Current progress and challenges in the development of brain tissue models: How to grow up the changeable brain in vitro?
In vitro modeling of brain tissue is a promising but not yet resolved problem in modern neurobiology and neuropharmacology. Complexity of the brain structure and diversity of cell-to-cell communication in (patho)physiological conditions make this task almost unachievable. However, establishment of n...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2024-03-01
|
| Series: | Journal of Tissue Engineering |
| Online Access: | https://doi.org/10.1177/20417314241235527 |
| _version_ | 1797253803933696000 |
|---|---|
| author | Alla B Salmina Olga P Alexandrova Anton S Averchuk Sofia A Korsakova Mikis R Saridis Sergey N Illarioshkin Stanislav O Yurchenko |
| author_facet | Alla B Salmina Olga P Alexandrova Anton S Averchuk Sofia A Korsakova Mikis R Saridis Sergey N Illarioshkin Stanislav O Yurchenko |
| author_sort | Alla B Salmina |
| collection | DOAJ |
| description | In vitro modeling of brain tissue is a promising but not yet resolved problem in modern neurobiology and neuropharmacology. Complexity of the brain structure and diversity of cell-to-cell communication in (patho)physiological conditions make this task almost unachievable. However, establishment of novel in vitro brain models would ultimately lead to better understanding of development-associated or experience-driven brain plasticity, designing efficient approaches to restore aberrant brain functioning. The main goal of this review is to summarize the available data on methodological approaches that are currently in use, and to identify the most prospective trends in development of neurovascular unit, blood-brain barrier, blood-cerebrospinal fluid barrier, and neurogenic niche in vitro models. The manuscript focuses on the regulation of adult neurogenesis, cerebral microcirculation and fluids dynamics that should be reproduced in the in vitro 4D models to mimic brain development and its alterations in brain pathology. We discuss approaches that are critical for studying brain plasticity, deciphering the individual person-specific trajectory of brain development and aging, and testing new drug candidates in the in vitro models. |
| first_indexed | 2024-04-24T21:39:52Z |
| format | Article |
| id | doaj.art-d83c27e9a98b4619a5bb079cf0df182f |
| institution | Directory Open Access Journal |
| issn | 2041-7314 |
| language | English |
| last_indexed | 2024-04-24T21:39:52Z |
| publishDate | 2024-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj.art-d83c27e9a98b4619a5bb079cf0df182f2024-03-21T09:04:01ZengSAGE PublishingJournal of Tissue Engineering2041-73142024-03-011510.1177/20417314241235527Current progress and challenges in the development of brain tissue models: How to grow up the changeable brain in vitro?Alla B Salmina0Olga P Alexandrova1Anton S Averchuk2Sofia A Korsakova3Mikis R Saridis4Sergey N Illarioshkin5Stanislav O Yurchenko6Bauman Moscow State Technical University, Moscow, RussiaBauman Moscow State Technical University, Moscow, RussiaBauman Moscow State Technical University, Moscow, RussiaBauman Moscow State Technical University, Moscow, RussiaBauman Moscow State Technical University, Moscow, RussiaBrain Science Institute, Research Center of Neurology, Moscow, RussiaBauman Moscow State Technical University, Moscow, RussiaIn vitro modeling of brain tissue is a promising but not yet resolved problem in modern neurobiology and neuropharmacology. Complexity of the brain structure and diversity of cell-to-cell communication in (patho)physiological conditions make this task almost unachievable. However, establishment of novel in vitro brain models would ultimately lead to better understanding of development-associated or experience-driven brain plasticity, designing efficient approaches to restore aberrant brain functioning. The main goal of this review is to summarize the available data on methodological approaches that are currently in use, and to identify the most prospective trends in development of neurovascular unit, blood-brain barrier, blood-cerebrospinal fluid barrier, and neurogenic niche in vitro models. The manuscript focuses on the regulation of adult neurogenesis, cerebral microcirculation and fluids dynamics that should be reproduced in the in vitro 4D models to mimic brain development and its alterations in brain pathology. We discuss approaches that are critical for studying brain plasticity, deciphering the individual person-specific trajectory of brain development and aging, and testing new drug candidates in the in vitro models.https://doi.org/10.1177/20417314241235527 |
| spellingShingle | Alla B Salmina Olga P Alexandrova Anton S Averchuk Sofia A Korsakova Mikis R Saridis Sergey N Illarioshkin Stanislav O Yurchenko Current progress and challenges in the development of brain tissue models: How to grow up the changeable brain in vitro? Journal of Tissue Engineering |
| title | Current progress and challenges in the development of brain tissue models: How to grow up the changeable brain in vitro? |
| title_full | Current progress and challenges in the development of brain tissue models: How to grow up the changeable brain in vitro? |
| title_fullStr | Current progress and challenges in the development of brain tissue models: How to grow up the changeable brain in vitro? |
| title_full_unstemmed | Current progress and challenges in the development of brain tissue models: How to grow up the changeable brain in vitro? |
| title_short | Current progress and challenges in the development of brain tissue models: How to grow up the changeable brain in vitro? |
| title_sort | current progress and challenges in the development of brain tissue models how to grow up the changeable brain in vitro |
| url | https://doi.org/10.1177/20417314241235527 |
| work_keys_str_mv | AT allabsalmina currentprogressandchallengesinthedevelopmentofbraintissuemodelshowtogrowupthechangeablebraininvitro AT olgapalexandrova currentprogressandchallengesinthedevelopmentofbraintissuemodelshowtogrowupthechangeablebraininvitro AT antonsaverchuk currentprogressandchallengesinthedevelopmentofbraintissuemodelshowtogrowupthechangeablebraininvitro AT sofiaakorsakova currentprogressandchallengesinthedevelopmentofbraintissuemodelshowtogrowupthechangeablebraininvitro AT mikisrsaridis currentprogressandchallengesinthedevelopmentofbraintissuemodelshowtogrowupthechangeablebraininvitro AT sergeynillarioshkin currentprogressandchallengesinthedevelopmentofbraintissuemodelshowtogrowupthechangeablebraininvitro AT stanislavoyurchenko currentprogressandchallengesinthedevelopmentofbraintissuemodelshowtogrowupthechangeablebraininvitro |