The short-lived African turquoise killifish: an emerging experimental model for ageing
Human ageing is a fundamental biological process that leads to functional decay, increased risk for various diseases and, ultimately, death. Some of the basic biological mechanisms underlying human ageing are shared with other organisms; thus, animal models have been invaluable in providing key mech...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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The Company of Biologists
2016-02-01
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| Series: | Disease Models & Mechanisms |
| Subjects: | |
| Online Access: | http://dmm.biologists.org/content/9/2/115 |
| _version_ | 1811324213444739072 |
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| author | Yumi Kim Hong Gil Nam Dario Riccardo Valenzano |
| author_facet | Yumi Kim Hong Gil Nam Dario Riccardo Valenzano |
| author_sort | Yumi Kim |
| collection | DOAJ |
| description | Human ageing is a fundamental biological process that leads to functional decay, increased risk for various diseases and, ultimately, death. Some of the basic biological mechanisms underlying human ageing are shared with other organisms; thus, animal models have been invaluable in providing key mechanistic and molecular insights into the common bases of biological ageing. In this Review, we briefly summarise the major applications of the most commonly used model organisms adopted in ageing research and highlight their relevance in understanding human ageing. We compare the strengths and limitations of different model organisms and discuss in detail an emerging ageing model, the short-lived African turquoise killifish. We review the recent progress made in using the turquoise killifish to study the biology of ageing and discuss potential future applications of this promising animal model. |
| first_indexed | 2024-04-13T14:10:18Z |
| format | Article |
| id | doaj.art-d83dccc9601e458cbe5ef56cfe0d8a34 |
| institution | Directory Open Access Journal |
| issn | 1754-8411 1754-8403 |
| language | English |
| last_indexed | 2024-04-13T14:10:18Z |
| publishDate | 2016-02-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Disease Models & Mechanisms |
| spelling | doaj.art-d83dccc9601e458cbe5ef56cfe0d8a342022-12-22T02:43:49ZengThe Company of BiologistsDisease Models & Mechanisms1754-84111754-84032016-02-019211512910.1242/dmm.023226023226The short-lived African turquoise killifish: an emerging experimental model for ageingYumi Kim0Hong Gil Nam1Dario Riccardo Valenzano2 Max Planck Institute for Biology of Ageing, D50931, Cologne, Germany Department of New Biology, DGIST, 711-873, Daegu, Republic of Korea Max Planck Institute for Biology of Ageing, D50931, Cologne, Germany Human ageing is a fundamental biological process that leads to functional decay, increased risk for various diseases and, ultimately, death. Some of the basic biological mechanisms underlying human ageing are shared with other organisms; thus, animal models have been invaluable in providing key mechanistic and molecular insights into the common bases of biological ageing. In this Review, we briefly summarise the major applications of the most commonly used model organisms adopted in ageing research and highlight their relevance in understanding human ageing. We compare the strengths and limitations of different model organisms and discuss in detail an emerging ageing model, the short-lived African turquoise killifish. We review the recent progress made in using the turquoise killifish to study the biology of ageing and discuss potential future applications of this promising animal model.http://dmm.biologists.org/content/9/2/115AgeingLongevityAge-associated diseasesModel organismsTurquoise killifishNothobranchius furzeri |
| spellingShingle | Yumi Kim Hong Gil Nam Dario Riccardo Valenzano The short-lived African turquoise killifish: an emerging experimental model for ageing Disease Models & Mechanisms Ageing Longevity Age-associated diseases Model organisms Turquoise killifish Nothobranchius furzeri |
| title | The short-lived African turquoise killifish: an emerging experimental model for ageing |
| title_full | The short-lived African turquoise killifish: an emerging experimental model for ageing |
| title_fullStr | The short-lived African turquoise killifish: an emerging experimental model for ageing |
| title_full_unstemmed | The short-lived African turquoise killifish: an emerging experimental model for ageing |
| title_short | The short-lived African turquoise killifish: an emerging experimental model for ageing |
| title_sort | short lived african turquoise killifish an emerging experimental model for ageing |
| topic | Ageing Longevity Age-associated diseases Model organisms Turquoise killifish Nothobranchius furzeri |
| url | http://dmm.biologists.org/content/9/2/115 |
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