Visualization of currents in neural models with similar behavior and different conductance densities
Conductance-based models of neural activity produce large amounts of data that can be hard to visualize and interpret. We introduce visualization methods to display the dynamics of the ionic currents and to display the models’ response to perturbations. To visualize the currents’ dynamics, we comput...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-01-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/42722 |
| _version_ | 1811199846544048128 |
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| author | Leandro M Alonso Eve Marder |
| author_facet | Leandro M Alonso Eve Marder |
| author_sort | Leandro M Alonso |
| collection | DOAJ |
| description | Conductance-based models of neural activity produce large amounts of data that can be hard to visualize and interpret. We introduce visualization methods to display the dynamics of the ionic currents and to display the models’ response to perturbations. To visualize the currents’ dynamics, we compute the percent contribution of each current and display them over time using stacked-area plots. The waveform of the membrane potential and the contribution of each current change as the models are perturbed. To represent these changes over a range of the perturbation control parameter, we compute and display the distributions of these waveforms. We illustrate these procedures in six examples of bursting model neurons with similar activity but that differ as much as threefold in their conductance densities. These visualization methods provide heuristic insight into why individual neurons or networks with similar behavior can respond widely differently to perturbations. |
| first_indexed | 2024-04-12T01:54:15Z |
| format | Article |
| id | doaj.art-d83ad9d7680e476e808049753e5c326b |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:54:15Z |
| publishDate | 2019-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-d83ad9d7680e476e808049753e5c326b2022-12-22T03:52:51ZengeLife Sciences Publications LtdeLife2050-084X2019-01-01810.7554/eLife.42722Visualization of currents in neural models with similar behavior and different conductance densitiesLeandro M Alonso0https://orcid.org/0000-0001-8211-2855Eve Marder1https://orcid.org/0000-0001-9632-5448Volen Center and Biology Department, Brandeis University, Waltham, United StatesVolen Center and Biology Department, Brandeis University, Waltham, United StatesConductance-based models of neural activity produce large amounts of data that can be hard to visualize and interpret. We introduce visualization methods to display the dynamics of the ionic currents and to display the models’ response to perturbations. To visualize the currents’ dynamics, we compute the percent contribution of each current and display them over time using stacked-area plots. The waveform of the membrane potential and the contribution of each current change as the models are perturbed. To represent these changes over a range of the perturbation control parameter, we compute and display the distributions of these waveforms. We illustrate these procedures in six examples of bursting model neurons with similar activity but that differ as much as threefold in their conductance densities. These visualization methods provide heuristic insight into why individual neurons or networks with similar behavior can respond widely differently to perturbations.https://elifesciences.org/articles/42722neuronal oscillatorsNa+ channelsCa++ channelsK+ channelsconductance-basedionic channels |
| spellingShingle | Leandro M Alonso Eve Marder Visualization of currents in neural models with similar behavior and different conductance densities eLife neuronal oscillators Na+ channels Ca++ channels K+ channels conductance-based ionic channels |
| title | Visualization of currents in neural models with similar behavior and different conductance densities |
| title_full | Visualization of currents in neural models with similar behavior and different conductance densities |
| title_fullStr | Visualization of currents in neural models with similar behavior and different conductance densities |
| title_full_unstemmed | Visualization of currents in neural models with similar behavior and different conductance densities |
| title_short | Visualization of currents in neural models with similar behavior and different conductance densities |
| title_sort | visualization of currents in neural models with similar behavior and different conductance densities |
| topic | neuronal oscillators Na+ channels Ca++ channels K+ channels conductance-based ionic channels |
| url | https://elifesciences.org/articles/42722 |
| work_keys_str_mv | AT leandromalonso visualizationofcurrentsinneuralmodelswithsimilarbehavioranddifferentconductancedensities AT evemarder visualizationofcurrentsinneuralmodelswithsimilarbehavioranddifferentconductancedensities |