Palmer |
| author_sort | Ingrid A. Cox |
| collection | DOAJ |
| description | Idiopathic pulmonary fibrosis (IPF) is one of the most common forms of interstitial lung disease presenting in persons 50 years and older. Through a comprehensive review of available studies, we aimed to assess health-related quality of life (HRQoL) of people living with IPF and the instruments used in this assessment. Searches were conducted up to May, 2020. Quality appraisal and data extraction were performed using pre-designed forms. Narrative synthesis approach was used to report results of the systematic review and a random effects model was used for the meta-analysis. A leave-one-out sensitivity analysis was performed, and a trim and fill method was used to assess publication bias. The review included 134 studies. The most used instruments to measure HRQoL were St George's Respiratory Questionnaire (SGRQ), Short Form 36 (SF36) and EuroQoL (EQ5D). Standardised mean scores (95% confidence interval) for these instruments were as follows: SGRQ total score: 44.72 (42.21–47.22); SF36 physical component score (PCS): 37.00 (34.74–39.26) SF36 mental component score (MCS): 50.18 (48.41–51.95); King's Brief Interstitial Lung Disease questionnaire total score: 58.38 (55.26–61.51); and EQ5D utility: 0.73 (0.68–0.79). Analysis of standardised means for both SGRQ and SF36 demonstrated worse scores in physical health domains as compared to mental health domains. This systematic review confirms that IPF negatively affected HRQoL, mostly impacting the physical health domains. This study also demonstrated that a diverse number of instruments are used to evaluate HRQoL. In view of this diversity, a standardised approach to measurement of HRQoL for IPF is important to ensure that comparisons made are reliable. |
| first_indexed | 2024-12-17T04:52:20Z |
| format | Article |
| id | doaj.art-d839cf856a154370a3c846fca0ef4eab |
| institution | Directory Open Access Journal |
| issn | 0905-9180 1600-0617 |
| language | English |
| last_indexed | 2024-12-17T04:52:20Z |
| publishDate | 2020-11-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | European Respiratory Review |
| spelling | doaj.art-d839cf856a154370a3c846fca0ef4eab2022-12-21T22:02:52ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172020-11-012915810.1183/16000617.0154-20200154-2020Health-related quality of life of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysisIngrid A. Cox0Nicolas Borchers Arriagada1Barbara de Graaff2Tamera J. Corte3Ian Glaspole4Stella Lartey5E. Haydn Walters6Andrew J. Palmer7 Menzies Institute for Medical Research, University of Tasmania, Tasmania, Australia Menzies Institute for Medical Research, University of Tasmania, Tasmania, Australia Menzies Institute for Medical Research, University of Tasmania, Tasmania, Australia Centre of Research Excellence for Pulmonary Fibrosis, Royal Prince Alfred Hospital, Camperdown, Australia Centre of Research Excellence for Pulmonary Fibrosis, Royal Prince Alfred Hospital, Camperdown, Australia Menzies Institute for Medical Research, University of Tasmania, Tasmania, Australia Menzies Institute for Medical Research, University of Tasmania, Tasmania, Australia Menzies Institute for Medical Research, University of Tasmania, Tasmania, Australia Idiopathic pulmonary fibrosis (IPF) is one of the most common forms of interstitial lung disease presenting in persons 50 years and older. Through a comprehensive review of available studies, we aimed to assess health-related quality of life (HRQoL) of people living with IPF and the instruments used in this assessment. Searches were conducted up to May, 2020. Quality appraisal and data extraction were performed using pre-designed forms. Narrative synthesis approach was used to report results of the systematic review and a random effects model was used for the meta-analysis. A leave-one-out sensitivity analysis was performed, and a trim and fill method was used to assess publication bias. The review included 134 studies. The most used instruments to measure HRQoL were St George's Respiratory Questionnaire (SGRQ), Short Form 36 (SF36) and EuroQoL (EQ5D). Standardised mean scores (95% confidence interval) for these instruments were as follows: SGRQ total score: 44.72 (42.21–47.22); SF36 physical component score (PCS): 37.00 (34.74–39.26) SF36 mental component score (MCS): 50.18 (48.41–51.95); King's Brief Interstitial Lung Disease questionnaire total score: 58.38 (55.26–61.51); and EQ5D utility: 0.73 (0.68–0.79). Analysis of standardised means for both SGRQ and SF36 demonstrated worse scores in physical health domains as compared to mental health domains. This systematic review confirms that IPF negatively affected HRQoL, mostly impacting the physical health domains. This study also demonstrated that a diverse number of instruments are used to evaluate HRQoL. In view of this diversity, a standardised approach to measurement of HRQoL for IPF is important to ensure that comparisons made are reliable.http://err.ersjournals.com/content/29/158/200154.full |
| spellingShingle | Ingrid A. Cox Nicolas Borchers Arriagada Barbara de Graaff Tamera J. Corte Ian Glaspole Stella Lartey E. Haydn Walters Andrew J. Palmer Health-related quality of life of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis European Respiratory Review |
| title | Health-related quality of life of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis |
| title_full | Health-related quality of life of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis |
| title_fullStr | Health-related quality of life of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis |
| title_full_unstemmed | Health-related quality of life of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis |
| title_short | Health-related quality of life of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis |
| title_sort | health related quality of life of patients with idiopathic pulmonary fibrosis a systematic review and meta analysis |
| url | http://err.ersjournals.com/content/29/158/200154.full |
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